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Letter to the Editor: Hypothesis: Somatic Mosaicism and Parkinson Disease

Perandones C, Pellene LA, Giugni JC, Calvo DS, Raina GB, Cuevas SM, Mata IF, Zabetian C, Caputo M, Corach D, Micheli FE, Radrizzani M

No abstract available.
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Balo's Concentric Sclerosis Mimicking Cerebral Tuberculoma

Son YR, Yang H, Lee S, Kim JY, Han SG, Park KS

Balo's concentric sclerosis (BCS) is considered a rare variant of multiple sclerosis, which often mimics an intracranial neoplasm or abscess. We report the case of a 21-year-old woman presenting with...
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Chronic Antidepressant Treatment in Normal Mice Induces Anxiety and Impairs Stress-coping Ability

Baek IS, Park JY, Han PL

Antidepressants are clinically used for patients with major depression. Antidepressant treatments in certain groups of patients are effective for relieving depression as well as anxiety disorder. However, it is not...
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The Effect of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells in a Collagenase-Induced Intracerebral Hemorrhage Rat Model

Kim K, Park HW, Moon HE, Kim JW, Bae S, Chang JW, Oh W, Yang YS, Paek SH

Intracerebral hemorrhage (ICH) is one of the devastating types of stroke. Human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) have potential benefits in recovery from brain damage following ICH. This...
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Curcumin Ameliorates Functional and Structural Abnormalities in Cisplatin-induced Neuropathy

Agthong S, Kaewsema A, Charoensub T

Peripheral neuropathy is one of the major side effects of cisplatin; however, effective treatments are lacking. Curcumin is a polyphenol found in the root of Curcuma longa and has been...
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Growth Differentiation Factor 15 Expression in Astrocytes After Excitotoxic Lesion in the Mouse Hippocampus

Yi MH, Zhang E, Baek H, Kim S, Shin N, Kang JW, Lee S, Oh SH, Kim DW

Growth differentiation factor 15 (GDF15) is, a member of the transforming growth factor beta (TGF-beta) superfamily of proteins. Although GDF15 is well established as a potent neurotrophic factor for neurons,...
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Aberrant Thalamocortical Synchrony Associated with Behavioral Manifestations in Git1-/- Mice

Mah W

Cross-talk between the thalamus and cortex has been implicated in attention but its pathogenic role in attention-deficit/hyperactivity disorder (ADHD) remains unknown. Here, I demonstrate that Git1-/- mice, previously proposed as...
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miR-Let7A Modulates Autophagy Induction in LPS-Activated Microglia

Song J, Oh Y, Lee JE

Microglia regulate the secretion of various immunomediators in central nervous system diseases. Microglial autophagy is the crucial process for cell's survival and cytokine productions. Recent studies have reported that several...
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Mitochondrial Dysfunction in Parkinson's Disease

Moon HE, Paek SH

Parkinson's disease (PD) is characterized by the selective loss of dopaminergic neurons of the substantia nigra pars compacta (SNc) with motor and nonmotor symptoms. Defective mitochondrial function and increased oxidative...
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Control of Inflammatory Responses: a New Paradigm for the Treatment of Chronic Neuronal Diseases

Woo JH, Lee JH, Kim H, Park SJ, Joe EH, Jou I

The term 'inflammation' was first introduced by Celsus almost 2000 years ago. Biological and medical researchers have shown increasing interest in inflammation over the past few decades, in part due...
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