- Fatty Acid Composition of Tissue Cultured Breast Carcinoma and the Effect of Stearoyl-CoA Desaturase 1 Inhibition
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Mohammadzadeh F, Mosayebi G, Montazeri , Darabi M, Fayezi S, Shaaker M, Rahmati M, Baradaran , Mehdizadeh A, Darabi M
- KMID: 2353068
- J Breast Cancer.
- 2014 Jun;17(2):136-142.
PURPOSE: Stearoyl-CoA desaturase 1 (SCD1) is a novel therapeutic target in various malignancies, including breast cancer. The present study was designed to investigate the effect of the pharmacologic inhibition of... -
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- Deficiency or activation of peroxisome proliferator-activated receptor α reduces the tissue concentrations of endogenously synthesized docosahexaenoic acid in C57BL/6J mice
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Hsiao WT, Su HM, Su KP, Chen SH, Wu HP, You YL, Fu RH, Chao PM
- KMID: 2453106
- Nutr Res Pract.
- 2019 Aug;13(4):286-294.
- doi: 10.4162/nrp.2019.13.4.286
BACKGROUND/OBJECTIVES: Docosahexaenoic acid (DHA), an n-3 long chain polyunsaturated fatty acid (LCPUFA), is acquired by dietary intake or the in vivo conversion of α-linolenic acid. Many enzymes participating in LCPUFA... -
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- Dehydroepiandrosterone-dependent induction of peroxisomal proliferation can be reduced by aspartyl esterification without attenuation of inhibitory bone loss in ovariectomy animal model
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Kwak CS, Kang CM, Kang HS, Song KY, Lee MS, Seong SC, Park SC
- KMID: 965875
- J Korean Med Sci.
- 2000 Oct;15(5):533-541.
- doi: 10.3346/jkms.2000.15.5.533
The purpose of this study was to determine whether esterification of dehydroepiandrosterone with aspartate (DHEA-aspartate) could reduce peroxisomal proliferation induced by DHEA itself, without loss of antiosteoporotic activity. Female Sprague-Dawley... -
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