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Oxytocin produces thermal analgesia via vasopressin-1a receptor by modulating TRPV1 and potassium conductance in the dorsal root ganglion neurons

Han RT, Kim HB, Kim YB, Choi K, Park GY, Lee PR, Lee J, Kim HY, Park CK, Kang Y, Oh SB, Na HS

Recent studies have provided several lines of evidence that peripheral administration of oxytocin induces analgesia in human and rodents. However, the exact underlying mechanism of analgesia still remains elusive. In...
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Inhibiting Vascular Endothelial Growth Factor in Injured Intervertebral Discs Attenuates Pain-Related Neuropeptide Expression in Dorsal Root Ganglia in Rats

Sato J, Inage K, Miyagi M, Sakuma Y, Yamauchi K, Koda M, Furuya T, Nakamura J, Suzuki M, Kubota G, Oikawa Y, Sainoh T, Fujimoto K, Shiga Y, Abe K, Kanamoto H, Inoue M, Kinoshita , Norimoto M, Umimura T, Takahashi , Ohtori S, Orita S

STUDY DESIGN: An experimental animal study. PURPOSE: To evaluate effects of anti-vascular endothelial growth factor (VEGF) on the content and distribution of the calcitonin gene-related peptide (CGRP) in the dorsal ganglia...
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Protein Kinase C Mediates the Corticosterone-induced Sensitization of Dorsal Root Ganglion Neurons Innervating the Rat Stomach

Li M, Xue L, Zhu HY, Wang H, Xu X, Zhang PA, Wu G, Xu GY

  • KMID: 2387838
  • J Neurogastroenterol Motil.
  • 2017 Jul;23(3):464-476.
  • doi: 10.5056/jnm16161
BACKGROUND/AIMS: Gastric hypersensitivity contributes to abdominal pain in patients with functional dyspepsia. Recent studies showed that hormones induced by stress are correlated with visceral hypersensitivity. However, the precise mechanisms underlying...
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Enhanced Expression of TREK-1 Is Related with Chronic Constriction Injury of Neuropathic Pain Mouse Model in Dorsal Root Ganglion

Han HJ, Lee SW, Kim GT, Kim EJ, Kwon B, Kang D, Kim HJ, Seo KS

Neuropathic pain is a complex state showing increased pain response with dysfunctional inhibitory neurotransmission. The TREK family, one of the two pore domain K+ (K2P) channel subgroups were focused among...
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Evaluation of Behavior and Expression of Receptor Activator of Nuclear Factor-Kappa B Ligand in Dorsal Root Ganglia after Sciatic Nerve Compression and Application of Nucleus Pulposus in Rats

Matsuyama , Sakuma Y, Suzuki M, Orita S, Yamauchi K, Inoue G, Aoki Y, Ishikawa T, Miyagi M, Kamoda H, Kubota G, Oikawa Y, Inage K, Sainoh T, Sato J, Nakamura J, Toyone T, Takahashi , Ohtori S

STUDY DESIGN: Experimental animal study. PURPOSE: To evaluate pain-related behavior and changes in nuclear factor-kappa B (NF-kB), receptor activator of NF-kB (RANK), and ligand (RANKL) in dorsal root ganglia (DRG) after...
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Identification of Differentially Expressed Genes by Gabapentin in Cultured Dorsal Root Ganglion in a Rat Neuropathic Pain Model

Heo JH, Lee SH, Chang KH, Han EH, Lee SG, Choi DW, Kim SW

  • KMID: 1502514
  • Biomol Ther.
  • 2013 Mar;21(2):126-131.
Neuropathic pain is a chronic pain disorder caused by nervous system lesions as a direct consequence of a lesion or by disease of the portions of the nervous system that...
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Pulsed Radiofrequency of Lumbar Dorsal Root Ganglia for Treatment of Chronic Inguinal Herniorrhaphy Pain: A case report

Kang SH, Han HJ, Kim WY, Kim DY, Moon DE

Inguinal hernia repair can result in paresthesia and/or pain in the inguinal region. Pharmacological and surgical management often yield inconsistent results associated with considerable risks and side effects. Radiofrequency thermocoagulation...
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Expression Profile of Tumor Endothelial Marker 7 and a Putative Ligand in the Rat Spinal Cord and Dorsal Root Ganglion

Wang L, Lee KY, Park HT, Kang DS

STUDY DESIGN: To analyze the expression profile of tumor endothelial marker 7 (TEM7) in the spinal cord and dorsal root ganglion (DRG). PURPOSE: To investigate the expression profile of TEM7...
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The Effect on Fos Expression in Rat Spinal Cord following Stimulation to Dorsal Root Ganglion by Pulsed Radiofrequency

Seo JH, Byeon WT, Kwon YB, Sim YJ

  • KMID: 2324592
  • J Korean Acad Rehabil Med.
  • 2007 Aug;31(4):387-393.
OBJECTIVE: To reconfirm the relationship between the Fos expression and the pulsed radiofrequency which very few articles have reported. METHOD: Thirty-four male Sprague-Dawely rats were enrolled: 8 for lumbar 3rd dorsal...
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Change in the Expression of p75 Neurotrophin Receptor and TRPV1 in the Spinal Cord and Dorsal Root Ganglion after an Injury to the Spinal Nerves in Rats

Cho JL, Kang CN, Kim TS, Park YS, Baik DJ, Hwang SJ

  • KMID: 2398743
  • J Korean Orthop Assoc.
  • 2006 Aug;41(4):711-720.
PURPOSE: To determine the relationship between change in the expression of the p75 neurotrophin receptor (NTR) and transient receptor potential vanilloid 1 (TRPV1) after a spinal nerve injury with time. MATERIALS...
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The most appropriate antimitotic treatment of Ara-C in schwann cell-enriched culture from dorsal root ganglia of new born rat

Kim SM, Jahng JW, Lee JH

  • KMID: 2190357
  • J Korean Assoc Oral Maxillofac Surg.
  • 2006 Feb;32(1):42-51.
Schwann cell, one of important components of peripheral nervous system, interact with neurons to mutually support the growth and replication of embryonal nerves and to maintain the different functions of...
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Alteration of Ionic Zinc Distribution in Rat Spinal Ganglion by Inflammatory Pain Stimulus: Autometallography

Lee B, Jun G, Kim YS, Lee B, Lee YI, Kim DJ, Jo SM

  • KMID: 2224492
  • Korean J Anat.
  • 2005 Dec;38(6):561-566.
This study was designed to investigate any correlation between the mechanism of pain development and changes of histochemically reactive zinc contents in the rat spinal ganglion following complete Freund's Adjuvant...
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Differential Expression of Somatostatin Receptor Subtype 2 in Dorsal Root Ganglia after Ischemic Injury in the Rat

Noh KC, Chung YK, Yoo JH, Jang WS, Lee JD, Won MH

  • KMID: 1901405
  • J Korean Orthop Assoc.
  • 2004 Dec;39(7):736-744.
PURPOSE: The somatostatin has been suggested to play a role in the transmission of neurotransmitters and the modulation of pain. Therefore, this study was carried out to investigate the spatial...
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Epidural Hyaluronic Acid in a Rat Model of Chronic Dorsal Root Ganglion Compression

Jeon YT, Hwang JW, Lim YJ, Kim YC, Lee SC

BACKGROUND: Hyaluronic acid (HA) is a naturally occurring polysaccharide that has been shown to be beneficial in various clinical settings, such as in opthalmic surgery or for intra-articular injections. This...
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The most appropriate antimitotic treatment of Ara-C in schwann cell-enriched culture from dorsal root ganglia of new born rat

Kim SM, Lee JH, Ahn KM, Kim NY, Sung MA, Hwang SJ, Kim JH, Jahng JW

  • KMID: 2190425
  • J Korean Assoc Oral Maxillofac Surg.
  • 2004 Apr;30(2):100-107.
Schwann cell, one of important components of peripheral nervous system, interact with neurons to mutually support the growth and replication of embryonal nerves and to maintain the different functions of...
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Immunoreactivity of Somatostatin Receptor Subtype 2 in Dorsal Root Ganglia in the Rat

Noh KC, Chung YK, Yoo JH, Park JS, Lee JD, Kang MC, Won MH, Kang TC, Park SK

  • KMID: 2106037
  • J Korean Orthop Assoc.
  • 2004 Feb;39(1):88-93.
PURPOSE: Somatostatin has been suggested to play a role in the transmission of neurotransmitters and in the modulation of pain. Of the different subtypes of somatostatin receptors 2, sstr2A and...
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Improved protocol for schwann cell isolation and proliferation from rat dorsal root ganglia in vitro

Kim SM, Lee JH, Kim NY, Ahn KM, Choi WJ, Choi SH, Cha MJ, Lee JY, Hwang SJ, Jahng JW, Myoung H, Choi JY, Seo BM, Choung PH, Kim MJ

  • KMID: 2118343
  • J Korean Assoc Maxillofac Plast Reconstr Surg.
  • 2003 Jul;25(4):265-272.
Schwann cells(SCs), an important component of the peripheral nervous system, interact with neurons to mutually support growth and replication for the peripheral nerve regeneration. Recently, adding SCs to the lumen...
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The Effect of Pulsed Radiofrequency Field Applied to Dorsal Root Ganglion

Kim DW, Koo MS, Lee SK, Lee JW, Shim JC, Key WY

  • KMID: 1947098
  • J Korean Pain Soc.
  • 2003 Jun;16(1):48-53.
BACKGROUND: With the use of L2 spinal nerve block, an improvement in the symptoms of patients with discogenic lower back pain has been reported. The clinical effect of pulsed radiofrequency...
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Changes of Electrophysiologic Properties of Dorsal Root Ganglion Cells in Peripheral Nerve-injured Rats

Chang SK, Chung SS, Leem JW, Eun JW, Yoon DM, Nam TS

  • KMID: 1947094
  • J Korean Pain Soc.
  • 2003 Jun;16(1):23-32.
BACKGROUND: The neuropathic pain induced by peripheral nerve injury has been shown to be spontaneous, hyperalgesia and allodynia. If the neuropathic pain is related to the sympathetic system, it is...
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Activation of Mitogen-Activated Protein Kinases in the Rat Dorsal Root Ganglia Following Peripheral Tissue Inflammation or Nerve Injuries

Bae JC, Lee HL, Lee KM, Hwang SH, Sohn SJ, Kim DS, Cho HJ

  • KMID: 1514946
  • Korean J Anat.
  • 2003 Jun;36(3):237-246.
The mitogen-activated protein kinase (MAPK) family has three members: the extracellular signal-regulated kinase (ERK), p38 MAPK and c-Jun N-terminal kinase (JNK). There is substantial evidence indicating that the MAPK cascade...
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