- Perspectives of Integrative Cancer Genomics in Next Generation Sequencing Era
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Kwon SM, Cho H, Choi JH, Jee BA, Jo Y, Woo HG
- KMID: 2166487
- Genomics Inform.
- 2012 Jun;10(2):69-73.
- doi: 10.5808/GI.2012.10.2.69
The explosive development of genomics technologies including microarrays and next generation sequencing (NGS) has provided comprehensive maps of cancer genomes, including the expression of mRNAs and microRNAs, DNA copy numbers,... -
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- Characteristics in Molecular Vibrational Frequency Patterns between Agonists and Antagonists of Histamine Receptors
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Oh SJ
- KMID: 2166496
- Genomics Inform.
- 2012 Jun;10(2):128-132.
- doi: 10.5808/GI.2012.10.2.128
To learn the differences between the structure-activity relationship and molecular vibration-activity relationship in the ligand-receptor interaction of the histamine receptor, 47 ligands of the histamine receptor were analyzed by structural... -
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- Alternative Splicing and Its Impact as a Cancer Diagnostic Marker
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Kim YJ, Kim HS
- KMID: 2166488
- Genomics Inform.
- 2012 Jun;10(2):74-80.
- doi: 10.5808/GI.2012.10.2.74
Most genes are processed by alternative splicing for gene expression, resulting in the complexity of the transcriptome in eukaryotes. It allows a limited number of genes to encode various proteins... -
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- Replication of the Association of the 6q22.31c Locus near GJA1 with Pulse Rate in the Korean Population
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Kim NH, Kim YJ, Oh JH, Cho YS
- KMID: 2166492
- Genomics Inform.
- 2012 Jun;10(2):106-109.
- doi: 10.5808/GI.2012.10.2.106
Pulse rate is known to be related to diverse phenotypes, such as cardiovascular diseases, lifespan, arrhythmia, hypertension, lipids, diabetes, and menopause. We have reported two genomewide significant genetic loci responsible... -
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- Performance Comparison of Two Gene Set Analysis Methods for Genome-wide Association Study Results: GSA-SNP vs i-GSEA4GWAS
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Kwon JS, Kim J, Nam D, Kim S
- KMID: 2166495
- Genomics Inform.
- 2012 Jun;10(2):123-127.
- doi: 10.5808/GI.2012.10.2.123
Gene set analysis (GSA) is useful in interpreting a genome-wide association study (GWAS) result in terms of biological mechanism. We compared the performance of two different GSA implementations that accept... -
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- Sample Size and Statistical Power Calculation in Genetic Association Studies
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Hong EP, Park JW
- KMID: 2166494
- Genomics Inform.
- 2012 Jun;10(2):117-122.
- doi: 10.5808/GI.2012.10.2.117
A sample size with sufficient statistical power is critical to the success of genetic association studies to detect causal genes of human complex diseases. Genome-wide association studies require much larger... -
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- Identifying Copy Number Variants under Selection in Geographically Structured Populations Based on F-statistics
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Song HH, Hu HJ, Seok IH, Chung YJ
- KMID: 2166489
- Genomics Inform.
- 2012 Jun;10(2):81-87.
- doi: 10.5808/GI.2012.10.2.81
Large-scale copy number variants (CNVs) in the human provide the raw material for delineating population differences, as natural selection may have affected at least some of the CNVs thus far... -
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- Effect of Genetic Predisposition on Blood Lipid Traits Using Cumulative Risk Assessment in the Korean Population
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Go MJ, Hwang JY, Kim DJ, Lee HJ, Jang HB, Park KH, Song J, Lee JY
- KMID: 2166491
- Genomics Inform.
- 2012 Jun;10(2):99-105.
- doi: 10.5808/GI.2012.10.2.99
Dyslipidemia, mainly characterized by high triglyceride (TG) and low high-density lipoprotein cholesterol (HDL-C) levels, is an important etiological factor in the development of cardiovascular disease (CVD). Considering the relationship between... -
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- Genetic Analysis of SCN5A in Korean Patients Associated with Atrioventricular Conduction Block
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Park HS, Kim YN, Lee YS, Jung BC, Lee SH, Shin DG, Cho Y, Bae MH, Han SM, Lee MH
- KMID: 2166493
- Genomics Inform.
- 2012 Jun;10(2):110-116.
- doi: 10.5808/GI.2012.10.2.110
Recent several studies have shown that the genetic variation of SCN5A is related with atrioventricular conduction block (AVB); no study has yet been published in Koreans. Therefore, to determine the... -
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- Interaction Effects of Lipoprotein Lipase Polymorphisms with Lifestyle on Lipid Levels in a Korean Population: A Cross-sectional Study
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Pyun JA, Kim S, Park K, Baik I, Cho NH, Koh I, Lee JY, Cho YS, Kim YJ, Go MJ, Shim E, Kwack K, Shin C
- KMID: 2166490
- Genomics Inform.
- 2012 Jun;10(2):88-98.
- doi: 10.5808/GI.2012.10.2.88
Lipoprotein lipase (LPL) plays an essential role in the regulation of high-density lipoprotein cholesterol (HDLC) and triglyceride levels, which have been closely associated with cardiovascular diseases. Genetic studies in European... -
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