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Anti-LGI1 Limbic Encephalitis Presented with Atypical Manifestations

Lee JJ, Lee ST, Jung KH, Chu K, Lee SK

Anti-leucine-rich glioma inactivated-1 (LGI1) limbic encephalitis (LE) is a rare neurological disorder that has a subacute course of progressive encephalopathy and fasciobrachial dystonic seizures. We report a patient with anti-LGI1...
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Reliability and Validity of the Korean Version of the Lifespan Sibling Relationship Scale

Jeong HS, Jeong EJ, Yu SY, Lyoo YC, Im JJ, Bae S, Kim JE

The sibling relationship and its potential impact on neurodevelopment and mental health are important areas of neuroscientific research. Validation of the tools assessing the quality of the sibling relationship would...
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Developmental Role of Anoctamin-1/TMEM16A in Ca2+-Dependent Volume Change in Supporting Cells of the Mouse Cochlea

Yi E, Lee J, Lee CJ

Mammalian cochlea undergoes morphological and functional changes during the postnatal period, around the hearing onset. Major changes during the initial 2 postnatal weeks of mouse include maturation of sensory hair...
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Zinc-Triggered Induction of Tissue Plasminogen Activator and Plasminogen in Endothelial Cells and Pericytes

Cho MK, Sun ES, Kim YH

Cerebral amyloid angiopathy (CAA) is common in patients with Alzheimer's disease (AD) and may contribute to cerebral hemorrhage. We previously demonstrated that tissue plasminogen activator (tPA) and plasminogen (PLG) accumulated...
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Absence of Delayed Neuronal Death in ATP-Injected Brain: Possible Roles of Astrogliosis

Jeong HK, Jou I, Joe EH

Although secondary delayed neuronal death has been considered as a therapeutic target to minimize brain damage induced by several injuries, delayed neuronal death does not occur always. In this study,...
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HMGB1-Binding Heptamer Confers Anti-Inflammatory Effects in Primary Microglia Culture

Kim ID, Lee JK

High mobility group box 1 (HMGB1) is an endogenous danger signal molecule. In the postischemic brain, HMGB1 is massively released during NMDA-induced acute damage and triggers inflammatory processes. In a...
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Mitochondrial Dysfunction of Immortalized Human Adipose Tissue-Derived Mesenchymal Stromal Cells from Patients with Parkinson's Disease

Moon HE, Yoon SH, Hur YS, Park HW, Ha JY, Kim KH, Shim JH, Yoo SH, Son JH, Paek SL, Kim IK, Hwang JH, Kim DG, Kim HJ, Jeon BS, Park SS, Paek SH

Mitochondrial dysfunction in dopaminergic neurons of patients with idiopathic and familial Parkinson's disease (PD) is well known although the underlying mechanism is not clear. We established a homogeneous population of...
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Distribution of the Immunoreactivity for Glycoprotein M6B in the Neurogenic Niche and Reactive Glia in the Injury Penumbra Following Traumatic Brain Injury in Mice

Choi KM, Kim JY, Kim Y

The location and morphology of astrocytes are known to contribute to their diversity, and this diversity is often associated with their selective functions. However, molecular markers for astrocyte subtypes are...
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The Effect of Agmatine on Expression of IL-1beta and TLX Which Promotes Neuronal Differentiation in Lipopolysaccharide-Treated Neural Progenitors

Song J, Kumar BK, Kang S, Park KA, Lee WT, Lee JE

Differentiation of neural progenitor cells (NPCs) is important for protecting neural cells and brain tissue during inflammation. Interleukin-1 beta (IL-1beta) is the most common pro- inflammatory cytokine in brain inflammation,...
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Curcumin Can Prevent the Changes in Cerebellar Structure and Function Induced by Sodium Metabisulfite in Rat

Noorafshan A, Rashidiani-Rashidabadi A, Karbalay-Doust S, Poostpasand A, Abdollahifar MA, Asadi-Golshan R

Sulfites are used as anti-microbial and anti-oxidant agents in the food and pharmaceutical industries. Curcumin, a flavonoid, is an Asian spice that shows neuroprotective activities. The current study aimed to...
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LRRK2 as a Potential Genetic Modifier of Synucleinopathies: Interlacing the Two Major Genetic Factors of Parkinson's Disease

Hyun CH, Yoon CY, Lee HJ, Lee SJ

Parkinson's disease (PD) and related Lewy body diseases are characterized by deposition of alpha-synuclein aggregates in both the central nervous system and peripheral nervous system. Synucleinopathy lesions spread to larger...
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New Perspectives of Dyrk1A Role in Neurogenesis and Neuropathologic Features of Down Syndrome

Park J, Chung KC

Down syndrome (DS) is one of the most common genetic disorders accompanying with mental retardation, cognitive impairment, and deficits in learning and memory. The brains with DS also display many...
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Involvement of Genetic and Environmental Factors in the Onset of Depression

Nabeshima , Kim HC

First, this article provides a brief overview of the previous hypotheses regarding depression and then focuses on involvement of genetic and environmental factors in development of depression. According to epidemiological...
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