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Aging and the Immune System: the Impact of Immunosenescence on Viral Infection, Immunity and Vaccine Immunogenicity

Oh SJ, Lee JK, Shin OS

Immunosenescence is characterized by a progressive deterioration of the immune system associated with aging. Multiple components of both innate and adaptive immune systems experience aging-related changes, such as alterations in...
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COPD as a Disease of Immunosenescence

Cho WK, Lee CG, Kim LK

Although chronic obstructive pulmonary disease (COPD) is regarded as a chronic inflammatory lung disease, the disease mechanism is still not known. Intriguingly, aging lungs are quite similar to COPD-affected lungs...
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Microbiota: A Key for Healthy Aging

Choi YJ, Lee DH

A growing body of literature has suggested that changes in the composition of gut microbiota could be associated with age-related processes. Significant changes in the gastrointestinal microbiota in the elderly...
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The role of senescence of bone marrow cells in acute kidney injury

Lee J, Ko YS, Lee HY, Yang J, Oh S, Jo SK, Cho W, Kim MG

BACKGROUND: The prevalence of acute kidney injury (AKI) in elderly patients has grown considerably. Age-associated changes in the immune system can be one of the critical factors determining AKI outcomes....
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Immune enhancing effects of Weissella cibaria JW15 in C57BL/6J mice aged 28 months

Park HE, Ahn HS, Lee WK

Aging is a growing concern of age-associated aberrations in immune system or immunosenescence. Probiotics contain not only these general health advantages but also other the regulation of host immune function....
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Cardiovascular and Metabolic Diseases Etiology Research Center (CMERC) cohort: study protocol and results of the first 3 years of enrollment

Shim JS, Song BM, Lee JH, Lee SW, Park JH, Choi DP, Lee MH, Ha KH, Kim DJ, Park S, Lee WW, Kim HC

Although the etiologies of cardiovascular disease (CVD) are widely understood, the goal of finding a globally effective solution for preventing CVD is unrealistic. Therefore, we aimed to conduct a community-based...
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