- Mapping of Human Cytomegalovirus IE1 Responsive Elements in the c-jun Promoter
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Kim DJ, Kim JH, Choi SB, Han TH, Park CG, Hwang ES, Cha CY
- KMID: 1551995
- J Korean Soc Virol.
- 1998 Sep;28(3):267-274.
Human cytomegalovirus (HCMV) has the ability to activate the espremission of many viral and cellular genes. Among various viral proteins, the immediate early proteins (IE1-72kDa, IE2-86kDa) have been known to... -
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- B-cell translocation gene 2 positively regulates GLP-1-stimulated insulin secretion via induction of PDX-1 in pancreatic beta-cells
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Hwang SL, Kwon O, Kim SG, Lee IK, Kim YD
- KMID: 2154244
- Exp Mol Med.
- 2013 May;45(5):e25.
Glucagon-like peptide-1 (GLP-1) is a potent glucoincretin hormone and an important agent for the treatment of type 2 diabetes. Here we demonstrate that B-cell translocation gene 2 (BTG2) is a... -
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- Implication of Egr-1 in trifluoperazine-induced growth inhibition in human U87MG glioma cells
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Shin SY, Kim CG, Hong DD, Kim JH, Lee YH
- KMID: 1094083
- Exp Mol Med.
- 2004 Aug;36(4):380-386.
The early growth response gene-1 (Egr-1) is a tumor suppressor which plays an important role in cell growth, differentiation and apoptosis. Egr-1 has been shown to be down-regulated in many... -
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- Inhibitory effect of Hsp70 on angiotensin II-induced vascular smooth muscle cell hypertrophy
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Zheng Y, Im CN, Seo JS
- KMID: 1098085
- Exp Mol Med.
- 2006 Oct;38(5):509-518.
Angiotensin II (Ang II), which is an important mediator of both vascular responsiveness and growth, has been shown to induce vascular smooth muscle cell (VSMC) hypertrophy via the activation of... -
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- The Role of Hepatitis C Virus Core Protein on Liver Fibrogenesis: A Study Using an In Vitro Co-culture System
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Shin JY, Yoon SK, Wang JS, Hur W, Ryu JS, Bae SH, Choi JY, Yang JM, Yang SH, Sung YC, Chung KW, Sun HS
- KMID: 1112191
- Korean J Gastroenterol.
- 2003 Nov;42(5):400-408.
BACKGROUND/AIMS: The study of liver fibrogenesis by hepatitis C virus (HCV) has been limited due to the lack of an efficiency in vitro culture systems. In the present study,... -
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- HCV core protein promotes liver fibrogenesis via up-regulation of CTGF with TGF-beta1
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Shin JY, Hur W, Wang JS, Jang JW, Kim CW, Bae SH, Jang SK, Yang SH, Sung YC, Kwon OJ, Yoon SK
- KMID: 755753
- Exp Mol Med.
- 2005 Apr;37(2):138-145.
Liver cirrhosis is one of the major complications of hepatitis C virus (HCV) infection, but the mechanisms underlying HCV-related fibrogenesis are still not clear. Although the roles of HCV core... -
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- Human Cytomegalovirus IE1 Protein Enhances Herpes Simplex Virus Type 1-induced Syncytial Formation in U373MG Cells
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Shin KC, Park CG, Hwang ES, Cha CY
- KMID: 1107532
- J Korean Med Sci.
- 2008 Dec;23(6):1046-1052.
- doi: 10.3346/jkms.2008.23.6.1046
Co-infection of herpes simplex virus type 1 (HSV-1) and human cytomegalovirus (HCMV) is not uncommon in immunocompromised hosts. Importantly, organ transplant recipients concurrently infected with HSV-1 and HCMV have a... -
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- Aldosterone Upregulates Connective Tissue Growth Factor Gene Expression via p38 MAPK Pathway and Mineralocorticoid Receptor in Ventricular Myocytes
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Lee YS, Kim JA, Kim KL, Jang HS, Kim JM, Lee JY, Shin IS, Lee JS, Suh W, Choi JH, Jeon ES, Byun J, Kim DK
- KMID: 1778560
- J Korean Med Sci.
- 2004 Dec;19(6):805-811.
- doi: 10.3346/jkms.2004.19.6.805
The effect of aldosterone on connective tissue growth factor (CTGF) was examined in rat embryonic ventricular myocytes. Upon aldosterone treatment, CTGF expression was significantly increased in a dose and time-dependent... -
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- Monocrotaline-induced pulmonary hypertension correlates with upregulation of connective tissue growth factor expression in the lung
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Lee YS, Byun J, Kim JA, Lee JS, Kim KL, Suh YL, Kim JM, Jang HS, Lee JY, Shin IS, Suh W, Jeon ES, Kim DK
- KMID: 1033098
- Exp Mol Med.
- 2005 Feb;37(1):27-35.
Pulmonary hypertension (PH) is characterized by structural and functional changes in the lung including proliferation of vascular smooth muscle cells (VSMCs) and excessive collagen synthesis. Although connective tissue growth factor... -
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