- Genomic Instability in Colorectal Cancer; from Bench to Bed
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Lee KY
- KMID: 2334430
- J Korean Soc Coloproctol.
- 2009 Apr;25(2):129-138.
Colorectal cancer is a disease developed by the accumulation of genomic alteration. Two genomic instability pathways, chromosomal instability pathway and microsatellite instability pathway, are known as the main pathways of... -
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- Genome Architecture and Its Roles in Human Copy Number Variation
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Chen L, Zhou W, Zhang L, Zhang F
- KMID: 2391488
- Genomics Inform.
- 2014 Dec;12(4):136-144.
- doi: 10.5808/GI.2014.12.4.136
Besides single-nucleotide variants in the human genome, large-scale genomic variants, such as copy number variations (CNVs), are being increasingly discovered as a genetic source of human diversity and the pathogenic... -
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- Understanding of molecular pathogenesis and genetic markers in colorectal cancer
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Kim YH
- KMID: 2259110
- Korean J Med.
- 2010 Aug;79(2):113-118.
Colorectal cancers results from the progressive accumulation of genetic and epigenetic alterations that lead to cellular transformation and tumor progression. Genomic instability, including chromosomal translocations and microsatellite instability, plays a... -
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- Mechanism of Genomic Instability and Its Clinical Applications
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Lee SH
- KMID: 2334315
- J Korean Soc Coloproctol.
- 2004 Feb;20(1):64-73.
Multiple genetic alterations are common prerequisite for carcinogenesis including colorectal cancers (CRCs). Recently, mutations within microsatellites have been described as a result of defective DNA mismatch repair (MMR) mechanisms, resulting... -
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- Analysis of the mitochondrial D-loop sequence in a patient with thyroid Hurthle cell carcinoma and sacral bone metastasis
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Bai YS, Kim SY, Lee JH, Lee YH, Kim JM, Jo YS, Ro HK
- KMID: 2258114
- Korean J Med.
- 2009 Aug;77(Suppl 1):S109-S115.
Hurthle cell carcinoma, an oncocytic variant of follicular thyroid carcinoma, has a higher malignancy potential than well differentiated thyroid carcinomas. It has a tendency to metastasize easily to the lungs... -
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- Epigenetic Alterations and Loss of Imprinting in Colorectal Cancer
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Kim JW
- KMID: 2101396
- J Korean Soc Coloproctol.
- 2005 Jun;21(3):181-190.
Two forms of genomic instability have been described in colorectal cancer: chromosomal (CIN) and microsatellite instability (MIN). Colorectal cancer has been considered to progress through one of these two major... -
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- Sec13 induces genomic instability in U2OS cells
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Sihn CR, Suh EJ, Lee KH, Kim SH
- KMID: 1056239
- Exp Mol Med.
- 2005 Jun;37(3):255-260.
Sec13p has been known as an endoplasmic reticulum-Golgi transport protein. Recently, it has also been shown to be required for the formation of septation in the fission yeast Schizosaccharomyces pombe.... -
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- Structural Variation of Alu Element and Human Disease
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Kim S, Cho CS, Han K, Lee J
- KMID: 2353657
- Genomics Inform.
- 2016 Sep;14(3):70-77.
- doi: 10.5808/GI.2016.14.3.70
Transposable elements are one of major sources to cause genomic instability through various mechanisms including de novo insertion, insertion-mediated genomic deletion, and recombination-associated genomic deletion. Among them is Alu element... -
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- Genetic and epigenetic alterations of colorectal cancer
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Hong SN
- KMID: 2417644
- Intest Res.
- 2018 Jul;16(3):327-337.
- doi: 10.5217/ir.2018.16.3.327
Colorectal cancer (CRC) arise from multi-step carcinogenesis due to genetic mutations and epigenetic modifications of human genome. Genetic mutations and epigenetic modifications were originally established as 2 independent mechanisms contributing... -
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- Chromothripsis Identified by Copy Number Profiling in a Case of Plasma Cell Leukaemia
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Sohn MJ, Mun YC, Seong CM, Chung WS, Huh J
- KMID: 2200447
- J Lab Med Qual Assur.
- 2014 Jun;36(2):107-112.
A genomic instability called chromothripsis occurs as a single catastrophic event, generating massive complex genomic rearrangement with a possible characteristic pattern of copy number oscillations. Here, we report a case... -
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- DNA damage to human genetic disorders with neurodevelopmental defects
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Lee Y, Choi I, Kim J, Kim K
- KMID: 2327696
- J Genet Med.
- 2016 Jun;13(1):1-13.
- doi: 10.5734/JGM.2016.13.1.1
Although some mutations are beneficial and are the driving force behind evolution, it is important to maintain DNA integrity and stability because it contains genetic information. However, in the oxygen-rich... -
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- Interplay between Epigenetics and Genetics in Cancer
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Choi JD, Lee JS
- KMID: 2166498
- Genomics Inform.
- 2013 Dec;11(4):164-173.
- doi: 10.5808/GI.2013.11.4.164
Genomic instability, which occurs through both genetic mechanisms (underlying inheritable phenotypic variations caused by DNA sequence-dependent alterations, such as mutation, deletion, insertion, inversion, translocation, and chromosomal aneuploidy) and epigenomic aberrations... -
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- Analysis of Chromosomal Aberrations in Thyroid Papillary Carcinomas Using Comparative Genomic Hybridization (CGH)
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Kim JY, Kim HS, Park SY, Shin YR, Go YM, Kim HK, Lee DW, Chung SM
- KMID: 2276517
- Korean J Otolaryngol-Head Neck Surg.
- 2005 Nov;48(11):1369-1376.
BACKGROUND AND OBJECTIVES: Cancer of the thyroid is the sixth common cancer in Korea, and fourth common among the Korean women, in particular. Aming the prevalent carcinomas of thyroid, the... -
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- Non-homologous End Joining Inhibitor SCR-7 to Exacerbate Low-dose Doxorubicin Cytotoxicity in HeLa Cells
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Kumar A, Bhatkar D, Jahagirdar D, Sharma NK
- KMID: 2375548
- J Cancer Prev.
- 2017 Mar;22(1):47-54.
- doi: 10.15430/JCP.2017.22.1.47
Among the genotoxic drug regimens, doxorubicin (DOX) is known for its high-dose side effects in several carcinomas, including cervical cancer. This study reports on testing the combined use of a... -
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- Kidneys with bad ends
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Suh D
- KMID: 2322081
- J Korean Soc Pediatr Nephrol.
- 2008 Apr;12(1):11-22.
Telomeres consist of tandem guanine-thymine(G-T) repeats in most eukaryotic chromosomes. Human telomeres are predominantly linear, double stranded DNA as they ended in 30-200 nucleotides(bases,b) 3'-overhangs. In DNA replication, removal of... -
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- Identification of Target Genes in the Endometrial Carcinomas with Microsatellite Mutator Phenotype
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You KT, Kim H, Park TK, Sohn IS, Lee JY, Jang DW, Yang WG, Kim SN
- KMID: 2272602
- Korean J Obstet Gynecol.
- 2005 May;48(5):1229-1240.
OBJECTIVE: Recent molecular genetic studies have revealed that two major types of genomic instabilities, chromosomal instability and microsatellite instability (MSI), exist in the endometrial carcinomas. Tumors with microsatellite mutator phenotype... -
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- Genetic Instability and Microsatellite Alterations of Chromosome 5, 8, 13, 17 in Hepatocellular Carcinoma
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Lee KB, Cho SJ, Choi SY, Kim YC, Won NH, Suh SO
- KMID: 2095998
- J Korean Surg Soc.
- 2002 Sep;63(3):220-226.
PURPOSE: Neoplastic development is a multistep process that involves the accumulation of genetic alterations in proto- oncogenes, DNA repair genes, and tumor suppressor genes. Molecular studies in carcinoma have shown... -
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- Chromosomal Aberrations in Korean Hepatocellular Carcinomas
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Park HK, Choi D, Kim HJ, Lee KG, Cho YH, Lee KS
- KMID: 2244315
- Korean J Hepatobiliary Pancreat Surg.
- 2002 Jun;6(1):12-19.
BACKGROUND/AIMS: The pattern of chromosomal gains and losses in HCC with hepatitis B in Korean patients is very complex and involves virtually every site in the genome. This study was... -
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- Gnomic Instability of Microsatellite in Renal Cell Carcinoma
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Cho JH, Kwon TG, Gil YT, Park YK, Jung OB, Kim JW
- KMID: 2292288
- Korean J Urol.
- 2001 Aug;42(8):788-794.
PURPOSE: Genomic instability of microsatellite in patients with defects in the mismatch repair system of DNA resulting in replication error (RER) has a high risk of accumulating mutations in oncogene... -
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- Significance of Cellular Senescence in Aging and Cancer
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Grimes A, Chandra SB
- KMID: 1972671
- Cancer Res Treat.
- 2009 Dec;41(4):187-195.
Cellular senescence is a mechanism that induces an irreversible growth arrest in all somatic cells. Senescent cells are metabolically active but lack the capacity to replicate. Evolutionary theories suggest that... -
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