- BRCA1/2 mutation status in patients with metachronous breast and ovarian malignancies: clues towards the implementation of genetic counseling
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Chao A, Lin YH, Yang LY, Wu RC, Chang WY, Chang PY, Chang SC, Lin CY, Huang HJ, Lin CT, Chou HH, Huang KG, Kuo WL, Chang TC, Lai CH
- KMID: 2500476
- J Gynecol Oncol.
- 2020 Apr;31(3):e24.
- doi: 10.3802/jgo.2020.31.e24
Objective: The characteristics of patients with metachronous breast and ovarian malignancies and the pathogenic role of BRCA1/2 mutations remain poorly understood. We investigated these issues through a review of hospital... -
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- Virtual Screening and Testing of GSK-3 Inhibitors Using Human SH-SY5Y Cells Expressing Tau Folding Reporter and Mouse Hippocampal Primary Culture under Tau Cytotoxicity
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Lin CH, Hsieh YS, Sun YC, Huang WH, Chen SL, Weng ZK, Lin TH, Wu YR, Chang KH, Huang HJ, Lee GC, Hsieh-Li HM, Lee-Chen GJ
- KMID: 2537589
- Biomol Ther.
- 2023 Jan;31(1):127-138.
- doi: 10.4062/biomolther.2022.035
Glycogen synthase kinase-3β (GSK-3β) is an important serine/threonine kinase that implicates in multiple cellular processes and links with the neurodegenerative diseases including Alzheimer’s disease (AD). In this study, structure-based virtual... -
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- Maintenance of pegylated liposomal doxorubicin/carboplatin in patients with advanced ovarian cancer: randomized study of an Asian Gynecologic Oncology Group
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Lai CH, Vallikad E, Lin H, Yang LY, Jung SM, Liu HE, Ou YC, Chou HH, Lin CT, Huang HJ, Huang KG, Qiu J, Hung YC, Wu TI, Chang WY, Tan KT, Lin CY, Chao A, Chang CJ
- KMID: 2500404
- J Gynecol Oncol.
- 2020 Jan;31(1):e5.
- doi: 10.3802/jgo.2020.31.e5
Objectives: An Asian Gynecologic Oncology Group phase III randomized trial was conducted to determine whether maintenance chemotherapy could improve progression-free survival (PFS) in stages III/IV ovarian cancer. Methods: Between 2007 and... -
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- A longitudinal analysis with CA-125 to predict overall survival in patients with ovarian cancer
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Chiang AJ, Chen J, Chung YC, Huang HJ, Liou WS, Chang C
- KMID: 1811188
- J Gynecol Oncol.
- 2014 Jan;25(1):51-57.
- doi: 10.3802/jgo.2014.25.1.51
OBJECTIVE: The objective of this study was to explore the association of longitudinal CA-125 measurements with overall survival (OS) time by developing a flexible model for patient-specific CA-125 profiles, and... -
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