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A Program for Efficient Phasing of Three-Generation Trio SNP Genotype Data

Song S, Kim S

  • KMID: 1806241
  • Genomics Inform.
  • 2011 Sep;9(3):138-141.
Here, we report a computer program written in Python, which phases SNP genotypes and infers inherited deletions based on the pattern of Mendelian inheritance within a trio pedigree. When tiered...
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A Visualization Tool for Computational Analysis of DNA Methylation Level Using Bisulfite Sequencing Data

Tae H

  • KMID: 1806240
  • Genomics Inform.
  • 2011 Sep;9(3):136-137.
Methylation of cytosine is a post-synthesis modification that does not affect the primary DNA sequence but greatly influences gene expression level and phenotypes of an organism. As high-throughput sequencing of...
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Implementation of a Particle Swarm Optimization-based Classification Algorithm for Analyzing DNA Chip Data

Han X, Lee M

  • KMID: 1806239
  • Genomics Inform.
  • 2011 Sep;9(3):134-135.
DNA chips are used for experiments on genes and provide useful information that could be further analyzed. Using the data extracted from the DNA chips to find useful patterns or...
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Optimized Internal Control and Gene Expression Analysis in Epstein-Barr Virus-Transformed Lymphoblastoid Cell Lines

Nam HY, Kim HR, Shim SM, Lee JE, Kim JW, Park HK, Han BG, Jeon JP

  • KMID: 1806238
  • Genomics Inform.
  • 2011 Sep;9(3):127-133.
The Epstein-Barr virus-transformed lymphoblastoid cell line (LCL) is one of the major genomic resources for human genetics and immunological studies. Use of LCLs is currently extended to pharmacogenetic studies to...
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Genome-wide Association Study Identified TIMP2 Genetic Variant with Susceptibility to Osteoarthritis

Keam B, Hwang JY, Go MJ, Heo JY, Park MS, Lee JY, Kim NH, Park M, Oh JH, Kim DH, Jeong JY, Lee JY, Han BG, Lee J

  • KMID: 1806237
  • Genomics Inform.
  • 2011 Sep;9(3):121-126.
Osteoarthritis (OA) is the most common degenerative joint disorder in the elderly population. To identify OA-associated genetic variants and candidate genes, we conducted a genome-wide association study (GWAS). A total...
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Association of an Anti-inflammatory Cytokine Gene IL4 Polymorphism with the Risk of Type 2 Diabetes Mellitus in Korean Populations

Go MJ, Min H, Lee JY, Kim SS, Kim Y

  • KMID: 1806236
  • Genomics Inform.
  • 2011 Sep;9(3):114-120.
Chronic inflammation has been implicated as one of the important etiological factors in insulin resistance and type 2 diabetes mellitus (T2DM). To investigate the role of anti-inflammatory cytokines in the...
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Differentially Expressed Genes by Inhibition of C-terminal Src Kinase by siRNA in Human Vascular Smooth Muscle Cells and Their Association with Blood Pressure

Hong KW, Shin YB, Kim K, Oh B

  • KMID: 1806235
  • Genomics Inform.
  • 2011 Sep;9(3):102-113.
C-terminal SRC kinase (CSK) is a ubiquitously expressed, cytosolic enzyme that phosphorylates and inactivates several SRC family protein tyrosine kinases. Recent genomewide association studies have implicated CSK in the regulation...
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The Hairless Gene: A Putative Navigator of Hair Follicle Development

Kim JK, Kim BK, Park JK, Choi JH, Kim Yoon S

  • KMID: 1806234
  • Genomics Inform.
  • 2011 Sep;9(3):93-101.
The Hairless (HR) gene regulates the expression of several target genes as a transcriptional corepressor of nuclear receptors. The hair follicle (HF), a small independent organ of the skin, resides...
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