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The Current State and Future of Plasma Cell-Free DNA Analysis in Urologic Malignancies

Genomic medicine based on comprehensive genomic profiling (CGP) has revolutionized cancer treatment. However, there are certain limitations to CGP based on tissue analysis. Liquid biopsy, particularly plasma cell-free DNA (cfDNA),...
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Food Intake and Thermogenesis in Adipose Tissue

Goto T, Kim M, Takahashi , Takahashi , Kawada T

Brown adipose tissue (BAT) is regarded as a key target for developing interventions to prevent and treat obesity and age-related diseases. In addition, uncoupling pro tein 1 (UCP1) - expressing...
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Clear cell histology as a poor prognostic factor for advanced epithelial ovarian cancer: a single institutional case series through central pathologic review

Miyamoto M, Takano M, Goto T, Kato M, Sasaki N, Tsuda H, Furuya K

OBJECTIVE: Compared with serous adenocarcinoma (SAC), clear cell carcinoma (CCC) often shows chemo-resistance, which would potentially lead to a poor prognosis. On the other hand, there have been arguments over...
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Clinical Outcomes of Biliary Drainage during a Neoadjuvant Therapy for Pancreatic Cancer: Metal versus Plastic Stents

Kuwatani M, Nakamura T, Hayashi T, Kimura Y, Ono M, Motoya M, Imai K, Yamakita K, Goto T, Takahashi K, Maguchi H, Hirano S, Hokkaido Pancreatic Cancer Study Group (HOPS)

Neoadjuvant chemotherapy/neoadjuvant chemoradiotherapy (NAC/NACRT) can be performed in patients with pancreatic cancer to improve survival. We aimed to clarify the clinical outcomes of biliary drainage with a metal stent (MS)...
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Intra-individual comparison of liver stiffness measurements by magnetic resonance elastography and two-dimensional shear-wave elastography in 888 patients

Ichikawa H, Yasuda E, Kumada T, Takeshima K, Ogawa S, Tsunekawa A, Goto T, Nakaya K, Akita T, Tanaka J

Purpose: Quantitative elastography methods, such as ultrasound two-dimensional shear-wave elastography (2D-SWE) and magnetic resonance elastography (MRE), are used to diagnose liver fibrosis. The present study compared liver stiffness determined by...
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DNA mismatch repair-related protein loss as a prognostic factor in endometrial cancers

Kato M, Takano M, Miyamoto M, Sasaki N, Goto T, Tsuda H, Furuya K

OBJECTIVE: Recent investigations have revealed DNA mismatch repair (MMR) gene mutations are closely related with carcinogenesis of endometrial cancer; however the impact of MMR protein expression on prognosis is not...
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