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High Concentrations of Pamidronate in Bone Weaken the Mechanical Properties of Intact Femora in a Rat Model

Yang KH, Won JH, Yoon HK, Ryu JH, Choo KS, Kim JS

PURPOSE: Bisphosphonates have been used to treat osteoporosis for more than ten years. However, complications associated with long-term administration of bisphosphonates, such as nonunion after pelvic insufficiency fracture or osteonecrosis...
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