- Genistein Supplementation Inhibits Atherosclerosis with Stabilization of the Lesions in Hypercholesterolemic Rabbits
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Lee CS, Kwon SJ, Na SY, Lim SP, Lee JH
- KMID: 1733504
- J Korean Med Sci.
- 2004 Oct;19(5):656-661.
- doi: 10.3346/jkms.2004.19.5.656
The effect of genistein on aortic atherosclerosis was studied by immunohistochemistry with RAM-11 and HHF-35 antibodies and western blotting for matrix metalloproteinase-3 (MMP-3) in New Zealand White rabbits. After provocation... -
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- The Synergistic Apoptotic Interaction of Indole-3-Carbinol and Genistein with TRAIL on Endometrial Cancer Cells
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Parajuli B, Shin SJ, Kwon SH, Cha SD, Lee HG, Bae I, Cho CH
- KMID: 1786959
- J Korean Med Sci.
- 2013 Apr;28(4):527-533.
- doi: 10.3346/jkms.2013.28.4.527
Induction of apoptosis in target cells is a key mechanism by which chemotherapy promotes cell killing. The purpose of this study was to determine whether Indole-3-Carbinol (I3C) and Genistein in... -
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- Genistein activates endothelial nitric oxide synthase in broiler pulmonary arterial endothelial cells by an Akt-dependent mechanism
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Yang Y, Nie W, Yuan J, Zhang B, Wang Z, Wu Z, Guo Y
- KMID: 994400
- Exp Mol Med.
- 2010 Nov;42(11):768-776.
- doi: 10.3858/emm.2010.42.11.078
Deregulation of endothelial nitric oxide synthase (eNOS) plays an important role in the development of multiple cardiovascular diseases. Our recent study demonstrated that genistein supplementation attenuates pulmonary arterial hypertension in... -
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- A high concentration of genistein down-regulates activin A, Smad3 and other TGF-beta pathway genes in human uterine leiomyoma cells
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Di X, Andrews DM, Tucker CJ, Yu L, Moore AB, Zheng X, Castro L, Hermon T, Xiao H, Dixon D
- KMID: 1365905
- Exp Mol Med.
- 2012 Apr;44(4):281-292.
- doi: 10.3858/emm.2012.44.4.024
Previously, we found that high doses of genistein show an inhibitory effect on uterine leiomyoma (UtLM) cell proliferation. In this study, using microarray analysis and Ingenuity Pathways Analysis(TM), we identified... -
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- Exposure to genistein does not adversely affect the reproductive system in adult male mice adapted to a soy-based commercial diet
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Lee BJ, Kang JK, Jung EY, Yun YW, Baek IJ, Yon JM, Lee YB, Sohn HS, Lee JY, Kim KS, Nam SY
- KMID: 1099836
- J Vet Sci.
- 2004 Sep;5(3):227-234.
Genistein, a soybean-originated isoflavone, is widely consumed by humans for putative beneficial health effects but its estrogenic activity may affect adversely the development of male reproductive system. Five-week-old ICR mice... -
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