- Bcl-2 Expression in Korean Fetal Lungs
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Yoo YB
- KMID: 1566748
- Korean J Anat.
- 2004 Feb;37(1):1-8.
Apoptosis plays an important role in the morphogenesis and the function establishment of organs during embryonic development. Many reports have suggested apoptosis-related genes were ongenes, tumor suppressor genes, growthregulating factors.... -
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- Correlation of bcl-2 and p53 Expressions in Urinary Bladder Tumor
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Lee G, Kim HJ, Lee MC
- KMID: 2290345
- Korean J Urol.
- 1999 Jun;40(6):703-708.
PURPOSE: Alteration of p53 tumor suppressor genes is most frequently identified in human neoplasms, including urinary bladder tumor. The overexpression of the bcl-2 gene has been correlated with poor prognosis... -
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- p53 and Bcl-2 Expression and Apoptosis in Human Brain Tumors
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Yi HJ, Kim CH, Bak KH, Kim JM, Ko Y, Oh SJ
- KMID: 2339676
- J Korean Neurosurg Soc.
- 2002 Apr;31(4):357-363.
OBJECTIVE: In this preliminary report, the authors investigated whether apoptosis is affected by p53 and/or Bcl-2 in the surgical specimens of the human brain tumors. METHODS: During the period from July... -
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- The Effect of Mycolactone on the Expression of Bcl-2 Family Genes in Hep 3B Hepatoma Cells
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Lee TJ, Lee JS, Choi JE, Bae JJ, Lee TY
- KMID: 1572912
- J Bacteriol Virol.
- 2002 Mar;32(1):55-62.
Mycolactone is a recently reported lipid toxin of Mycobacterium ulcerans that causes Buruli ulcer, a severe human skin disease. However, the mechanism of cell death by mycolactone is still unclear.... -
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- Running Title: Apoptotic Effect of Mycolactone in SCC15 Cells
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Kim JW, Song JC, Lee HK, Lee TY
- KMID: 1961184
- J Korean Assoc Oral Maxillofac Surg.
- 2001 Dec;27(6):511-518.
The effect of mycolactone, a recently reported apoptosis-inducing factor, was investigated in SCC15 oral squamous cell carcinoma (OSCC) cell line. Mycolactone rapidly induced cell death in OSCC cells in 2days,... -
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- Expression of bcl-2 and p53 Protein in Primary Gastric Lymphomas
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Cho YR, Kang YN, Lee SS, Song HS, Sohn SS, Kim DS
- KMID: 2011621
- Korean J Pathol.
- 1998 Nov;32(11):978-984.
The bcl-2 gene is a proto-oncogene which extends cell survival by blocking apoptosis. Bcl-2 expression has been detected in many types of nodal and MALT lymphoma. The p53 gene is... -
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- The Expression of bcl-2 Oncoprotein in Colorectal Polyps and Cancers
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Chang SK, Moon C, Kim JW, Heo CH, Kim HJ, Do JH, Joe JH
- KMID: 2240642
- Korean J Gastroenterol.
- 1998 Feb;31(2):175-183.
Background/Aims,, The bcl-2 gene is an oncogene that inhibits programmed cell death or apoptosis. Overexpression of bcl-2 probably plays a role in colorectal carcinogenesis. The aim of our study was... -
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- BCL-2 and BAX Expression in Normal Human Endometrium
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Hong SO, Lee BS, Yang WI, Lee JS, Cha DH, Cho YS, Kim JY, Park KH, Cho DJ, Song CH
- KMID: 2085139
- Korean J Fertil Steril.
- 2000 Sep;27(3):245-251.
OBJECTIVE: To investigate the distribution of BCL-2, BAX proteins and DNA fragmented cells in the normal human endometrium during at each menstrual cycle in order to find out whether apoptosis... -
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- Expression of Bcl-2 and Bax in cis-Diamminedichloroplatinum (II)-Resistant Bladder Cancer Cell Lines
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Song C, Kang TJ, You DS, Hong JH, Ahn HJ
- KMID: 2293492
- Korean J Urol.
- 2004 May;45(5):472-477.
PURPOSE: Development of drug resistance has been the major obstacle in cis-Diamminedichloroplatinum (II) (cisplatin)-based combination chemotherapy in the treatment of advanced bladder cancer for which a variety of mechanisms has... -
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- Immunohistochemical Study of p53 Gene Protein and bcl-2 Gene Protein Expression in Gastric Adenocarcinoma
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Yang JP, Cha SJ, Park SJ, Lim HM, Park SI, Park US
- KMID: 2206324
- J Korean Surg Soc.
- 1998 Mar;54(3):353-362.
The p53 oncoprotein, a product of the tumor suppressor gene encoded on the short arm of chromosome 17, has been noted in a number of human tumors as a tumor... -
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- p53 and bcl-2 Gene Expression in Gastational Trophoblastic Disease
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Park NH, Roh JW, Kim JW, Song YS, Park IA, Kang SB, Lee HP
- KMID: 2175201
- J Korean Cancer Assoc.
- 1999 Jun;31(3):582-589.
PURPOSE: p53 and bcl-2 expressions are known as important cell survival factors and their levels of expression are related with patients prognosis in various human malignancies. But there are few... -
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- Apoptosis and the Expression of p53, Bcl-2 in Very Delayed Focal Cerebral Infarction and Penumbra
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Chung C, Park SW, Kim YB, Hwang SN, Kim MK, Kwon JT, Min BK, Suk JS, Choi DY
- KMID: 2188192
- J Korean Neurosurg Soc.
- 1998 Jul;27(7):855-864.
Apoptosis is a physiological or programmed cell death process controlled by genes, which is thought to be one of the main mechanisms of cell death in cerebral infarction. The apoptosis... -
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- The Effects of Vero Cell Co-culture on the Expression of Bax and Bcl-2 Genes in the Mouse Embryo Development
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Yoon TK, Chung KN, Kim YB
- KMID: 2272707
- Korean J Obstet Gynecol.
- 2005 Oct;48(10):2377-2385.
OBJECTIVE: To investigate the effects of Vero cell co-culture on the development of mouse embryo in vitro and the expression of bax and bcl-2 genes in the mouse embryo. METHODS:... -
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- Anticancer Effect and Apoptosis of All-trans-retinoic Acid on the Human Ovarian Epithelial Carcinoma Cell Lines
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Han JY, Jung WH, Kim TS
- KMID: 1725666
- Korean J Pathol.
- 2000 Mar;34(3):225-234.
Ovarian carcinoma is a serious disease in women. Some reports revealed all-trans-retinoic acid (tRA) inhibited the proliferation of ovarian carcinoma cell lines and induced apoptosis. The aim of this study... -
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- Bcl-2 Expression in the Developing Korean Fetal Esophagus
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Yoo YB
- KMID: 2030770
- Korean J Anat.
- 2005 Feb;38(1):39-47.
This study was intended to obtain the basic data in order to understand the role of the apoptosis-suppressing gene, bcl-2, in the esophageal development. Immunohistochemistry for bcl-2 was performed using... -
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- Correlation between Cyclin D1 , p53 , Bcl-2 Protein Expression and Prognosis in Primary , Resected Stage IIIA Non-Small Cell Lung Cancer (NSCLC)
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Chung KY, Yang WI
- KMID: 2288954
- Korean J Thorac Cardiovasc Surg.
- 1998 Dec;31(12):1200-1205.
BACKGROUND: Lung cancer formation is a multistage process involving activation of protooncogene and inactivation of tumor suppressor genes. We evaluate the significance of cyclin D1, p53, bcl-2 gene mutations in... -
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- Therapeutic Modulation of Apoptosis: Targeting the BCL-2 Family at the Interface of the Mitochondrial Membrane
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Nemec KN, Khaled AR
- KMID: 2158185
- Yonsei Med J.
- 2008 Oct;49(5):689-697.
- doi: 10.3349/ymj.2008.49.5.689
A vast portion of human disease results when the process of apoptosis is defective. Disorders resulting from inappropriate cell death range from autoimmune and neurodegenerative conditions to heart disease. Conversely,... -
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- Induction of Apoptosis of Cancer Cells by Inhibition of Bcl-2 Expression
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Yi HK, Han MH, Cho SC, Kim JS, Hwang YH
- KMID: 2329167
- J Korean Cancer Assoc.
- 1999 Aug;31(4):716-727.
PURPOSE: High levels and aberrant patterns of Bcl-2 gene expression have been reported in a variety of human cancers, including prostate, colorectal, lung and gastric cancers, neuroblastoma, non-Hodgkins lymphoma, and... -
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- Protective Effect of Probucol against Adriamycin-Induced Apoptosis in Cultured Rat Cardiac Myocytes
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Lee SJ, Lee DS, Jung YW
- KMID: 2207532
- J Korean Pediatr Soc.
- 2000 Jun;43(6):746-754.
PURPOSE: In adriamycin(ADR)-induced cardiomyopathy, several different mechanisms are suggested. However, little information is available regarding the role of apoptosis. In the present study, we examined the induction of apoptosis on... -
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- Antidiabetic Drug Metformin Protects Neuronal Cells against Quinolinic Acid-Induced Excitotoxicity by Decreasing Intracellular Calcium
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Jang S, Park SH
- KMID: 2458581
- Chonnam Med J.
- 2018 Jan;54(1):24-30.
- doi: 10.4068/cmj.2018.54.1.24
The antidiabetic drug metformin has been found to have beneficial effects in various neurological disorders; however, the molecular mechanisms underlying these effects remain unclear. Here we report that metformin protects... -
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