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Characterization of a Novel Gene in the Extended MHC Region of Mouse, NG29/Cd320, a Homolog of the Human CD320

Park HJ, Kim JY, Jung KI, Kim TJ

BACKGROUND: The MHC region of the chromosome contains a lot of genes involved in immune responses. Here we have investigated the mouse NG29/Cd320 gene in the centrometrically extended MHC region...
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Further Characterization of Activin A-induced IgA Response in Murine B Lymphocytes

Lee HJ, Kim PH

We have recently shown that activin A, a member of TGF-beta superfamily, stimulates mouse B cells to express IgA isotype but other isotypes. In the present study, we further characterized...
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Expression and Function of TLR2 on CD4 Versus CD8 T Cells

Lee SM, Joo YD, Seo SK

BACKGROUND: Toll-like receptors (TLRs) play a fundamental role in innate immunity through their capacity to recognize pathogen-associated molecular patterns. Also, TLRs that are expressed in T cells are reported to...
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Regulation of Tumor Immune Surveillance and Tumor Immune Subversion by TGF-beta

Park HY, Wakefield , Mamura M

Transforming growth factor-beta (TGF-beta) is a highly pleiotropic cytokine playing pivotal roles in immune regulation. TGF-beta facilitates tumor cell survival and metastasis by targeting multiple cellular components. Focusing on its...
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Post-transcriptional Regulation of NK Cell Activation

Kim TD, Park JY, Choi I

Natural killer (NK) cells play key roles in innate and adaptive immune defenses. NK cell responses are mediated by two major mechanisms: the direct cytolysis of target cells, and immune...
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