- Targeting Microglial and Neuronal Toll-like Receptor 2 in Synucleinopathies
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Kwon S, Iba M, Masliah E, Kim C
- KMID: 2463710
- Exp Neurobiol.
- 2019 Oct;28(5):547-553.
- doi: 10.5607/en.2019.28.5.547
Synucleinopathies are neurodegenerative disorders characterized by the progressive accumulation of α-synuclein (α-syn) in neurons and glia and include Parkinson's disease (PD) and dementia with Lewy bodies (DLB). In this review,... -
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- Cholesterol Metabolism in the Brain and Its Association with Parkinson's Disease
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Jin U, Park SJ, Park SM
- KMID: 2463711
- Exp Neurobiol.
- 2019 Oct;28(5):554-567.
- doi: 10.5607/en.2019.28.5.554
Parkinson's disease (PD) is the second most progressive neurodegenerative disorder of the aging population after Alzheimer’s disease (AD). Defects in the lysosomal systems and mitochondria have been suspected to cause... -
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- Modulation of Dopaminergic Neuronal Excitability by Zinc through the Regulation of Calcium-related Channels
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Noh J, Chung JM
- KMID: 2463713
- Exp Neurobiol.
- 2019 Oct;28(5):578-592.
- doi: 10.5607/en.2019.28.5.578
Depending on the intracellular buffering of calcium by chelation, zinc has the following two apparent effects on neuronal excitability: enhancement or reduction. Zinc increased tonic activity in the depolarized state... -
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- A Computational Modeling Reveals That Strength of Inhibitory Input, E/I Balance, and Distance of Excitatory Input Modulate Thalamocortical Bursting Properties
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Park S, Sohn JW, Cho J, Huh Y
- KMID: 2463712
- Exp Neurobiol.
- 2019 Oct;28(5):568-577.
- doi: 10.5607/en.2019.28.5.568
The thalamus is a brain structure known to modulate sensory information before relaying to the cortex. The unique ability of a thalamocortical (TC) neuron to switch between the high frequency... -
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- 3-Carene, a Phytoncide from Pine Tree Has a Sleep-enhancing Effect by Targeting the GABA(A)-benzodiazepine Receptors
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Woo J, Yang H, Yoon M, Gadhe CG, Pae AN, Cho S, Lee CJ
- KMID: 2463714
- Exp Neurobiol.
- 2019 Oct;28(5):593-601.
- doi: 10.5607/en.2019.28.5.593
3-Carene, a bicyclic monoterpene, is one of the major components of the pine tree essential oils. It has been reported that, in addition to its known properties as a phytoncide,... -
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- Transduced Tat-aldose Reductase Protects Hippocampal Neuronal Cells against Oxidative Stress-induced Damage
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Cho SB, Eum WS, Shin MJ, Kwon HJ, Park JH, Choi YJ, Park J, Han KH, Kang JH, Kim DS, Cho SW, Kim DW, Choi SY
- KMID: 2463716
- Exp Neurobiol.
- 2019 Oct;28(5):612-627.
- doi: 10.5607/en.2019.28.5.612
Aldose reductase (AR) protein, a member of the NADPH-dependent aldo-keto reductase family, reduces a wide range of aldehydes and enhances cell survival by inhibition of oxidative stress. Oxidative stress is... -
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- LGR5 and Downstream Intracellular Signaling Proteins Play Critical Roles in the Cell Proliferation of Neuroblastoma, Meningioma and Pituitary Adenoma
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Hwang M, Han MH, Park HH, Choi H, Lee KY, Lee YJ, Kim JM, Cheong JH, Ryu JI, Min KW, Oh YH, Ko Y, Koh SH
- KMID: 2463717
- Exp Neurobiol.
- 2019 Oct;28(5):628-641.
- doi: 10.5607/en.2019.28.5.628
Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) has been reported to play critical roles in the proliferation of various cancer cells. However, the roles of LGR5 in brain tumors and... -
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- Combination of In Vivo [¹²³I]FP-CIT SPECT and Microdialysis Reveals an Antipsychotic Drug Haloperidol-induced Synaptic Dopamine Availability in the Rat Midbrain and Striatum
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Park SH, Song YS, Moon BS, Lee BC, Park HS, Kim SE
- KMID: 2463715
- Exp Neurobiol.
- 2019 Oct;28(5):602-611.
- doi: 10.5607/en.2019.28.5.602
Synaptic dopamine (DA) is mainly regulated by the presynaptic DA transporter (DAT). Single-photon emission computerized tomography (SPECT) with the DAT radiotracer [¹²³I]FP-CIT assesses changes in synaptic DA availability when endogenous... -
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