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Autoantibody-Mediated Dysfunction of Salivary Glands Leads to Xerostomia in SKG Mice

Choi SS, Jang E, Jang K, Jung SJ, Hwang KG, Youn J

Sjögren's syndrome (SS) is a chronic heterogeneous disease that mainly affects exocrine glands, leading to sicca syndromes such as xerostomia. Despite the second highest prevalence rate among systemic autoimmune diseases,...
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Evaluating Antitumor Activity of Kiatomab by Targeting Cancer Stem Cell-Specific KIAA1114 Antigen in Mice

Kim SW, Park HW, Kim H, Lee S, Choi SY, Park Y, Lee SW

A full-length translational product of the trophinin gene, KIAA1114, is a distinctive marker of cancer stem cells in human hepatocellular carcinoma, and a mAb, Kiatomab, is specific to KIAA1114 antigen....
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Prenatal Exposure to Lead and Chromium is Associated with IL-13 Levels in Umbilical Cord Blood and Severity of Atopic Dermatitis: COCOA Study

Kim J, Kim S, Woo SY, Chung JY, Hong YS, Oh SY, Choi SJ, Oh SY, Kim KW, Shin YH, Won HS, Lee KJ, Kim SH, Kwon JY, Lee SH, Hong SJ, Ahn K

There have been few studies investigating the association between atopic dermatitis (AD) and prenatal exposure to heavy metals. We aimed to evaluate whether prenatal exposure to heavy metals is associated...
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A Critical Role of PCSK9 in Mediating IL-17-Producing T Cell Responses in Hyperlipidemia

Kim YU, Kee P, Danila D, Teng BB

We previously demonstrated that atherogenic Ldlr(−/−)Apobec1(−/−) (LDb) double knockout mice lacking both low-density lipoprotein receptor (LDLR) and apolipoprotein B mRNA-editing catalytic polypeptide-1 (Apobec1) had increased serum IL-17 levels, with T...
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Zika Virus Impairs Host NLRP3-mediated Inflammasome Activation in an NS3-dependent Manner

Gim E, Shim DW, Hwang I, Shin OS, Yu JW

Zika virus (ZIKV) is a mosquito-borne flavivirus associated with severe neurological disorders including Guillain-Barré syndrome and microcephaly. The host innate immune responses against ZIKV infection are essential for protection; however,...
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Lactobacillus pentosus Modulates Immune Response by Inducing IL-10 Producing Tr1 Cells

Kim JE, Sharma A, Sharma G, Lee SY, Shin HS, Rudra D, Im SH

Several gut commensals have been shown to modulate host immune response. Recently, many food derived microbes have also been reported to affect the immune system. However, a mechanism to identify...
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Human Immunity Against Campylobacter Infection

Hameed A

Campylobacter is a worldwide foodborne pathogen, associated with human gastroenteritis. The efficient translocation of Campylobacter and its ability to secrete toxins into host cells are the 2 key features of...
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Aging and the Immune System: the Impact of Immunosenescence on Viral Infection, Immunity and Vaccine Immunogenicity

Oh SJ, Lee JK, Shin OS

Immunosenescence is characterized by a progressive deterioration of the immune system associated with aging. Multiple components of both innate and adaptive immune systems experience aging-related changes, such as alterations in...
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