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Mining the Proteome of Fusobacterium nucleatum subsp. nucleatum ATCC 25586 for Potential Therapeutics Discovery: An In Silico Approach

Habib AM, Islam MS, Sohel M, Mazumder M, Sikder MO, Shahik SM

The plethora of genome sequence information of bacteria in recent times has ushered in many novel strategies for antibacterial drug discovery and facilitated medical science to take up the challenge...
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Drug Target Identification and Elucidation of Natural Inhibitors for Bordetella petrii: An In Silico Study

Rath SN, Ray M, Pattnaik A, Pradhan SK

Environmental microbes like Bordetella petrii has been established as a causative agent for various infectious diseases in human. Again, development of drug resistance in B. petrii challenged to combat against...
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Tissue Specific Expression Levels of Apoptosis Involved Genes Have Correlations with Codon and Amino Acid Usage

Hajjari M, Sadeghi I, Salavaty A, Nasiri H, Birgani MT

Different mechanisms, including transcriptional and post transcriptional processes, regulate tissue specific expression of genes. In this study, we report differences in gene/protein compositional features between apoptosis involved genes selectively expressed...
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Demographic Trends in Korean Native Cattle Explained Using Bovine SNP50 Beadchip

Sharma A, Lim D, Chai HH, Choi BH, Cho Y

Linkage disequilibrium (LD) is the non-random association between the loci and it could give us a preliminary insight into the genetic history of the population. In the present study LD...
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Metabolic Pathways Associated with Kimchi, a Traditional Korean Food, Based on In Silico Modeling of Published Data

Shin GH, Kang BC, Jang DJ

Kimchi is a traditional Korean food prepared by fermenting vegetables, such as Chinese cabbage and radishes, which are seasoned with various ingredients, including red pepper powder, garlic, ginger, green onion,...
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Identification of a Copy Number Variation on Chromosome 20q13.12 Associated with Osteoporotic Fractures in the Korean Population

Park TJ, Hwang MY, Moon S, Hwang JY, Go MJ, Kim BJ

Osteoporotic fractures (OFs) are critical hard outcomes of osteoporosis and are characterized by decreased bone strength induced by low bone density and microarchitectural deterioration in bone tissue. Most OFs cause...
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Investigation of Splicing Quantitative Trait Loci in Arabidopsis thaliana

Yoo W, Kyung S, Han S, Kim S

The alteration of alternative splicing patterns has an effect on the quantification of functional proteins, leading to phenotype variation. The splicing quantitative trait locus (sQTL) is one of the main...
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Interleukin-10 Polymorphisms in Association with Prognosis in Patients with B-Cell Lymphoma Treated by R-CHOP

Kim MK, Yoon KA, Park EY, Joo J, Lee EY, Eom HS, Kong SY

Interleukin-10 (IL10) plays an important role in initiating and maintaining an appropriate immune response to non-Hodgkin lymphoma (NHL). Previous studies have revealed that the transcription of IL10 mRNA and its...
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Effects of Single Nucleotide Polymorphism Marker Density on Haplotype Block Partition

Kim SA, Yoo YJ

Many researchers have found that one of the most important characteristics of the structure of linkage disequilibrium is that the human genome can be divided into non-overlapping block partitions in...
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Multiple Group Testing Procedures for Analysis of High-Dimensional Genomic Data

Ko H, Kim K, Sun H

In genetic association studies with high-dimensional genomic data, multiple group testing procedures are often required in order to identify disease/trait-related genes or genetic regions, where multiple genetic sites or variants...
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Genetic Association Analysis of Fasting and 1- and 2-Hour Glucose Tolerance Test Data Using a Generalized Index of Dissimilarity Measure for the Korean Population

Yee J, Kim Y, Park T, Park M

Glucose tolerance tests have been devised to determine the speed of blood glucose clearance. Diabetes is often tested with the standard oral glucose tolerance test (OGTT), along with fasting glucose...
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Comparison of Two Meta-Analysis Methods: Inverse-Variance-Weighted Average and Weighted Sum of Z-Scores

Lee CH, Cook S, Lee JS, Han B

The meta-analysis has become a widely used tool for many applications in bioinformatics, including genome-wide association studies. A commonly used approach for meta-analysis is the fixed effects model approach, for...
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Gene-Gene Interaction Analysis for the Accelerated Failure Time Model Using a Unified Model-Based Multifactor Dimensionality Reduction Method

Lee S, Son D, Yu W, Park T

Although a large number of genetic variants have been identified to be associated with common diseases through genome-wide association studies, there still exits limitations in explaining the missing heritability. One...
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Efficient Strategy to Identify Gene-Gene Interactions and Its Application to Type 2 Diabetes

Li D, Won S

Over the past decade, the detection of gene-gene interactions has become more and more popular in the field of genome-wide association studies (GWASs). The goal of the GWAS is to...
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Prediction of Quantitative Traits Using Common Genetic Variants: Application to Body Mass Index

Bae S, Choi S, Kim SM, Park T

With the success of the genome-wide association studies (GWASs), many candidate loci for complex human diseases have been reported in the GWAS catalog. Recently, many disease prediction models based on...
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Risk Prediction Using Genome-Wide Association Studies on Type 2 Diabetes

Choi S, Bae S, Park T

The success of genome-wide association studies (GWASs) has enabled us to improve risk assessment and provide novel genetic variants for diagnosis, prevention, and treatment. However, most variants discovered by GWASs...
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Editor's Introduction to This Issue

Park T

No abstract available.
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