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Hereditary Spastic Paraplegia with a Novel SPAST Mutation Misdiagnosed with Subacute Combined Degeneration

Yang JW, Han JY, Seong MW, Sung JJ, Park SS, Lee KW

Autosomal dominant hereditary spastic paraplegia (AD-HSP) is due to mutations in the "spastin" gene (SPAST gene) encoding the AAA protein. The main clinical features of "pure" HSP are progressive lower-limb...
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Effect of Food Deprivation on a Delayed Nonmatch-to-place T-maze Task

Jang EH, Ahn SH, Lee YS, Lee HR, Kaang BK

Food deprivation can affect performance on difficult cognitive task, such as the delayed nonmatch-to-place T-maze task (DNMT). The importance of food deprivation on maintaining high motivation for DNMT task has...
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Tamoxifen Mimics the Effects of Endogenous Ovarian Hormones on Repeated Seizures Induced by Pentylenetetrazole in Rats

Mansouri S, Ataei ML, Hosseini M, Bideskan A

In the present study, the effects of tamoxifen on pentylenetetrazole (PTZ)-induced repeated seizures and hippocampal neuronal damage in ovariectomized rats were investigated. Thirty seven virgin female Wistar rats were divided...
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Glycyrrhizin Attenuates Kainic Acid-Induced Neuronal Cell Death in the Mouse Hippocampus

Luo L, Jin Y, Kim ID, Lee JK

Glycyrrhizin (GL), a triterpene that is present in the roots and rhizomes of licorice (Glycyrrhiza glabra), has been reported to have anti-inflammatory and anti-viral effects. Recently, we demonstrated that GL...
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Protective Effects of Curcumin and Sertraline on the Behavioral Changes in Chronic Variable Stress-Induced Rats

Noorafshan A, Abdollahifar MA, Karbalay-Doust S, Asadi-Golshan R, Rashidian-Rashidabadi A

Behavioral characteristics of the animal models and humans are impaired in chronic stress. The present study aimed to evaluate and compare the protective effects of sertraline and curcumin on stress-induced...
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An Update of Animal Models of Alzheimer Disease with a Reevaluation of Plaque Depositions

Lee JE, Han PL

Animal models of Alzheimer disease (AD) are used to study the mechanisms underlying AD pathogenesis, genetic interactions with genes of interest, and environmental risk factors that cause sporadic AD as...
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Alpha-Synuclein Expression in Patients with Parkinson's Disease: A Clinician's Perspective

Kim HJ

Although physiological function of alpha-synuclein is not yet clearly understood, accumulating evidence strongly suggests it plays a crucial role in the pathogenesis of Parkinson disease. Pathologically, alpha-synuclein is a major...
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Role of Glial Cells in Axonal Regeneration

Toy D, Namgung U

Axonal regeneration is critical for functional recovery following neural injury. In addition to intrinsic differences between regenerative responses of axons in peripheral versus central nervous systems, environmental factors such as...
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Brain Inflammation and Microglia: Facts and Misconceptions

Jeong HK, Ji K, Min K, Joe EH

The inflammation that accompanies acute injury has dual functions: bactericidal action and repair. Bactericidal functions protect damaged tissue from infection, and repair functions are initiated to aid in the recovery...
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