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Regulation of Type IV Collagen alpha Chains of Glomerular Epithelial Cells in Diabetic Conditions

Ha TS, Hong EJ, Ahn EM, Ahn HY

An early feature of diabetic nephropathy is the alteration of the glomerular basement membrane (GBM), which may result in microalbuminuria, subsequent macroproteinuria, and eventual chronic renal failure. Although type IV...
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Effect of Advanced Glycation End Products on Oxidative Stress and Senescence of Trabecular Meshwork Cells

Park CH, Kim JW

PURPOSE: To investigate the effect of advanced glycation end products (AGE) on oxidative stress and cellular senescence in cultured human trabecular meshwork cells (HTMC). METHODS: Primarily cultured HTMC were exposed to...
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Long-Term Exercise Training Attenuates Age-Related Diastolic Dysfunction: Association of Myocardial Collagen Cross-Linking

Choi SY, Chang HJ, Choi SI, Kim KI, Cho YS, Youn TJ, Chung WY, Chae IH, Choi DJ, Kim HS, Kim CH, Oh BH, Kim MH

The incidence of diastolic heart failure increases dramatically with age. We investigated the impact of long-term exercise training on age-related diastolic dysfunction. Old (25-month-old) male Fischer 344 rats were studied...
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