- Protective mechanism of glucose against alloxan-induced beta-cell damage: pivotal role of ATP
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Rho HW, Lee JN, Kim HR, Park BH, Park JW
- KMID: 927128
- Exp Mol Med.
- 2000 Mar;32(1):12-17.
Glucose prevents the development of diabetes induced by alloxan. In the present study, the protective mechanism of glucose against alloxan-induced beta-cell damage was investigated using HIT-T 15 cell, a Syrian... -
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- Effects of Protein Source and Energy Substrates on the In Vitro Development of Bovine Embryos in a Two-step Culture System
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Lim KT, Lee BC, Kang SK, Hwang WS
- KMID: 1099824
- J Vet Sci.
- 2003 Apr;4(1):73-78.
In this study, we examined the effects of a two-step culture system, which involves the use of different culture media for early cleavage and later stage embryos, on the in... -
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- Expression and Regulation of Latent TGF-beta Binding Protein-1 Transcripts and Their Splice Variants in Human Glomerular Endothelial Cells
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Kwak JH, Woo JS, Shin K, Kim HJ, Jeong HS, Han DC, Kim SI, Park CS
- KMID: 1712745
- J Korean Med Sci.
- 2005 Aug;20(4):628-635.
- doi: 10.3346/jkms.2005.20.4.628
Latent transforming growth factor (TGF)-beta-binding protein (LTBP) is required for the assembly, secretion, matrix association, and activation of latent TGF-beta complex. To elucidate the cell specific expression of the genes... -
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- Characterization of regulatory elements on the promoter region of human ATP-citrate lyase
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Moon YA, Kim KS, Cho UH, Yoon DJ, Park SW
- KMID: 1029940
- Exp Mol Med.
- 1999 Jun;31(2):108-114.
ATP-citrate lyase (ACL), an enzyme catalyzing the first step in biosynthesis of fatty acids, is induced during the lipogenesis and cholesterologenesis. We demonstrate that the region -213 to -128 of human ACL... -
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- Regulation of ATP-citrate lyase gene transcription
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Kim KS, Kang JG, Moon YA, Park SW, Kim YS
- KMID: 699895
- Yonsei Med J.
- 1996 Jun;37(3):214-224.
- doi: 10.3349/ymj.1996.37.3.214
It has been suggested that glucose metabolites and insulin are the most important factors inducing ATP-citrate lyase (ACL) by a high carbohydrate diet. We have used a primary culture of... -
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- Studies on the Hepatic Accumulation of Triglyceride Induced by Chronic Ethanol Administration in Rats Fed with Various Diets
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Cho MY, Choi BS, Kim YS
- KMID: 692892
- Yonsei Med J.
- 1980 Jun;21(1):9-17.
- doi: 10.3349/ymj.1980.21.1.9
Investigation in our laboratory has been undertaken to study the effect of ethanol on the triglyceride (TG) content in the liver, the free fatty acid (FFA) content in the serum... -
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- Coptidis rhizoma extract protects against cytokine-induced death of pancreatic beta-cells through suppression of NF-kappa B activation
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Kim EK, Kwon KB, Han MJ, Song MY, Lee JH, Lv N, Ka SO, Yeom SR, Kwon YD, Ryu DG, Kim KS, Park JW, Park R, Park BH
- KMID: 1094655
- Exp Mol Med.
- 2007 Apr;39(2):149-159.
We demonstrated previously that Coptidis rhizoma extract (CRE) prevented S-nitroso-N-acetylpenicillamine-induced apoptotic cell death via the inhibition of mitochondrial membrane potential disruption and cytochrome c release in RINm5F (RIN) rat insulinoma... -
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- Effective glycemic control achieved by transplanting non-viral cationic liposome-mediated VEGF-transfected islets in streptozotocin-induced diabetic mice
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Chae HY, Lee BW, Oh SH, Ahn YR, Chung JH, Min YK, Lee MS, Lee MK, Kim KW
- KMID: 1116196
- Exp Mol Med.
- 2005 Dec;37(6):513-523.
Hypoxic damage is one of the major causes of islet graft failure and VEGF is known to play a crucial role in revascularization. To address the effectiveness of a cationic... -
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