- Anticonvulsant Effect of Flutamide in vitro Seizure Model
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Kim WJ, Lee SY, Lee BI
- KMID: 1480900
- J Korean Epilepsy Soc.
- 2008 Dec;12(2):92-95.
PURPOSE: Flutamide (4-nitro-3-t-trifluoromethyl-isobutyranilide) is an androgen-receptor antagonist with typical antiandrogenic effect, used to treat androgen-dependent disorders such as prostate cancer. However, some reports noted that flutamide has direct effects to... -
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- Incidence of Flutamide-induced Liver Toxicity in Patients with Prostate Cancer in Korea
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Chung BH, Hong SJ, Lee DH, Kang SJ, Mah SY
- KMID: 2290024
- Korean J Urol.
- 1998 Jan;39(1):41-44.
PURPOSE: The incidence of flutamide-related liver toxicity was studied in 56 korean patients, treated for advanced prostate cancer with flutamide combined with a LHRH agonist or orchiectomy. MATERIALS AND... -
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- A case of flutamide-induced acute cholestatic hepatitis: a case report
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Lee HW, Chung JP, Lee KS, Kim KC, Lee KS, Chon CY, Park IS, Kim HG
- KMID: 699896
- Yonsei Med J.
- 1996 Jun;37(3):225-229.
- doi: 10.3349/ymj.1996.37.3.225
Flutamide, an oral nonsteroidal, antiandrogenic, anilid compound which inhibits the uptake and binding of androgens to nuclear receptors in the prostate, is used with or without LH-RH analogues for treatment... -
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- The Therapeutic Effect of Monotherapy and Combined Therapy for Androgen Blockade in Patients with Metastatic Prostate Cancer
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Kim DG, Chang HJ, Lee KS
- KMID: 2293383
- Korean J Urol.
- 2003 Jan;44(1):12-16.
PURPOSE: We evaluated the therapeutic effect of combined androgen blockade (CAB) compared with that of medical, or surgical, castration monotherapy, in the treatment of the metastatic prostate cancer. MATERIALS AND... -
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- Intermittent Androgen Deprivation with Goserelin and Flutamide for Prostate Cancer: a Pilot Study
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Jeon SS, Choi HY
- KMID: 2290125
- Korean J Urol.
- 1999 Oct;40(10):1295-1300.
PURPOSE: The purpose of this study was to evaluate the feasibility of using intermittent androgen deprivation(IAD) in patients with prostate cancer. MATERIALS AND METHODS: We reviewed the medical records of 29... -
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- Effect of antiandrogens upon the morphological development of gubernaculum and the testicular descent in rats
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Han SW, Lee HY, Yang WI, Choi SK
- KMID: 2036828
- Korean J Urol.
- 1992 Apr;33(2):239-249.
We evaluated the effect of antiandrogens on both fetal and adult rats, noting especially the morphological changes in the gubernaculum and testicular descent. Two antiandrogens, flutamide and 5a-reductase inhibitor 4-methyl-4-aza-5-pregnane-3-one-20[s] carboxylate... -
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- Effect of Antiandrogen on Calcitonin Gene-related Peptide Receptor of the Rat Gubernaculum
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Cho SY, Shin MS, Yoon MS
- KMID: 2290356
- Korean J Urol.
- 1999 Jun;40(6):773-780.
PURPOSE: We attempted to investigate whether calcitonin gene-related peptide binding to receptors in the gubernaculum is different between normal and flutamide-treated rats or pups and whether calcitonin gene-related peptide(CGRP) binding... -
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- Effects of Tributyltin Chloride on the Reproductive System in Pubertal Male Rats
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Yu WJ, Nam SY, Kim YC, Lee BJ, Yun YW
- KMID: 1099818
- J Vet Sci.
- 2003 Apr;4(1):29-34.
Detrimental effects of tributyltin (TBT) chloride on the reproductive system were investigated in pubertal male rats. Sixty Sprague-Dawley rats aged with 35 days were assigned to six different groups; negative... -
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- Effects of Intermittent Androgen Suppression in the Treatment of Prostate Cancer: Cycling Changes and Characteristics
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Kim JH, Park CH, Kim CI
- KMID: 2292619
- Korean J Urol.
- 2002 May;43(5):386-390.
PURPOSE: The purpose of this study was to evaluate cycling change and characteristics of treatment in patients receiving intermittent androgen suppression (IAS). MATERIALS AND METHODS: From May 1995 to April 2001,... -
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- Ketoconazole with Prednisolone for the Treatment of Hormone Refractory Prostate Cancer
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Lee BT, Kim CI
- KMID: 2290066
- Korean J Urol.
- 1998 Oct;39(10):1001-1005.
PURPOSE: Corticosteroids suppress the pituitary production of adrenocorticotropic hormone resulting in decreased adrenal steroid production, including adrenal androgens. Ketoconazole is an imidazole fungal agent that inhibit both testicular and adrenal... -
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- Medical Treatment of the Benign Prostatic Hyperplasia
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Chang SG
- KMID: 1936472
- J Korean Med Assoc.
- 2004 Feb;47(2):163-172.
- doi: 10.5124/jkma.2004.47.2.163
The search for nonhormonal pharmacological agents capable of reducing out flow obstruction caused by benign prostatic hyperplasia (BPH) began in the 1970s when alpha adrenergic receptors were demonstrated within the... -
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- Relaxation Response of the Rabbit Clitoral Corpus Cavernosal Smooth Muscle in Chronic Estrogen-Deficiency State
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Kim HW, Seo KK, Lee MY, Kim SC
- KMID: 2292338
- Korean J Urol.
- 2001 Apr;42(4):441-446.
PURPOSE: To investigate involvement of chronic estrogen deficiency in impairment of relaxation response of the clitoral cavernous smooth muscle. MATERIALS AND METHODS: New Zealand white female rabbits were randomly divided... -
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- Bicalutamide-induced Interstitial Lung Disease
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Kim YK, Kim YH, Lee JJ, Choi CW, Yoo JH, Park MJ, Kang HM
- KMID: 2319311
- Tuberc Respir Dis.
- 2010 Apr;68(4):226-230.
Androgen deprivation therapy, which is the standard treatment for metastatic prostate cancer, includes nonsteroidal antiandrogenic drugs, such as flutamide, nilutamide and bicalutamide. Of them, bicalutamide rarely induces interstitial pneumonia. We... -
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- Effects of endocrine disrupting chemicals on expression of phospholipid hydroperoxide glutathione peroxidase mRNA in rat testes
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Baek IJ, Yon JM, Lee SR, Jin Y, Kim MR, Ahn B, Hong JT, Choo YK, Lee BJ, Yun YW, Nam SY
- KMID: 1090793
- J Vet Sci.
- 2007 Sep;8(3):213-218.
- doi: 10.4142/jvs.2007.8.3.213
Phospholipid hydroperoxide glutathione peroxidase(PHGPx), an antioxidative selenoprotein, is modulated byestrogen in the testis and oviduct. To examine whetherpotential endocrine disrupting chemicals (EDCs) affectthe microenvironment of the testes, the expression patternsof... -
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