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Cordyceps militaris Enhances MHC-restricted Antigen Presentation via the Induced Expression of MHC Molecules and Production of Cytokines

Shin S, Park Y, Kim S, Oh HE, Ko YW, Han S, Lee S, Lee CK, Cho K, Kim K

BACKGROUND: Cordyceps militarys water extract (CME) has been reported to exert antitumor and immunomodulatory activities in vivo and in vitro. However, the therapeutic mechanism has not yet been elucidated. In...
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Expression of Hepatitis B Virus X Protein in Hepatocytes Suppresses CD8+ T Cell Activity

Lee MJ, Jin YH, Kim K, Choi Y, Kim HC, Park S

BACKGROUND: CD8+ T cells contribute to the clearance of Hepatitis B virus (HBV) infection and an insufficient CD8+ T cell response may be one of the major factors leading to...
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T-Cell Dysfunction and Inhibitory Receptors in Hepatitis C Virus Infection

Lee J, Suh WI, Shin EC

Dysfunction of the virus-specific T cells is a cardinal feature in chronic persistent viral infections such as one caused by hepatitis C virus (HCV). In chronic HCV infection, virus-specific dysfunctional...
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Heterogeneity of IL-22-producing Lymphoid Tissue Inducer-like Cells in Human and Mouse

Kim S, Han S, Kim MY

Lymphoid tissue inducer (LTi) cells have been characterized in mouse as a key cell when secondary lymphoid tissues are organized during development and memory T cells are formed after birth....
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Role of Th17 Cell and Autoimmunity in Chronic Obstructive Pulmonary Disease

Hong SC, Lee SH

The molecular mechanisms involved in the pathogenesis of chronic obstructive pulmonary disease (COPD) are poorly defined. Accumulating evidences indicate that chronic inflammatory responses and adaptive immunity play important roles in...
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