- Molecular and Cellular Substrates of Neuroinflammation in Alzheimer Disease and Depression
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Im HI
- KMID: 2467311
- Int Neurourol J.
- 2019 Nov;23(Suppl 2):S51-S52.
- doi: 10.5213/inj.1920edi.008
No abstract available. -
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- Epigenetic Dysfunction of Neurodegenerative Diseases, MeCP2 and More
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Im HI
- KMID: 2536156
- Int Neurourol J.
- 2022 Nov;26(Suppl 2):S83-84.
- doi: 10.5213/inj.2222edi04
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- Drug Abuse and Psychosis: New Insights into Drug-induced Psychosis
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Ham S, Kim TK, Chung S, Im HI
- KMID: 2368651
- Exp Neurobiol.
- 2017 Feb;26(1):11-24.
- doi: 10.5607/en.2017.26.1.11
Addictive drug use or prescribed medicine abuse can cause psychosis. Some representative symptoms frequently elicited by patients with psychosis are hallucination, anhedonia, and disrupted executive functions. These psychoses are categorized... -
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- Pathophysiological Role of Neuroinflammation in Neurodegenerative Diseases and Psychiatric Disorders
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Hong H, Kim BS, Im HI
- KMID: 2309833
- Int Neurourol J.
- 2016 May;20(Suppl 1):S2-S7.
Brain diseases and disorders such as Alzheimer disease, Parkinson disease, depression, schizophrenia, autism, and addiction lead to reduced quality of daily life through abnormal thoughts, perceptions, emotional states, and behavior.... -
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- Ceramide is Involved in MPP+ -induced Cytotoxicity in Human Neuroblastoma Cells
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Nam EJ, Lee HS, Lee YJ, Joo WS, Maeng S, Im HI, Park CW, Kim YS
- KMID: 1615193
- Korean J Physiol Pharmacol.
- 2002 Dec;6(6):281-286.
To understand the cytotoxic mechanism of MPP+, we examined the involvement of ceramide in MPP+ -induced cytotoxicity to human neuroblastoma SH-SY5Y cells. When SH-SY5Y cells were exposed to MPP+, MPP+... -
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- Claustral MeCP2 Regulates Methamphetamine-induced Conditioned Place Preference in Cynomolgus Monkey
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Bae J, Ahn S, Cho DW, Kim HS, Han SC, Im HI
- KMID: 2537958
- Exp Neurobiol.
- 2022 Dec;31(6):390-400.
- doi: 10.5607/en22034
The claustrum, a brain nucleus located between the cortex and the striatum, has recently been highlighted in drug-related reward processing. Methyl CpG-binding protein-2 (MeCP2) is a transcriptional regulator that represses... -
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- Methyl-CpG Binding Protein 2 in Alzheimer Dementia
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Kim B, Choi Y, Kim HS, Im HI
- KMID: 2467315
- Int Neurourol J.
- 2019 Nov;23(Suppl 2):S72-S81.
- doi: 10.5213/inj.1938196.098
Despite decades of research on Alzheimer disease, understanding the complexity of the genetic and molecular interactions involved in its pathogenesis remains far from our grasp. Methyl-CpG Binding Protein 2 (MeCP2)... -
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- Baicalein Protects 6-OHDA-induced Neuronal Damage by Suppressing Oxidative Stress
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Im HI, Nam E, Lee ES, Hwang YJ, Kim YS
- KMID: 1587469
- Korean J Physiol Pharmacol.
- 2006 Dec;10(6):309-315.
The protective effects of baicalein, one of the flavonoids in Scutellaria baicalensis Georgi, were evaluated against 6-hydroxydopamine (6-OHDA)-induced neuronal damage in mice and cultured human neuroblastoma cells. Nigrostriatal damage was... -
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- Effects of Fetal Mesencephalic Cell Grafts on the Intrastriatal 6-hydroxydoapmine Lesioned Rats
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Joo WS, Nam E, Im HI, Jung JA, Lee ES, Hwang YJ, Kim YS
- KMID: 1611426
- Korean J Physiol Pharmacol.
- 2004 Oct;8(5):245-251.
The effects of fetal mesencephalic cell grafts on the restoration of nigrostriatal dopaminergic function were studied in the intrastriatal 6-hydroxydopamine-lesioned rats. Four weeks after lesioning, transplantation of ventral mesencephalic cells... -
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- Striatal ZBTB16 Is Associated With Cognitive Deficits in Alzheimer Disease Mice
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Lee S, Kim TK, Choi JE, Kim HS, Im HI
- KMID: 2536159
- Int Neurourol J.
- 2022 Nov;26(Suppl 2):S106-116.
- doi: 10.5213/inj.2244254.127
Purpose: In Alzheimer disease (AD), brain regions such as the cortex and the hippocampus show abundant amyloid load which correlates with cognitive function decline. Prior to the significant development of... -
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- Comprehensive MicroRNAome Analysis of the Relationship Between Alzheimer Disease and Cancer in PSEN Double-Knockout Mice
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Ham S, Kim TK, Ryu J, Kim YS, Tang YP, Im HI
- KMID: 2431864
- Int Neurourol J.
- 2018 Dec;22(4):237-245.
- doi: 10.5213/inj.1836274.137
PURPOSE: Presenilins are functionally important components of γ-secretase, which cleaves a number of transmembrane proteins. Manipulations of PSEN1 and PSEN2 have been separately studied in Alzheimer disease (AD) and cancer... -
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- Involvement of Oxidative Stress and Poly (ADP-ribose) Polymerase Activation in 3-Nitropropionic Acid-induced Cytotoxicity in Human Neuroblastoma Cells
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Nam E, Lee YJ, Oh YA, Jung JA, Im HI, Koh SE, Maeng S, Joo WS, Kim YS
- KMID: 1607517
- Korean J Physiol Pharmacol.
- 2003 Dec;7(6):325-331.
3-Nitropropionic acid (3-NP) inhibits electron transport in mitochondria, leading to a metabolic failure. In order to elucidate the mechanism underlying this toxicity, we examined a few biochemical changes possibly involved... -
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- Quantitative Sequencing Analysis of the Striatal Transcriptome in a Mouse Model of Alzheimer Disease
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Kim TK, Lee S, Im HI
- KMID: 2536160
- Int Neurourol J.
- 2022 Nov;26(Suppl 2):S117-125.
- doi: 10.5213/inj.2244256.128
Purpose: The purpose of this study was to analyze the transcriptomic changes in the striatum of amyloid precursor protein/presenilin 1 (APP/PS1) transgenic mice and uncover its association with the methyl-CpG... -
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