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IVAG: An Integrative Visualization Application for Various Types of Genomic Data Based on R-Shiny and the Docker Platform

Lee TR, Ahn JM, Kim G, Kim S

Next-generation sequencing (NGS) technology has become a trend in the genomics research area. There are many software programs and automated pipelines to analyze NGS data, which can ease the pain...
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HOTAIR Long Non-coding RNA: Characterizing the Locus Features by the In Silico Approaches

Hajjari M, Rahnama S

HOTAIR is an lncRNA that has been known to have an oncogenic role in different cancers. There is limited knowledge of genetic and epigenetic elements and their interactions for the...
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Prediction of Metal Ion Binding Sites in Proteins from Amino Acid Sequences by Using Simplified Amino Acid Alphabets and Random Forest Model

Kumar S

Metal binding proteins or metallo-proteins are important for the stability of the protein and also serve as co-factors in various functions like controlling metabolism, regulating signal transport, and metal homeostasis....
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Classification of Genes Based on Age-Related Differential Expression in Breast Cancer

Lee G, Lee M

Transcriptome analysis has been widely used to make biomarker panels to diagnose cancers. In breast cancer, the age of the patient has been known to be associated with clinical features....
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Identification of New Potential APE1 Inhibitors by Pharmacophore Modeling and Molecular Docking

Lee IW, Yoon J, Lee G, Lee M

Apurinic/apyrimidinic endonuclease 1 (APE1) is an enzyme responsible for the initial step in the base excision repair pathway and is known to be a potential drug target for treating cancers,...
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Structural Analysis of Recombinant Human Preproinsulins by Structure Prediction, Molecular Dynamics, and Protein-Protein Docking

Jung SH, Kim CK, Lee G, Yoon J, Lee M

More effective production of human insulin is important, because insulin is the main medication that is used to treat multiple types of diabetes and because many people are suffering from...
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Validation of Customized Cancer Panel for Detecting Somatic Mutations and Copy Number Alterations

Choi SH, Jung SH, Chung YJ

Accurate detection of genomic alterations, especially druggable hotspot mutations in tumors, has become an essential part of precision medicine. With targeted sequencing, we can obtain deeper coverage of reads and...
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misMM: An Integrated Pipeline for Misassembly Detection Using Genotyping-by-Sequencing and Its Validation with BAC End Library Sequences and Gene Synteny

Ko YJ, Kim JS, Kim S

As next-generation sequencing technologies have advanced, enormous amounts of whole-genome sequence information in various species have been released. However, it is still difficult to assemble the whole genome precisely, due...
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Synonymous Codon Usage Controls Various Molecular Aspects

Im EH, Choi SS

Synonymous sites are generally considered to be functionally neutral. However, there are recent contradictory findings suggesting that synonymous alleles might have functional roles in various molecular aspects. For instance, a...
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CTCF, Cohesin, and Chromatin in Human Cancer

Song SH, Kim TY

It is becoming increasingly clear that eukaryotic genomes are subjected to higher-order chromatin organization by the CCCTC-binding factor/cohesin complex. Their dynamic interactions in three dimensions within the nucleus regulate gene...
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Editor’s Introduction to This Issue (G&I 15:4, 2017)

Chung YJ

No abstract available.
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