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hpvPDB: An Online Proteome Reserve for Human Papillomavirus

Kumar S, Jena L, Daf S, Mohod K, Goyal P, Varma AK

Human papillomavirus (HPV) infection is the leading cause of cancer mortality among women worldwide. The molecular understanding of HPV proteins has significant connotation for understanding their intrusion in the host...
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Molecular Vibration-Activity Relationship in the Agonism of Adenosine Receptors

Chee HK, Oh SJ

The molecular vibration-activity relationship in the receptor-ligand interaction of adenosine receptors was investigated by structure similarity, molecular vibration, and hierarchical clustering in a dataset of 46 ligands of adenosine receptors....
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Forensic Body Fluid Identification by Analysis of Multiple RNA Markers Using NanoString Technology

Park JL, Park SM, Kim JH, Lee HC, Lee SH, Woo KM, Kim SY

RNA analysis has become a reliable method of body fluid identification for forensic use. Previously, we developed a combination of four multiplex quantitative PCR (qRT-PCR) probes to discriminate four different...
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Phylogeny of Flavobacteria Group Isolated from Freshwater Using Multilocus Sequencing Analysis

Mun S, Lee J, Lee S, Han K, Ahn TY

Sequence analysis of the 16S rRNA gene has been widely used for the classification of microorganisms. However, we have been unable to clearly identify five Flavobacterium species isolated from a...
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TT Mutant Homozygote of Kruppel-like Factor 5 Is a Key Factor for Increasing Basal Metabolic Rate and Resting Metabolic Rate in Korean Elementary School Children

Choi JR, Kwon IS, Kwon DY, Kim MS, Lee M

We investigated the contribution of genetic variations of KLF5 to basal metabolic rate (BMR) and resting metabolic rate (RMR) and the inhibition of obesity in Korean children. A variation of...
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Genetic Variations of ABCC2 Gene Associated with Adverse Drug Reactions to Valproic Acid in Korean Epileptic Patients

Yi JH, Cho YJ, Kim WJ, Lee MG, Lee JH

The multidrug resistance protein 2 (MRP2, ABCC2) gene may determine individual susceptibility to adverse drug reactions (ADRs) in the central nervous system (CNS) by limiting brain access of antiepileptic drugs,...
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Characterization of H460R, a Radioresistant Human Lung Cancer Cell Line, and Involvement of Syntrophin Beta 2 (SNTB2) in Radioresistance

Im CN, Kim BM, Moon EY, Hong DW, Park JW, Hong SH

A radioresistant cell line was established by fractionated ionizing radiation (IR) and assessed by a clonogenic assay, flow cytometry, and Western blot analysis, as well as zymography and a wound...
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Somatic Mutaome Profile in Human Cancer Tissues

Kim N, Hong Y, Kwon D, Yoon S

Somatic mutation is a major cause of cancer progression and varied responses of tumors against anticancer agents. Thus, we must obtain and characterize genome-wide mutational profiles in individual cancer subtypes....
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Study of Modern Human Evolution via Comparative Analysis with the Neanderthal Genome

Ahmed M, Liang P

Many other human species appeared in evolution in the last 6 million years that have not been able to survive to modern times and are broadly known as archaic humans,...
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Receptor for Advanced Glycation Endproducts (RAGE), Its Ligands, and Soluble RAGE: Potential Biomarkers for Diagnosis and Therapeutic Targets for Human Renal Diseases

Lee EJ, Park JH

Receptor for advanced glycation endproducts (RAGE) is a multi-ligand receptor that is able to bind several different ligands, including advanced glycation endproducts, high-mobility group protein (B)1 (HMGB1), S-100 calcium-binding protein,...
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Introduction to International Ethical Standards Related to Genetics and Genomics

Yim SH, Chung YJ

The rapid advances in genetic knowledge and technology raise various, sometimes unprecedented, ethical dilemmas in the scientific community as well as the public realm. To deal with these dilemmas, the...
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Current Status, Challenges, Policies, and Bioethics of Biobanks

Kang B, Park J, Cho S, Lee M, Kim N, Min H, Lee S, Park O, Han B

Many biobanks were established as biorepositories for biomedical research, and a number of biobanks were founded in the 1990s. The main aim of the biobank is to store and to...
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Review of Biological Network Data and Its Applications

Yu D, Kim M, Xiao G, Hwang TH

Studying biological networks, such as protein-protein interactions, is key to understanding complex biological activities. Various types of large-scale biological datasets have been collected and analyzed with high-throughput technologies, including DNA...
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A Primer for Disease Gene Prioritization Using Next-Generation Sequencing Data

Wang S, Xing J

High-throughput next-generation sequencing (NGS) technology produces a tremendous amount of raw sequence data. The challenges for researchers are to process the raw data, to map the sequences to genome, to...
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Perspectives on Clinical Informatics: Integrating Large-Scale Clinical, Genomic, and Health Information for Clinical Care

Choi IY, Kim TM, Kim MS, Mun SK, Chung YJ

The advances in electronic medical records (EMRs) and bioinformatics (BI) represent two significant trends in healthcare. The widespread adoption of EMR systems and the completion of the Human Genome Project...
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Genomic Profiling of Liver Cancer

Lee JS

Development of liver cancers is driven largely by genomic alterations that deregulate signaling pathways, influencing growth and survival of cancer cells. Because of the hundreds or thousands of genomic/epigenomic alterations...
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Application of Cancer Genomics to Solve Unmet Clinical Needs

Lee SH, Sim SH, Kim JY, Cha S, Song A

The large amount of data on cancer genome research has contributed to our understanding of cancer biology. Indeed, the genomics approach has a strong advantage for analyzing multi-factorial and complicated...
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Interplay between Epigenetics and Genetics in Cancer

Choi JD, Lee JS

Genomic instability, which occurs through both genetic mechanisms (underlying inheritable phenotypic variations caused by DNA sequence-dependent alterations, such as mutation, deletion, insertion, inversion, translocation, and chromosomal aneuploidy) and epigenomic aberrations...
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Editor's Introduction to This Issue

Kim S

No abstract available.
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