- Rosmarinic Acid Attenuates Cell Damage against UVB Radiation-Induced Oxidative Stress via Enhancing Antioxidant Effects in Human HaCaT Cells
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Fernando P, Piao MJ, Kang KA, Ryu YS, Hewage SR, Chae SW, Hyun JW
- KMID: 2170544
- Biomol Ther.
- 2016 Jan;24(1):75-84.
- doi: 10.4062/biomolther.2015.069
This study was designed to investigate the cytoprotective effect of rosmarinic acid (RA) on ultraviolet B (UVB)-induced oxidative stress in HaCaT keratinocytes. RA exerted a significant cytoprotective effect by scavenging... -
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- Galangin Activates the ERK/AKT-Driven Nrf2 Signaling Pathway to Increase the Level of Reduced Glutathione in Human Keratinocytes
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Hewage SR, Piao MJ, Kang KA, Ryu YS, Fernando P, Oh MC, Park JE, Shilnikova K, Moon YJ, Shin DO, Hyun JW
- KMID: 2386910
- Biomol Ther.
- 2017 Jul;25(4):427-433.
- doi: 10.4062/biomolther.2016.112
Previously, we demonstrated that galangin (3,5,7-trihydroxyflavone) protects human keratinocytes against ultraviolet B (UVB)-induced oxidative damage. In this study, we investigated the effect of galangin on induction of antioxidant enzymes involved... -
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- Hesperidin Attenuates Ultraviolet B-Induced Apoptosis by Mitigating Oxidative Stress in Human Keratinocytes
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Hewage SR, Piao MJ, Kang KA, Ryu YS, Han X, Oh MC, Jung U, Kim IG, Hyun JW
- KMID: 2164224
- Biomol Ther.
- 2016 May;24(3):312-319.
- doi: 10.4062/biomolther.2015.139
Human skin cells undergo pathophysiological processes via generation of reactive oxygen species (ROS) upon excessive exposure to ultraviolet B (UVB) radiation. This study investigated the ability of hesperidin (C28H34O15) to... -
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- Baicalein Protects Human Skin Cells against Ultraviolet B-Induced Oxidative Stress
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Oh MC, Piao MJ, Fernando P, Han X, Hewage SR, Park JE, Ko MS, Jung U, Kim IG, Hyun JW
- KMID: 2374616
- Biomol Ther.
- 2016 Nov;24(6):616-622.
- doi: 10.4062/biomolther.2016.022
Baicalein (5,6,7-trihydroxy-2-phenyl-chromen-4-one) is a flavone, a type of flavonoid, originally isolated from the roots of Scutellaria baicalensis. This study evaluated the protective effects of baicalein against oxidative damage-mediated apoptosis induced... -
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