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Early Experience and the Feasibility of the Firefly Technology for Central Lymph Node Dissection (CLND) in Robotic Thyroidectomy Using the BABA

Choi JA, Lee J, Jung JH, Park HY, Kim WW

In the bilateral axillo-breast approach (BABA), the camera is inserted through the areolar incision, and this raises the concern it might be difficult to identify the lymph nodes (LN). The...
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Marker Gene Transfer into Cells of Rat Achilles Tendon by In Vivo Electroporation

Park JH, Park JW, Lee KS

  • KMID: 2105746
  • J Korean Orthop Assoc.
  • 2001 Jun;36(3):221-226.
PURPOSE: To demonstrate and analyze quantitatively the expression of marker genes in the Achilles tendon of rats by direct DNA injection and electroporation. MATERIALS AND METHODS: Enhanced green fluorescent protein...
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Functional Modification of a Specific RNA with Targeted Trans-Splicing

Park YH, Kim SC, Kwon BS, Jung HS, Kimm K, Lee SW

  • KMID: 1974010
  • Genomics Inform.
  • 2004 Mar;2(1):45-52.
The self-splicing group I intron from Tetrahymena thermophila has been demonstrated to perform splicing reaction with its substrate RNA in the trans configuration. In this study, we explored the potential...
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The Change of c-jun Promoter Activity in TPA-Induced U937 Cells Infected with Human Cytomegalovirus (HCMV)

Park CG, Kim DJ, Kim JH, Han TH, Hwang ES, Choi MS, Kook YH, Choi SB, Cha CY

  • KMID: 2096747
  • J Korean Soc Virol.
  • 1999 Jun;29(2):129-136.
Transient transfection assay has been done to evaluate whether the c-jun activation would be prerequisite to the induction of permissiveness against human cytomegalovirus using in vitro cell model in which...
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Bioluminescence Imaging of Chondrocytes in Rabbits by Intraarticular Injection of D-Luciferin

Moon S, Min JJ, Oh SJ, Kang HS, Kim SM, Kim YH, Kim KY, Bom HS

  • KMID: 1512516
  • Nucl Med Mol Imaging.
  • 2007 Feb;41(1):54-58.
PURPOSE: Luciferase is one of the most commonly used reporter enzymes in the field of in vivo optical imaging. D-luciferin, the substrate for firefly luciferase has very high cost that...
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Targeting Orthotopic Glioma in Mice with Genetically Engineered Salmonella typhimurium

Wen M, Jung S, Moon KS, Jiang SN, Li SY, Min JJ

OBJECTIVE: With the growing interests of bacteria as a targeting vector for cancer treatment, diverse genetically engineered Salmonella has been reported to be capable of targeting primary or metastatic tumor...
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Effects of Testosterone on the Intracavernosally Injected Embryonic Stem Cells in Rat

Oh KJ, Lee HS, Lee MN, Min JJ, Han HJ, Park K

  • KMID: 2298611
  • Korean J Androl.
  • 2006 Aug;24(2):98-103.
PURPOSE: Stem cell-based cell therapy has recently been tried as a way to restore cavernosal function in an animal model. The aim of this study was to elucidate the role...
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Development of Luciferase Reporter Gene-based Cell Bioassay for the Aromatic Hydrocarbon Receptor Agonists

Kim SY, Choi EJ, Yang JH

  • KMID: 1587477
  • Korean J Physiol Pharmacol.
  • 2006 Dec;10(6):349-354.
The aromatic hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates many of the biological and toxicological effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin) and related chemicals. The application of recombinant...
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Measurement of Human Cytochrome P450 Enzyme Induction Based on Mesalazine and Mosapride Citrate Treatments Using a Luminescent Assay

Kim YH, Bae YJ, Kim HS, Cha HJ, Yun JS, Shin JS, Seong WK, Lee YM, Han KM

Drug metabolism mostly occurs in the liver. Cytochrome P450 (CYP) is a drug-metabolizing enzyme that is responsible for many important drug metabolism reactions. Recently, the US FDA and EU EMA...
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Genetic Variants of Thromobomodulin Gene as Risk Factors for Myocardial Infarction

Park HY, Kim Y, Kwon HM, Jee SH, Cho SY, Jang Y

Thrombomodulin (TM) is thrombin receptor present on the luminal surface of endothelial cells. Because the thrombin-TM complex acts as an anticoagulant, the functional variants or deficiency of TM may lead...
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Effects of Intracavernosally Injected Embryonic Stem Cells in Aged Rat

Jung SI, Ryu KH, Youn CW, Lee HS, Park K, Ahn KY, Han HJ

  • KMID: 2226603
  • Korean J Androl.
  • 2007 Aug;25(2):79-84.
PURPOSE: Stem cell-based cell therapy has recently been tried as a way to restore cavernosal function in an animal model. The aims of this study were to elucidate the effect...
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CpG Oligodeoxynucleotides Enhance the Activities of CD8+ Cytotoxic T-Lymphocytes Generated by Combined hMUC1 Vaccination and hNIS Radioiodine Gene Therapy

Jeon YH, Choi Y, Lee J, Kim CW, Chung JK

  • KMID: 1455396
  • Nucl Med Mol Imaging.
  • 2010 Sep;44(3):199-206.
PURPOSE: The authors evaluated whether the cytotoxicity of CD8+CTLs generated by combined hMUC1 vaccination and hNIS radioiodine gene therapy was enhanced in the presence of CpG in an established tumor...
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Prodrug-activating Gene Therapy with Rabbit Cytochrome P450 4B1/4-Ipomeanol or 2-Aminoanthracene System in Glioma Cells

Jang SJ, Kang JH, Lee TS, Kim SJ, Kim KI, Lee YJ, Cheon GJ, Choi CW, Lim SM

  • KMID: 1455395
  • Nucl Med Mol Imaging.
  • 2010 Sep;44(3):193-198.
OBJECTIVE: We determined the cytotoxic properties of cytochrome P450 4B1 (CYP4B1) activated 4-ipomeanol (4-ipo) and 2-aminoanthracene (2-AA) in rat glioma to verify the CYP4B1/4-ipo or 2-AA system for prodrug-activating gene...
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