- Metformin Suppresses MHC-Restricted Antigen Presentation by Inhibiting Co-Stimulatory Factors and MHC Molecules in APCs
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Shin S, Hyun B, Lee A, Kong H, Han S, Lee CK, Ha NJ, Kim K
- KMID: 2170683
- Biomol Ther.
- 2013 Jan;21(1):35-41.
Metformin is widely used for T2D therapy but its cellular mechanism of action is undefined. Recent studies on the mechanism of metformin in T2D have demonstrated involvement of the immune... -
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- Immunomodulatory Effects of Dioscoreae Rhizome Against Inflammation through Suppressed Production of Cytokines Via Inhibition of the NF-kappaB Pathway
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Kim S, Shin S, Hyun B, Kong H, Han S, Lee A, Lee S, Kim K
- KMID: 2150747
- Immune Netw.
- 2012 Oct;12(5):181-188.
- doi: 10.4110/in.2012.12.5.181
Dioscoreae Rhizome (DR) has been used in traditional medicine to treat numerous diseases and is reported to have anti-diabetes and anti-tumor activities. To identify a bioactive traditional medicine with anti-inflammatory... -
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- Metformin Down-regulates TNF-alpha Secretion via Suppression of Scavenger Receptors in Macrophages
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Hyun B, Shin S, Lee A, Lee S, Song Y, Ha NJ, Cho KH, Kim K
- KMID: 2150777
- Immune Netw.
- 2013 Aug;13(4):123-132.
- doi: 10.4110/in.2013.13.4.123
Obesity is consistently increasing in prevalence and can trigger insulin resistance and type 2 diabetes. Many lines of evidence have shown that macrophages play a major role in inflammation associated... -
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