- Psammaplin A is a natural prodrug that inhibits class I histone deacetylase
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Kim DH, Shin J, Kwon HJ
- KMID: 1103680
- Exp Mol Med.
- 2007 Feb;39(1):47-55.
Histone deacetylase (HDAC) has been highlighted as one of key players in tumorigenesis and angiogenesis. Recently, several derivatives of psammaplin (Psams) from a marine sponge have been known to inhibit... -
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- Transcriptional induction of DLC-1 gene through Sp1 sites by histone deacetylase inhibitors in gastric cancer cells
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Kim TY, Kim IS, Jong HS, Lee JW, Kim TY, Jung M, Bang YJ
- KMID: 1072944
- Exp Mol Med.
- 2008 Dec;40(6):639-646.
- doi: 10.3858/emm.2008.40.6.639
We previously reported that trichostatin A (TSA), a histone deacetylase (HDAC) inhibitor, induced DLC-1 mRNA expression and accumulated acetylated histones H3 and H4 associated with the DLC-1 promoter in DLC-1... -
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- Histone deacetylase inhibitor KBH-A42 inhibits cytokine production in RAW 264.7 macrophage cells and in vivo endotoxemia model
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Choi Y, Park SK, Kim HM, Kang JS, Yoon YD, Han SB, Han JW, Yang JS, Han G
- KMID: 1104812
- Exp Mol Med.
- 2008 Oct;40(5):574-581.
- doi: 10.3858/emm.2008.40.5.574
In light of the anti-inflammatory properties of histone deacetylase (HDAC) inhibitors, such as suberoylanilide hydroxamic acid (SAHA) and trichostatin A (TSA), we examined a new HDAC inhibitor KBH-A42 for its... -
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