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Characteristics in Molecular Vibrational Frequency Patterns between Agonists and Antagonists of Histamine Receptors

Oh SJ

To learn the differences between the structure-activity relationship and molecular vibration-activity relationship in the ligand-receptor interaction of the histamine receptor, 47 ligands of the histamine receptor were analyzed by structural...
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Performance Comparison of Two Gene Set Analysis Methods for Genome-wide Association Study Results: GSA-SNP vs i-GSEA4GWAS

Kwon JS, Kim J, Nam D, Kim S

Gene set analysis (GSA) is useful in interpreting a genome-wide association study (GWAS) result in terms of biological mechanism. We compared the performance of two different GSA implementations that accept...
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Sample Size and Statistical Power Calculation in Genetic Association Studies

Hong EP, Park JW

A sample size with sufficient statistical power is critical to the success of genetic association studies to detect causal genes of human complex diseases. Genome-wide association studies require much larger...
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Genetic Analysis of SCN5A in Korean Patients Associated with Atrioventricular Conduction Block

Park HS, Kim YN, Lee YS, Jung BC, Lee SH, Shin DG, Cho Y, Bae MH, Han SM, Lee MH

Recent several studies have shown that the genetic variation of SCN5A is related with atrioventricular conduction block (AVB); no study has yet been published in Koreans. Therefore, to determine the...
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Replication of the Association of the 6q22.31c Locus near GJA1 with Pulse Rate in the Korean Population

Kim NH, Kim YJ, Oh JH, Cho YS

Pulse rate is known to be related to diverse phenotypes, such as cardiovascular diseases, lifespan, arrhythmia, hypertension, lipids, diabetes, and menopause. We have reported two genomewide significant genetic loci responsible...
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Effect of Genetic Predisposition on Blood Lipid Traits Using Cumulative Risk Assessment in the Korean Population

Go MJ, Hwang JY, Kim DJ, Lee HJ, Jang HB, Park KH, Song J, Lee JY

Dyslipidemia, mainly characterized by high triglyceride (TG) and low high-density lipoprotein cholesterol (HDL-C) levels, is an important etiological factor in the development of cardiovascular disease (CVD). Considering the relationship between...
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Interaction Effects of Lipoprotein Lipase Polymorphisms with Lifestyle on Lipid Levels in a Korean Population: A Cross-sectional Study

Pyun JA, Kim S, Park K, Baik I, Cho NH, Koh I, Lee JY, Cho YS, Kim YJ, Go MJ, Shim E, Kwack K, Shin C

Lipoprotein lipase (LPL) plays an essential role in the regulation of high-density lipoprotein cholesterol (HDLC) and triglyceride levels, which have been closely associated with cardiovascular diseases. Genetic studies in European...
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Identifying Copy Number Variants under Selection in Geographically Structured Populations Based on F-statistics

Song HH, Hu HJ, Seok IH, Chung YJ

Large-scale copy number variants (CNVs) in the human provide the raw material for delineating population differences, as natural selection may have affected at least some of the CNVs thus far...
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Alternative Splicing and Its Impact as a Cancer Diagnostic Marker

Kim YJ, Kim HS

Most genes are processed by alternative splicing for gene expression, resulting in the complexity of the transcriptome in eukaryotes. It allows a limited number of genes to encode various proteins...
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Perspectives of Integrative Cancer Genomics in Next Generation Sequencing Era

Kwon SM, Cho H, Choi JH, Jee BA, Jo Y, Woo HG

The explosive development of genomics technologies including microarrays and next generation sequencing (NGS) has provided comprehensive maps of cancer genomes, including the expression of mRNAs and microRNAs, DNA copy numbers,...
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