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Oxygen-Dependent and -Independent Regulation of HIF-1alpha

Chun YS, Kim MS, Park JW

Hypoxia-inducible factor-1 (HIF-1) is composed of HIF-1alpha and HIF-1beta, and is a master regulator of oxygen homeostasis, playing critical roles in physiological and pathological processes. Normally, the formation and...
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Angiogenesis and Mineralization During Distraction Osteogenesis

Choi IH, Chung CY, Cho TJ, Yoo WJ

Distraction osteogenesis is currently a standard method of bone lengthening. It is a viable method for the treatment of short extremities as well as extensive bone defects, because large amounts...
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Angiotensin II stimulates proliferation of adventitial fibroblasts cultured from rat aortic explants

Kim DK, Huh JE, Lee SH, Hong KP, Park JE, Seo JD, Lee WR

It has been proposed that the local renin-angiotensin system is activated in the adventitia after vascular injury. However, the physiological role of Angiotensin II (Ang II) in the adventitia has...
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Hypoxia-inducible factor (HIF-1)alpha: its protein stability and biological functions

Lee JW, Bae SH, Jeong JW, Kim SH, Kim KW

  • KMID: 755659
  • Exp Mol Med.
  • 2004 Feb;36(1):1-12.
Hypoxia-inducible factor (HIF-1) is an oxygen-dependent transcriptional activator, which plays crucial roles in the angiogenesis of tumors and mammalian development. HIF-1 consists of a constitutively expressed HIF-1beta subunit and one...
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