- Editor’s introduction to this issue (G&I 19:1, 2021)
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Park T
- KMID: 2514705
- Genomics Inform.
- 2021 Mar;19(1):e1.
- doi: 10.5808/gi.21191
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- Computational evaluation of interactions between olfactory receptor OR2W1 and its ligands
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Oh SJ
- KMID: 2514713
- Genomics Inform.
- 2021 Mar;19(1):e9.
- doi: 10.5808/gi.21026
Mammalian olfactory receptors are a family of G protein‒coupled receptors (GPCRs) that occupy a large part of the genome. In human genes, olfactory receptors account for more than 40% of... -
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- In silico discovery and evaluation of phytochemicals binding mechanism against human catechol-Omethyltransferase as a putative bioenhancer of L-DOPA therapy in Parkinson disease
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- KMID: 2514711
- Genomics Inform.
- 2021 Mar;19(1):e7.
- doi: 10.5808/gi.20061
Levodopa (L-DOPA) therapy is normally practised to treat motor pattern associated with Parkinson disease (PD). Additionally, several inhibitory drugs such as Entacapone and Opicapone are also cosupplemented to protect peripheral... -
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- De novo assembly, annotation and gene expression profiles of gonads of Cytorace-3, a hybrid lineage of Drosophila nasuta nasuta and D. n. albomicans
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Ponnanna K, DSouza SM, Ramachandra NB
- KMID: 2514712
- Genomics Inform.
- 2021 Mar;19(1):e8.
- doi: 10.5808/gi.20051
Cytorace-3 is a laboratory evolved hybrid lineage of Drosophila nasuta nasuta males and Drosophila nasuta albomicans females currently passing ~850 generations. To assess interracial hybridization effects on gene expression in... -
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- Functional annotation of lung cancer‒associated genetic variants by cell type‒specific epigenome and long-range chromatin interactome
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Lee AJ, Jung I
- KMID: 2514707
- Genomics Inform.
- 2021 Mar;19(1):e3.
- doi: 10.5808/gi.20073
Functional interpretation of noncoding genetic variants associated with complex human diseases and traits remains a challenge. In an effort to enhance our understanding of common germline variants associated with lung... -
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- Forecasting of the COVID-19 pandemic situation of Korea
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Goo T, Apio C, Heo G, Lee D, Lee JH, Lim J, Han K, Park T
- KMID: 2514715
- Genomics Inform.
- 2021 Mar;19(1):e11.
- doi: 10.5808/gi.21028
For the novel coronavirus disease 2019 (COVID-19), predictive modeling, in the literature, uses broadly susceptible exposed infected recoverd (SEIR)/SIR, agent-based, curve-fitting models. Governments and legislative bodies rely on insights from... -
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- Identification of potential candidate genes for lip and oral cavity cancer using network analysis
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Mathavan S, Kue CS, Kumar S
- KMID: 2514708
- Genomics Inform.
- 2021 Mar;19(1):e4.
- doi: 10.5808/gi.20062
Lip and oral cavity cancer, which can occur in any part of the mouth, is the 11th most common type of cancer worldwide. The major obstacles to patients’ survival are... -
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- Machine learning based anti-cancer drug response prediction and search for predictor genes using cancer cell line gene expression
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Qiu K, Lee J, Kim H, Yoon S, Kang K
- KMID: 2514714
- Genomics Inform.
- 2021 Mar;19(1):e10.
- doi: 10.5808/gi.20076
Although many models have been proposed to accurately predict the response of drugs in cell lines recent years, understanding the genome related to drug response is also the key for... -
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- Screening of novel alkaloid inhibitors for vascular endothelial growth factor in cancer cells: an integrated computational approach
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Shahik SM, Salauddin A, Hossain MS, Noyon SH, Moin AT, Mizan S, Raza MT
- KMID: 2514710
- Genomics Inform.
- 2021 Mar;19(1):e6.
- doi: 10.5808/gi.20068
Vascular endothelial growth factor (VEGF) is expressed at elevated levels by most cancer cells, which can stimulate vascular endothelial cell growth, survival, proliferation as well as trigger angiogenesis modulated by... -
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- Elucidating molecular mechanisms of acquired resistance to BRAF inhibitors in melanoma using a microfluidic device and deep sequencing
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Han J, Jung Y, Jun Y, Park S, Lee S
- KMID: 2514706
- Genomics Inform.
- 2021 Mar;19(1):e2.
- doi: 10.5808/gi.20074
BRAF inhibitors (e.g., vemurafenib) are widely used to treat metastatic melanoma with the BRAF V600E mutation. The initial response is often dramatic, but treatment resistance leads to disease progression in... -
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- Genetic alterations in Wnt family of genes and their putative association with head and neck squamous cell carcinoma
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Aditya J, A. S. Smiline G, Paramasivam A, Vijayashree PJ
- KMID: 2514709
- Genomics Inform.
- 2021 Mar;19(1):e5.
- doi: 10.5808/gi.20065
Head and neck squamous cell carcinoma (HNSCC) is the most frequent type of head and neck cancer that usually arises from the mucosal surfaces of several organs including nasal cavity,... -
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