- Preventing Metachronous Gastric Cancer after the Endoscopic Resection of Gastric Epithelial Neoplasia: Roles of Helicobacter pylori Eradication and Aspirin
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Watari J, Tomita T, Tozawa K, Oshima T, Fukui H, Miwa H
- KMID: 2500531
- Gut Liver.
- 2020 May;14(3):.
- doi: 10.5009/gnl19079
Whether Helicobacter pylori eradication actually reduces the risk of metachronous gastric cancer (MGC) development remains a controversial question. In this review, we addressed this topic by reviewing the results of... -
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- Role of Gut Microbiota-Gut Hormone Axis in the Pathophysiology of Functional Gastrointestinal Disorders
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Fukui H, Xu X, Miwa H
- KMID: 2417381
- J Neurogastroenterol Motil.
- 2018 Jul;24(3):367-386.
- doi: 10.5056/jnm18071
Gut microbiota exert a pivotal influence on various functions including gastrointestinal (GI) motility, metabolism, nutrition, immunity, and the neuroendocrine system in the host. These effects are mediated by not only... -
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- Spatial Allocation and Specification of Cardiomyocytes during Zebrafish Embryogenesis
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Fukui H, Chiba A, Miyazaki T, Takano H, Ishikawa H, Omori T, Mochiuzki
- KMID: 2377452
- Korean Circ J.
- 2017 Mar;47(2):160-167.
- doi: 10.4070/kcj.2016.0280
Incomplete development and severe malformation of the heart result in miscarriage of embryos because of its malfunction as a pump for circulation. During cardiogenesis, development of the heart is precisely... -
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- Leaky Gut and Gut-Liver Axis in Liver Cirrhosis: Clinical Studies Update
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Fukui H
- KMID: 2520119
- Gut Liver.
- 2021 Sep;15(5):666-676.
- doi: 10.5009/gnl20032
Portal blood flows into the liver containing the gut microbiome and its products such as endotoxin and bacterial DNA. The cirrhotic liver acts and detoxifies as the initial site of... -
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- Esophageal Sensation and Esophageal Hypersensitivity: Overview From Bench to Bedside
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Miwa H, Kondo T, Oshima T, Fukui H, Tomita T, Watari J
- KMID: 2204231
- J Neurogastroenterol Motil.
- 2010 Oct;16(4):353-362.
Noxious stimuli in the esophagus activate nociceptive receptors on esophageal mucosa, such as transient receptor potential, acid-sensing ion channel and the P2X family, a family of ligand-gated ion channels responsive... -
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- Prevalence and Self-recognition of Chronic Constipation: Results of an Internet Survey
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Tamura A, Tomita T, Oshima T, Toyoshima , Yamasaki T, Okugawa T, Kondo T, Kono T, Tozawa K, Ikehara H, Ohda Y, Fukui H, Watari J, Miwa H
- KMID: 2433461
- J Neurogastroenterol Motil.
- 2016 Oct;22(4):677-685.
- doi: 10.5056/jnm15187
BACKGROUND/AIMS: Although chronic constipation is a common symptom, to date no international consensus has been reached regarding its definition. The aims of this study were (1) to investigate defecation habits... -
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- Yokukansan Suppresses Gastric Hypersensitivity and Eosinophil-associated Microinflammation in Rats With Functional Dyspepsia
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Duan S, Imamura N, Kondo T, Kanda H, Kogure Y, Okugawa T, Fukushima M, Tomita T, Oshima T, Fukui H, Noguchi K, Dai Y, Miwa H
- KMID: 2528040
- J Neurogastroenterol Motil.
- 2022 Apr;28(2):255-264.
- doi: 10.5056/jnm21204
Background/Aims Herbal medicine is an important complementary therapy for functional dyspepsia (FD). However, its effect against gastric hypersensitivity in patients with FD has rarely been evaluated. Yokukansan (YKS), a traditional Japanese... -
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- Esophagography in Patients With Esophageal Achalasia Diagnosed With High-resolution Esophageal Manometry
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Yamasaki T, Tomita T, Mori S, Takimoto M, Tamura A, Hara K, Kondo T, Kono T, Tozawa K, Ohda Y, Oshima T, Fukui H, Watari J, Miwa H
- KMID: 2417384
- J Neurogastroenterol Motil.
- 2018 Jul;24(3):403-409.
- doi: 10.5056/jnm17147
BACKGROUND/AIMS: High-resolution esophageal manometry (HREM) is considered to be the gold standard for the diagnosis of achalasia. However, the Japan Esophageal Society recommends that esophagography is also accurate in either... -
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- Prevalence of Gastric Motility Disorders in Patients with Functional Dyspepsia
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Asano H, Tomita T, Nakamura K, Yamasaki T, Okugawa T, Kondo T, Kono T, Tozawa K, Ohda Y, Oshima T, Fukui H, Fukushima , Hirota S, Watari J, Miwa H
- KMID: 2387830
- J Neurogastroenterol Motil.
- 2017 Jul;23(3):392-399.
- doi: 10.5056/jnm16173
BACKGROUND/AIMS: Gastric motility abnormalities have been considered to be pathophysiological features of functional dyspepsia (FD) that are closely related to dyspepsia symptoms, especially postprandial distress syndrome (PDS). The aims of... -
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- Diarrhea-predominant Irritable Bowel Syndrome-like Symptoms in Patients With Quiescent Crohn’s Disease: Comprehensive Analysis of Clinical Features and Intestinal Environment Including the Gut Microbiome, Organic Acids, and Intestinal Permeability
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Tomita T, Fukui H, Morishita D, Maeda A, Makizaki Y, Tanaka Y, Ohno H, Oshima T, Miwa H
- KMID: 2537945
- J Neurogastroenterol Motil.
- 2023 Jan;29(1):102-112.
- doi: 10.5056/jnm22027
Background/Aims Diarrhea-predominant irritable bowel syndrome (IBS-D)-like symptoms frequently occur in patients with quiescent Crohn’s disease (CD). To investigate the factors underlying IBS-D-like symptoms in patients with quiescent CD, we performed a... -
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- Intravenous Corticotropin-releasing Hormone Administration Increases Esophageal Electrical Sensitivity in Healthy Individuals
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Yamasaki T, Tomita T, Takimoto M, Kondo T, Tozawa K, Ohda Y, Oshima T, Fukui H, Watari J, Miwa H
- KMID: 2395420
- J Neurogastroenterol Motil.
- 2017 Oct;23(4):526-532.
- doi: 10.5056/jnm17067
BACKGROUND/AIMS: When a person is experiencing stress, corticotropin-releasing hormone (CRH) can modulate gut physiologies, such as visceral sensation or gastrointestinal motility, and its intravenous administration mimics stress-induced physiological changes. However,... -
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- A Randomized Double-blind Placebo-controlled Trial on the Effect of Magnesium Oxide in Patients With Chronic Constipation
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Mori S, Tomita T, Fujimura K, Asano H, Ogawa T, Yamasaki T, Kondo T, Kono T, Tozawa K, Oshima T, Fukui H, Kimura T, Watari J, Miwa H
- KMID: 2460486
- J Neurogastroenterol Motil.
- 2019 Oct;25(4):563-575.
- doi: 10.5056/jnm18194
BACKGROUND/AIMS: Magnesium oxide (MgO) has been frequently used as a treatment for chronic constipation (CC) since the 1980s in Japan. The aim of this study is to evaluate its therapeutic... -
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- Prevalence of Irritable Bowel Syndrome–like Symptoms in Japanese Patients with Inactive Inflammatory Bowel Disease
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Tomita T, Kato Y, Takimoto M, Yamasaki T, Kondo T, Kono T, Tozawa K, Yokoyama Y, Ikehara H, Ohda Y, Oshima T, Fukui H, Tanaka S, Shima M, Watari J, Miwa H
- KMID: 2433459
- J Neurogastroenterol Motil.
- 2016 Oct;22(4):661-669.
- doi: 10.5056/jnm15160
BACKGROUND/AIMS: Few studies are available that have investigated the risk factors for overlapping irritable bowel syndrome (IBS)-like symptoms in patients with inactive inflammatory bowel disease (IBD). The present study has... -
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