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ERRATUM: Figure Legend Correction. Characteristics in Molecular Vibrational Frequency Patterns between Agonists and Antagonists of Histamine Receptors

Oh SJ

The legend of Figure 1 was given incorrectly. Histidine should be corrected as histamine.
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siMacro: A Fast and Easy Data Processing Tool for Cell-Based Genomewide siRNA Screens

Singh NK, Seo BY, Vidyasagar M, White MA, Kim HS

Growing numbers of studies employ cell line-based systematic short interfering RNA (siRNA) screens to study gene functions and to identify drug targets. As multiple sources of variations that are unique...
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Eukaryotic DNAJ/K Database: A Comprehensive Phylogenomic Analysis Platform for the DNAJ/K Family

Cheong K, Choi J, Choi J, Park J, Jang S, Lee YH

Proteins in DNAJ/K families are ubiquitous, from prokaryotes to eukaryotes, and function as molecular chaperones. For systematic phylogenomics of the DNAJ/K families, we developed the Eukaryotic DNAJ/K Database (EDD). A...
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Genetic Risk Prediction for Normal-Karyotype Acute Myeloid Leukemia Using Whole-Exome Sequencing

Heo SG, Hong EP, Park JW

Normal-karyotype acute myeloid leukemia (NK-AML) is a highly malignant and cytogenetically heterogeneous hematologic cancer. We searched for somatic mutations from 10 pairs of tumor and normal cells by using a...
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Annotation of Genes Having Candidate Somatic Mutations in Acute Myeloid Leukemia with Whole-Exome Sequencing Using Concept Lattice Analysis

Lee KH, Lim JH, Kim JH

In cancer genome studies, the annotation of newly detected oncogene/tumor suppressor gene candidates is a challenging process. We propose using concept lattice analysis for the annotation and interpretation of genes...
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Effects of Somatic Mutations Are Associated with SNP in the Progression of Individual Acute Myeloid Leukemia Patient: The Two-Hit Theory Explains Inherited Predisposition to Pathogenesis

Park S, Koh Y, Yoon SS

This study evaluated the effects of somatic mutations and single nucleotide polymorphisms (SNPs) on disease progression and tried to verify the two-hit theory in cancer pathogenesis. To address this issue,...
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Bioinformatics Interpretation of Exome Sequencing: Blood Cancer

Kim J, Lee YG, Kim N

We had analyzed 10 exome sequencing data and single nucleotide polymorphism chips for blood cancer provided by the PGM21 (The National Project for Personalized Genomic Medicine) Award program. We had...
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Association between Interferon-Inducible Protein 6 (IFI6) Polymorphisms and Hepatitis B Virus Clearance

Park GH, Kim KY, Cho SW, Cheong JY, Yu GI, Shin DH, Kwack KB

CD8+ T cells are key factors mediating hepatitis B virus (HBV) clearance. However, these cells are killed through HBV-induced apoptosis during the antigen-presenting period in HBV-induced chronic liver disease (CLD)...
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Perspectives of International Human Epigenome Consortium

Bae JB

As the International Human Epigenome Consortium (IHEC) launched officially at the 2010 Washington meeting, a giant step toward the conquest of unexplored regions of the human genome has begun. IHEC...
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ENCODE: A Sourcebook of Epigenomes and Chromatin Language

Yavartanoo M, Choi JK

Until recently, since the Human Genome Project, the general view has been that the majority of the human genome is composed of junk DNA and has little or no selective...
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Editor's Introduction to This Issue

Kim S

No abstract available.
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