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Neuro-Behcet's Disease Presenting as Hypertrophic Pachymeningitis

Yoon BN, Kim SJ, Lim MJ, Han JY, Lee KW, Sung JJ, Ha CK, Choi SH

A 25-year-old man presented with blurred vision and chronic headache. His brain MRI revealed bilateral frontal pachymeningeal enhancement with leptomeningeal enhancement. The patient had experienced recurrent oral ulcer and had...
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Specific Expression of Aplysia Phosphodiesterase 4 in Bag Cells Revealed by in situ Hybridization Analysis

Jang DJ, Kim HF, Sim JH, Lim CS, Kaang BK

Phosphodiesterases (PDEs) play a key role in the regulation of cyclic adenosine monophosphate (cAMP), which in turn mediates various cellular functions including learning and memory. We previously cloned and characterized...
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The Unreliability of MTT Assay in the Cytotoxic Test of Primary Cultured Glioblastoma Cells

Jo HY, Kim Y, Park HW, Moon HE, Bae S, Kim J, Kim DG, Paek SH

MTT assay is commonly used to assess the cellular cytotoxicity caused by anticancer drugs in glioblastomas. However, there have been some reports insisting that MTT assay exhibited non-specific intracellular reduction...
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Modulation of SOD1 Subcellular Localization by Transfection with Wild- or Mutant-type SOD1 in Primary Neuron and Astrocyte Cultures from ALS Mice

Lee DY, Jeon GS, Shim YM, Seong SY, Lee KW, Sung JJ

Amyotrophic lateral sclerosis (ALS) is a fatal neurological disorder characterized by selective degeneration of motor neurons. Mutant superoxide dismutase 1 (SOD1) is often found as aggregates in the cytoplasm in...
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Control of Mitochondrial Dynamics by Fas-induced Caspase-8 Activation in Hippocampal Neurons

Cho HM, Sun W

Cells undergo apoptosis mainly via two pathways-the mitochondrial pathway and the cytosolic pathway. It has been well documented that activation of the mitochondrial pathway promotes mitochondrial fragmentation and inhibition of...
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Disinhibitory Action of Astrocytic GABA at the Perforant Path to Dentate Gyrus Granule Neuron Synapse Reverses to Inhibitory in Alzheimer's Disease Model

Yarishkin , Lee J, Jo S, Hwang EM, Lee CJ

Like neurons, astrocytes produce and release GABA to influence neuronal signaling. At the perforant path to dentate gyrus granule neuron synapse, GABA from astrocyte was found to be a strong...
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Membrane-Introduction Mass Spectrometry Analysis of Desflurane, Propofol and Fentanyl in Plasma and Cerebrospinal Fluid for Estimation BBB Properties

Cherebillo VY, Elizarov A, Polegaev A

A possibility to use the Membrane-Introduction Mass Spectrometry (MIMS) with membrane separator interface has evolved into a powerful method for measurement of anaesthetic agents absolute concentration in blood plasma and...
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Glucose Levels in Culture Medium Determine Cell Death Mode in MPP+-treated Dopaminergic Neuronal Cells

Yoon SY, Oh YJ

We previously demonstrated that 1-methyl-4-phenylpyridinium (MPP+) causes caspase-independent, non-apoptotic death of dopaminergic (DA) neuronal cells. Here, we specifically examined whether change of glucose concentration in culture medium may play a...
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Peripheral Biomarker Candidates of Posttraumatic Stress Disorder

Kang HJ, Yoon S, Lyoo IK

There is high variability in the manifestation of physical and mental health problems following exposure to trauma and disaster. Although most people may show a range of acute symptoms in...
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Roles of mTOR Signaling in Brain Development

Lee DY

mTOR is a serine/threonine kinase composed of multiple protein components. Intracellular signaling of mTOR complexes is involved in many of physiological functions including cell survival, proliferation and differentiation through the...
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