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Heterologous corneal endothelial cell transplantation: human corneal endothelial cell transplantation in Lewis rats

Tchah H

A heterologous corneal endothelial transplantation was attempted using human endothelial cells and a Lewis rat penetrating keratoplasty model. Cultured human endothelial cells were seeded to a Lewis rat cornea,...
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Interstitial mononuclear cell infiltrates in chronic rejection of the kidney and correlation with peripheral blood

Jeong HJ, Hong SW, Kim YS, Kim MS, Choi IH, Park K, Choi IJ

To investigate the characteristics of interstitial inflammatory cells and possible involvement of nudelta T cells, 16 renal allograft biopsies showing chronic rejection were stained by immunohistochemical method and correlated with...
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Two-signal blockade with anti-CD45RB and anti-CD154 monoclonal antibodies inhibits graft rejection via CD4-dependent mechanisms in allogeneic skin transplantation

Kim EY, Lee EN, Lee J, Park HJ, Chang CY, Jung DY, Choi SY, Lee SK, Joh JW, Kim SJ

  • KMID: 1094154
  • Exp Mol Med.
  • 2006 Jun;38(3):284-294.
Blockade of signal 1 or 2 for T-cell activation by the use of anti-CD45RB and anti-CD154 monoclonal antibodies (mAb) (two-signal blockade) has been proven effective in preventing or delaying graft...
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Increase in Anti-Gal IgM Level is Associated With Early Graft Failure in Intraportal Porcine Islet Xenotransplantation

Kang HJ, Lee H, Park EM, Kim JM, Shin JS, Kim JS, Park CG, Kim SJ

BACKGROUND: Anti-Gal is a major antibody induced in non-human primates (NHPs) after xenotransplantation. To understand the mechanism of graft rejection, we investigated the association between anti-Gal responses and graft failure...
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Subdominant H60 antigen-specific CD8 T-cell response precedes dominant H4 antigen-specific response during the initial phase of allogenic skin graft rejection

Yoo KI, Jeon JY, Ryu SJ, Nam G, Youn H, Choi EY

In allogeneic transplantation, including the B6 anti-BALB.B settings, H60 and H4 are two representative dominant minor histocompatibility antigens that induce strong CD8 T-cell responses. With different distribution patterns, H60 expression...
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DNA Microarray-Based Gene Expression Profiling in Porcine Keratocytes and Corneal Endothelial Cells and Comparative Analysis Associated with Xeno-related Rejection

Kim MK, Oh JY, Ko JH, Lee HJ, Jung JH, Wee WR, Lee JH, Park CG, Kim SJ, Ahn C, Kim SJ, Hwang SY

Porcine to rat corneal xenotransplantation resulted in severe inflammation and rejection of the corneal stroma, whereas an allograft showed mainly endothelial cell-associated rejection. We, therefore, investigated and compared the gene...
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