- A new member of alpha 1-adrenoceptor-coupled G alpha h (transglutaminase II) family in pig heart: purification and characterization
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Yoo SM, Jeong HS, Han KJ, Cho SH, Lee HS, Yun HY, Kwon NS, Baek KJ
- KMID: 754992
- Exp Mol Med.
- 1998 Jun;30(2):81-86.
We previously reported an identification of a 77-kDa GTP-binding protein that co-purified with the alpha 1-adrenoceptor following ternary complex formation. In the present paper, we report on the purification and characterization of... -
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- The proteins of synaptic vesicle membranes are affected during ageing of rat brain
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Lee SR, Kim AR, Kim JS, Kim JB, Lee JY, Lee YL, Choe M, Park JB
- KMID: 1457533
- Exp Mol Med.
- 2001 Dec;33(4):220-225.
Low molecular weight GTP-binding proteins are molecular switches that are believed to play pivotal roles in cell growth, differentiation, cytoskeletal organization, and vesicular trafficking. Rab proteins are key players in... -
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- Phosphorylation of 46-kappa Da protein of synaptic vesicle membranes is stimulated by GTP and Ca2+/calmodulin
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Kim AR, Choi WH, Lee SR, Kim JS, Jeon CY, Kim JI, Kim JB, Lee JY, Kim EG, Park JB
- KMID: 1121097
- Exp Mol Med.
- 2002 Dec;34(6):434-443.
The release of neurotransmitter is regulated in the processes of membrane docking and membrane fusion between synaptic vesicles and presynaptic plasma membranes. Synaptic vesicles contain a diverse set of... -
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- G protein signaling in the parasite Entamoeba histolytica
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Bosch DE, Siderovski DP
- KMID: 2154234
- Exp Mol Med.
- 2013 Mar;45(3):e15.
The parasite Entamoeba histolytica causes amebic colitis and systemic amebiasis. Among the known amebic factors contributing to pathogenesis are signaling pathways involving heterotrimeric and Ras superfamily G proteins. Here, we... -
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- Stimulatory heterotrimeric G protein augments gamma ray-induced apoptosis by up-regulation of Bak expression via CREB and AP-1 in H1299 human lung cancer cells
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Choi YJ, Kim SY, Oh JM, Juhnn YS
- KMID: 1119325
- Exp Mol Med.
- 2009 Aug;41(8):592-600.
- doi: 10.3858/emm.2009.41.8.065
Stimulatory heterotrimeric GTP-binding proteins (Gs protein) stimulate cAMP generation in response to various signals, and modulate various cellular phenomena such as proliferation and apoptosis. This study aimed to investigate the... -
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- Intrinsic Cellular Defenses against Virus Infection by Antiviral Type I Interferon
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Boo KH, Yang JS
- KMID: 1779600
- Yonsei Med J.
- 2010 Jan;51(1):9-17.
- doi: 10.3349/ymj.2010.51.1.9
Intrinsic cellular defenses are non-specific antiviral activities by recognizing pathogen-associated molecular patterns (PAMPs). Toll-like receptors (TLRs), one of the pathogen recognize receptor (PRR), sense various microbial ligands. Especially, TLR2, TLR3,... -
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- Cysteine carboxyl O-methylation of human placental 23 kDa protein
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Hong KM, Choi YB, Hong JH, Chang HS, Rhee KI, Park H, Paik MK
- KMID: 755024
- Exp Mol Med.
- 1999 Mar;31(1):30-35.
C-Terminal carboxyl methylation of a human placental 23 kDa protein catalyzed by membrane-associated methyltransferase has been investigated. The 23 kDa protein substrate methylated was partially purified by DEAE-Sephacel, hydroxyapatite and Sephadex G-100 gel... -
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- Wnt5a stimulates chemotactic migration and chemokine production in human neutrophils
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Jung YS, Lee HY, Kim SD, Park JS, Kim JK, Suh PG, Bae YS
- KMID: 2154246
- Exp Mol Med.
- 2013 Jun;45(6):e27.
Wnt5a is a ligand that activates the noncanonical Wnt signaling pathways (beta-catenin-independent pathways). Human neutrophils expressed several Wnt5a receptors, such as Frizzled 2, 5 and 8. Stimulation of human neutrophils... -
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- Nucleolus contains signal molecules that constitute membrane-nucleolus linked pathway
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Jeong JS, Kim IH, Lee HJ, Choi YC
- KMID: 755010
- Exp Mol Med.
- 1998 Dec;30(4):205-213.
Since there have been very few studies on nucleolar signaling, an attempt was made to establish nucleolar signal pathways which link the cell membrane to the nucleolus for the transfer... -
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- Ligation of CD40 receptor in human B lymphocytes triggers the 5-lipoxygenase pathway to produce reactive oxygen species and activate p38 MAPK
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Ha YJ, Seul HJ, Lee JR
- KMID: 1097267
- Exp Mol Med.
- 2011 Feb;43(2):101-110.
- doi: 10.3858/emm.2011.43.2.012
Previously, we reported that CD40-induced production of reactive oxygen species (ROS) by NADPH oxidase requires the TNF receptor-associated factor (TRAF) 3, as well as the activities of phosphatidylinositol 3-kinase (PI3K)... -
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- Increased expression of Galphaq protein in the heart of streptozotocin-induced diabetic rats
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Yang JM, Cho CH, Kong KA, Jang IS, Kim HW, Juhnn YS
- KMID: 1029924
- Exp Mol Med.
- 1999 Dec;31(4):179-184.
Heart disease is one of the major cause of death in diabetic patients, but the thogenesis of diabetic cardio-myopathy remains unclear. In this experiment, to sess the significance... -
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- Co-activation of Gi and Gq proteins exerts synergistic effect on human platelet aggregation through activation of phospholipase C and Ca2+ signalling pathways
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Shah BH, Siddiqui A, Qureshi KA, Khan M, Rafi S, Ujan VA, Yakoob MY, Rasheed H, Saeed SA
- KMID: 755026
- Exp Mol Med.
- 1999 Mar;31(1):42-46.
Our previous studies have shown that subthreshold concentrations of two platelet agonists exert synergistic effects on platelet aggregation. Here we studied the mechanism of synergistic interaction of 5-hydroxytryptamine (5-HT) and epinephrine mediated platelet... -
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- D4-GDI is cleaved by caspase-3 during daunorubicin-induced apoptosis in HL-60 cells
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Kwon KB, Park EK, Ryu DG, Park BH
- KMID: 1093595
- Exp Mol Med.
- 2002 Mar;34(1):32-37.
Daunorubicin, an anti-cancer drug, is known to induce apoptosis in HL-60 cells in a dose-dependent manner through the activation of caspase-3 (CPP32). Caspase-3 selective inhibitor, Ac-DEVD-CHO, prevented both the activation... -
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