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Gynecomastia induced by H1-antihistamine (ebastine) in a patient with idiopathic anaphylaxis

Jung HS, Park CH, Park YT, Bae MA, Lee YI, Kang BJ, Jegal Y, Ahn JJ, Lee T

H1-antihistamine is generally a well-tolerated and safe drug. However, in resemblance with all other drugs, H1-antihistamines can also prompt adverse drug reactions (ADRs). We recently encountered the very unusual ADR...
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Synergistic Effect of H1-Antihistamines on Topical Corticosteroids for Pruritus in Atopic Dermatitis: A Systematic Review and Meta-Analysis

Hur MS, Choe YB, Ahn KJ, Lee YW

BACKGROUND: Although oral antihistamines (H1-histamine receptor antagonists) are the main treatment option for pruritus in general skin dermatosis, their effect in treating pruritus of atopic dermatitis (AD) has not yet...
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An overview and considerations in prescribing H1-antihistamine

Choi YS, Park YM, Rha YH, Choi SH

H1-antihistamines have been prescribed widely for the treatment of allergic diseases, such as rhinitis, atopic dermatitis, and urticaria besides common colds since the 1940s. H1-antihistamines are classified by chemical structures...
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Etiology and Treatment of Chronic Urticaria

Jee YK

Chronic urticaria is a well-known disease entity, characterized by the rapid appearance of frequently occurring, short-lived wheals, surrounded by a bright-red flare, and often accompanied by angioedema. Any pattern of...
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Effects of cetirizine in dogs with chronic atopic dermatitis: a randomized, double blind, placebo-controlled trial

Hsiao YH, Chen C, Willemse T

This study was conducted to evaluate the effects of cetirizine in dogs with atopic dermatitis (AD) while fulfilling Favrot's diagnostic clinical criteria. Dogs received either 3 mg/kg cetirizine (n =...
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A Case of Torsade de Pointes after Treatment with Terfenadine and Ketoconazole

Oh SK, Kuk H, Lim SB, Jeong JW, Park YK, Park OK

Torsade de pointes (TdP) is a form of polymorphic ventricular tachycardia that is associated with prolongation of the QT interval. Although it occurs in many clinical settings, torsade de pointes...
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Allergic rhinitis in children:diagnosis and treatment

Rha YH

Allergic rhinitis is a common disease of childhood characterized by nasal, throat, and ocular itching, rhinorrhea, sneezing, nasal congestion. Those affected with allergic rhinitis often suffer from associated inflammatory conditions...
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Effects of anti-allergic drugs on intestinal mastocytosis and worm expulsion of rats infected with Neodiplostomum seoulense

Shin EH, Kim TH, Hong SJ, Park JH, Guk SM, Chai JY

The effects of anti-allergic drugs on intestinal mastocytosis and the expulsion of Neodiplostomum seoulense were observed in Sprague-Dawley rats, after oral infection with 500 metacercariae. The drugs used were hydroxyzine...
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A case of levocetirizine-induced liver injury

Jung MC, Kim JK, Cho JY, Song JW, Lee B, Park JW, Seo J, Kim SE

Levocetirizine is a second-generation nonsedative antihistaminic agent that has been demonstrated to be safe and effective for treating allergic disease. There was only one case report of levocetirizine-induced liver toxicity,...
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Anaphylaxis audit in a busy metropolitan Emergency Department: a review of real life management compared to best practice

Murad A, Katelaris

BACKGROUND: Deficiencies in anaphylaxis management in Emergency Departments is well recognised despite established guidelines for its treatment. OBJECTIVE: To identify deficiencies in the management of anaphylaxis in a busy metropolitan Emergency...
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On the Degranulation of Mesenteric Mast Cells Caused by Antihistamine in Albino Rats: Effects of Various Dosages of Antihistamine

Kang HS, Pak SY, Choi KD

Degranulation of the mast cell has been reported by the injection of histamine liberators and other chemical agents. Chlorpheniramine maleate (1.2mg./kg. and 0.3mg./kg. comprising 1/74and 1/290 of LD50 respectively), which...
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Antihistamine Pretreatment to Reduce Incidence of Withdrawal Movement After Rocuronium Injection

Lee HJ, Han SJ, Kim H, Lee IO, Kong MH, Kim NS, Lim SH, Lee MK

The purpose of this study was to determine the effectiveness of antihistamine therapy for withdrawal movements caused by rocuronium injection. One hundred seventy one ASA I-II adults undergoing elective surgery...
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Acquired Perforating Dermatosis in Patients with Chronic Renal Failure and Diabetes Mellitus

Hong SB, Park JH, Ihm CG, Kim NI

Acquired perforating dermatosis (APD) is a skin disorder occurring in the patients with chronic renal failure (CRF), diabetes mellitus (DM) or both. The purpose of this study was to clarify...
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