- Computational approaches for molecular characterization and structure-based functional elucidation of a hypothetical protein from Mycobacterium tuberculosis
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Saikat ASM
- KMID: 2543704
- Genomics Inform.
- 2023 Jun;21(2):e25.
- doi: 10.5808/gi.23001
Adaptation of infections and hosts has resulted in several metabolic mechanisms adopted by intracellular pathogens to combat the defense responses and the lack of fuel during infection. Human tuberculosis caused... -
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- Assessing the impact of recombination on the estimation of isolation-with-migration models using genomic data: a simulation study
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Chung Y
- KMID: 2543706
- Genomics Inform.
- 2023 Jun;21(2):e27.
- doi: 10.5808/gi.23016
Recombination events complicate the evolutionary history of populations and species and have a significant impact on the inference of isolation-with-migration (IM) models. However, several existing methods have been developed, assuming... -
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- COVID-19 progression towards ARDS: a genome wide study reveals host factors underlying critical COVID-19
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Mujawar S, Patil G, Suthar S, Shendkar T, Gangadhar V
- KMID: 2543695
- Genomics Inform.
- 2023 Jun;21(2):e16.
- doi: 10.5808/gi.22080
Coronavirus disease 2019 (COVID-19) is a viral infection produced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus epidemic, which was declared a global pandemic in March 2020. The... -
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- Functional annotation of uncharacterized proteins from Fusobacterium nucleatum: identification of virulence factors
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Rauthan K, Joshi S, Kumar L, Goel D, Kumar S
- KMID: 2543700
- Genomics Inform.
- 2023 Jun;21(2):e21.
- doi: 10.5808/gi.22065
Fusobacterium nucleatum is a gram-negative bacteria associated with diverse infections like appendicitis and colorectal cancer. It mainly attacks the epithelial cells in the oral cavity and throat of the infected... -
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- e-Pharmacophore modeling and in silico study of CD147 receptor against SARS-CoV-2 drugs
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Pandit NK, Mann SS, Mohanty A, Meena SS
- KMID: 2543696
- Genomics Inform.
- 2023 Jun;21(2):e17.
- doi: 10.5808/gi.23005
Coronavirus has left severe health impacts on the human population, globally. Still a significant number of cases are reported daily as no specific medications are available for its effective treatment.... -
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- Cell line-specific features of 3D chromatin organization in hepatocellular carcinoma
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Kim Y, Yang H, Lee D
- KMID: 2543698
- Genomics Inform.
- 2023 Jun;21(2):e19.
- doi: 10.5808/gi.23015
Liver cancer, particularly hepatocellular carcinoma (HCC), poses a significant global threat to human lives. To advance the development of innovative diagnostic and treatment approaches, it is essential to examine the... -
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- Insight from sirtuins interactome: topological prominence and multifaceted roles of SIRT1 in modulating immunity, aging and cancer
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Zulkifli ND, Zulkifle N
- KMID: 2543702
- Genomics Inform.
- 2023 Jun;21(2):e23.
- doi: 10.5808/gi.23003
The mammalian sirtuin family, consisting of SIRT1–SIRT7, plays a vital role in various biological processes, including cancer, diabetes, neurodegeneration, cardiovascular disease, cellular metabolism, and cellular homeostasis maintenance. Due to their... -
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- The genomic landscape associated with resistance to aromatase inhibitors in breast cancer
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Sadasivam K, Manoharan JP, Palanisamy H, Vidyalakshmi S
- KMID: 2543699
- Genomics Inform.
- 2023 Jun;21(2):e20.
- doi: 10.5808/gi.23012
Aromatase inhibitors (AI) are drugs that are widely used in treating estrogen receptor (ER)–positive breast cancer patients. Drug resistance is a major obstacle to aromatase inhibition therapy. There are diverse... -
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- Comparison of digital PCR platforms using the molecular marker
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Lee CJ, Shin W, Song M, Shin SS, Park Y, Srikulnath K, Kim DH, Han K
- KMID: 2543703
- Genomics Inform.
- 2023 Jun;21(2):e24.
- doi: 10.5808/gi.23008
Assays of clinical diagnosis and species identification using molecular markers are performed according to a quantitative method in consideration of sensitivity, cost, speed, convenience, and specificity. However, typical polymerase chain... -
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- Bioinformatic analyses reveal the prognostic significance and potential role of ankyrin 3 (ANK3) in kidney renal clear cell carcinoma
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Somsuan K, Aluksanasuwan S
- KMID: 2543701
- Genomics Inform.
- 2023 Jun;21(2):e22.
- doi: 10.5808/gi.23013
Kidney renal clear cell carcinoma (KIRC) is one of the most aggressive cancer type of the urinary system. Metastatic KIRC patients have poor prognosis and limited therapeutic options. Ankyrin 3... -
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- A bioinformatic approach to identify pathogenic variants for Stevens-Johnson syndrome
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Ma’ruf M, Fadli JC, Mahendra MR, Irham LM, Sulistyani N, Adikusuma W, Chong R, Septama AW
- KMID: 2543705
- Genomics Inform.
- 2023 Jun;21(2):e26.
- doi: 10.5808/gi.23010
Stevens-Johnson syndrome (SJS) produces a severe hypersensitivity reaction caused by Herpes simplex virus or mycoplasma infection, vaccination, systemic disease, or other agents. Several studies have investigated the genetic susceptibility involved... -
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- Single-cell RNA sequencing identifies distinct transcriptomic signatures between PMA/ionomycin- and αCD3/αCD28-activated primary human T cells
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Lee JH, Lee BH, Jeong S, Joh CSY, Nam HJ, Choi HS, Sserwadda H, Oh JW, Park CG, Jin SP, Kim HJ
- KMID: 2543697
- Genomics Inform.
- 2023 Jun;21(2):e18.
- doi: 10.5808/gi.23009
Immunologists have activated T cells in vitro using various stimulation methods, including phorbol myristate acetate (PMA)/ionomycin and αCD3/αCD28 agonistic antibodies. PMA stimulates protein kinase C, activating nuclear factor-κB, and ionomycin... -
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