- A Visualization Tool for Computational Analysis of DNA Methylation Level Using Bisulfite Sequencing Data
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Tae H
- KMID: 1806240
- Genomics Inform.
- 2011 Sep;9(3):136-137.
Methylation of cytosine is a post-synthesis modification that does not affect the primary DNA sequence but greatly influences gene expression level and phenotypes of an organism. As high-throughput sequencing of... -
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- A Program for Efficient Phasing of Three-Generation Trio SNP Genotype Data
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Song S, Kim S
- KMID: 1806241
- Genomics Inform.
- 2011 Sep;9(3):138-141.
Here, we report a computer program written in Python, which phases SNP genotypes and infers inherited deletions based on the pattern of Mendelian inheritance within a trio pedigree. When tiered... -
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- Implementation of a Particle Swarm Optimization-based Classification Algorithm for Analyzing DNA Chip Data
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Han X, Lee M
- KMID: 1806239
- Genomics Inform.
- 2011 Sep;9(3):134-135.
DNA chips are used for experiments on genes and provide useful information that could be further analyzed. Using the data extracted from the DNA chips to find useful patterns or... -
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- The Hairless Gene: A Putative Navigator of Hair Follicle Development
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Kim JK, Kim BK, Park JK, Choi JH, Kim Yoon S
- KMID: 1806234
- Genomics Inform.
- 2011 Sep;9(3):93-101.
The Hairless (HR) gene regulates the expression of several target genes as a transcriptional corepressor of nuclear receptors. The hair follicle (HF), a small independent organ of the skin, resides... -
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- Optimized Internal Control and Gene Expression Analysis in Epstein-Barr Virus-Transformed Lymphoblastoid Cell Lines
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Nam HY, Kim HR, Shim SM, Lee JE, Kim JW, Park HK, Han BG, Jeon JP
- KMID: 1806238
- Genomics Inform.
- 2011 Sep;9(3):127-133.
The Epstein-Barr virus-transformed lymphoblastoid cell line (LCL) is one of the major genomic resources for human genetics and immunological studies. Use of LCLs is currently extended to pharmacogenetic studies to... -
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- Genome-wide Association Study Identified TIMP2 Genetic Variant with Susceptibility to Osteoarthritis
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Keam B, Hwang JY, Go MJ, Heo JY, Park MS, Lee JY, Kim NH, Park M, Oh JH, Kim DH, Jeong JY, Lee JY, Han BG, Lee J
- KMID: 1806237
- Genomics Inform.
- 2011 Sep;9(3):121-126.
Osteoarthritis (OA) is the most common degenerative joint disorder in the elderly population. To identify OA-associated genetic variants and candidate genes, we conducted a genome-wide association study (GWAS). A total... -
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- Association of an Anti-inflammatory Cytokine Gene IL4 Polymorphism with the Risk of Type 2 Diabetes Mellitus in Korean Populations
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Go MJ, Min H, Lee JY, Kim SS, Kim Y
- KMID: 1806236
- Genomics Inform.
- 2011 Sep;9(3):114-120.
Chronic inflammation has been implicated as one of the important etiological factors in insulin resistance and type 2 diabetes mellitus (T2DM). To investigate the role of anti-inflammatory cytokines in the... -
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- Differentially Expressed Genes by Inhibition of C-terminal Src Kinase by siRNA in Human Vascular Smooth Muscle Cells and Their Association with Blood Pressure
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Hong KW, Shin YB, Kim K, Oh B
- KMID: 1806235
- Genomics Inform.
- 2011 Sep;9(3):102-113.
C-terminal SRC kinase (CSK) is a ubiquitously expressed, cytosolic enzyme that phosphorylates and inactivates several SRC family protein tyrosine kinases. Recent genomewide association studies have implicated CSK in the regulation... -
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