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FAM19A5 Deficiency Mitigates the Aβ Plaque Burden and Improves Cognition in Mouse Models of Alzheimer's Disease

Park S, Shahapal A, Yoo S, Kwak H, Lee M, Lee SM, Hwang JI, Seong JY

  • KMID: 2559614
  • Exp Neurobiol.
  • 2024 Aug;33(4):193-201.
  • doi: 10.5607/en24017
FAM19A5, a novel secretory protein highly expressed in the brain, is potentially associated with the progression of Alzheimer's disease (AD). However, its role in the AD pathogenesis remains unclear. Here,...
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Phosphorylated Tau in the Taste Buds of Alzheimer’s Disease Mouse Models

Kim HJ, Kim BH, Kim DK, Kim H, Choi SH, Kim DH, Choi M, Mook-Jung I, Jeong YT, Kwon O

  • KMID: 2559615
  • Exp Neurobiol.
  • 2024 Aug;33(4):202-214.
  • doi: 10.5607/en24004
Numerous systemic diseases manifest with oral symptoms and signs. The molecular diagnosis of Alzheimer’s disease (AD), the most prevalent neurodegenerative disease worldwide, currently relies on invasive or expensive methods, emphasizing...
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Generation of Astrocyte-specific BEST1 Conditional Knockout Mouse with Reduced Tonic GABA Inhibition in the Brain

Joo J, Kim KJ, Lim J, Choi SY, Koh W, Lee CJ

  • KMID: 2559613
  • Exp Neurobiol.
  • 2024 Aug;33(4):180-192.
  • doi: 10.5607/en24019
Bestrophin-1 (BEST1) is a Ca2+ -activated anion channel known for its role in astrocytes. Best1 is permeable to gliotransmitters, including GABA, to contribute to tonic GABA inhibition and modulate synaptic...
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Modulation of Brain-derived Neurotrophic Factor Expression by Physical Exercise in Reserpine-induced Pain-depression Dyad in Mice

Kang DW, Choi SR, Shin H, Lee H, Park J, Lee M, Bae M, Kim HW

  • KMID: 2559612
  • Exp Neurobiol.
  • 2024 Aug;33(4):165-179.
  • doi: 10.5607/en24014
Pain accompanied by depressive symptoms is a common reason for seeking medical assistance, and many chronic pain patients experience comorbid depression. The brain-derived neurotrophic factor (BDNF) is a well-known neurotrophin...
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