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Akkermansia muciniphila-derived extracellular vesicles influence gut permeability through the regulation of tight junctions

Chelakkot , Choi Y, Kim DK, Park HT, Ghim J, Kwon Y, Jeon J, Kim MS, Jee YK, Gho YS, Park HS, Kim YK, Ryu SH

The gut microbiota has an important role in the gut barrier, inflammation and metabolic functions. Studies have identified a close association between the intestinal barrier and metabolic diseases, including obesity...
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Inhibition of TNFα-interacting protein α (Tipα)-associated gastric carcinogenesis by BTG2(/TIS21) via downregulating cytoplasmic nucleolin expression

Devanand P, Oya Y, Sundaramoorthy S, Song KY, Watanabe T, Kobayashi , Shimizu Y, Hong SA, Suganuma M, Lim IK

To understand the regulation of Helicobacter pylori (H. pylori)-associated gastric carcinogenesis, we examined the effect of B-cell translocation gene 2 (BTG2) expression on the biological activity of Tipα, an oncoprotein...
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Suppression of the ERK–SRF axis facilitates somatic cell reprogramming

Huh S, Song HR, Jeong GR, Jang H, Seo NH, Lee JH, Yi JY, Lee B, Choi HW, Do JT, Kim JS, Lee SH, Jung JW, Lee T, Shim J, Han MK, Lee TH

The molecular mechanism underlying the initiation of somatic cell reprogramming into induced pluripotent stem cells (iPSCs) has not been well described. Thus, we generated single-cell-derived clones by using a combination...
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The long non-coding RNA uc.4 influences cell differentiation through the TGF-beta signaling pathway

Cheng Z, Zhang Q, Yin A, Feng M, Li H, Liu H, Li Y, Qian L

In a previous study, we screened thousands of long non-coding RNAs (lncRNAs) to assess their potential relationship with congenital heart disease (CHD). In this study, uc.4 attracted our attention because...
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Nucleophosmin modulates the alleviation of atopic dermatitis caused by the marine-derived compound dihydroaustrasulfone alcohol

Hung HC, Feng CW, Lin YY, Chen CH, Tsui KH, Chen WF, Pan CY, Sheu JH, Sung CS, Wen ZH

Atopic dermatitis (AD) is a chronic inflammatory skin disease, and its prevalence is increasing. AD usually elicits skin barrier dysfunction, dry skin and itching. As the mechanisms of AD remain...
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Macrophage migration inhibitory factor mediates peripheral nerve injury-induced hypersensitivity by curbing dopaminergic descending inhibition

Wang X, Ma S, Wu H, Shen X, Xu S, Guo X, Bolick ML, Wu S, Wang F

Our previous works disclosed the contributing role of macrophage migration inhibitory factor (MIF) and dopaminergic inhibition by lysine dimethyltransferase G9a/Glp complex in peripheral nerve injury-induced hypersensitivity. We herein propose that...
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PI3Kδ contributes to ER stress-associated asthma through ER-redox disturbances: the involvement of the RIDD–RIG-I–NF-κB axis

Kim HK, Lee GH, Bhattarai , Junjappa R, Lee HY, Handigund , Marahatta , Bhandary B, Baek IH, Pyo JS, Kim HK, Chai OH, Kim HR, Lee YC, Chae HJ

Hyperactivation of phosphoinositol 3-kinase (PI3K) has been suggested to be a potential mechanism for endoplasmic reticulum (ER) stress-enhanced airway hyperresponsiveness, and PI3K inhibitors have been examined as asthma therapeutics. However,...
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Silencing of peroxiredoxin II by promoter methylation is necessary for the survival and migration of gastric cancer cells

Hong SH, Min C, Jun Y, Lee DJ, Kim SH, Park JH, Cheong JH, Park YJ, Kim SY, Lee S, Kang SW

Peroxiredoxin (Prx), a family of ubiquitous thiol peroxidases, functions as a redox signaling regulator that controls cellular Hâ‚‚Oâ‚‚ in mammalian cells and has recently received attention for being overexpressed in...
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Mutational signatures and chromosome alteration profiles of squamous cell carcinomas of the vulva

Han MR, Shin S, Park HC, Kim MS, Lee SH, Jung SH, Song SY, Lee SH, Chung YJ

Vulvar squamous cell carcinoma (SCC) consists of two different etiologic categories: human papilloma virus (HPV)-associated (HPV (+)) and HPV-non-associated (HPV (−)). There have been no genome-wide studies on the genetic...
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Poly(rC) binding protein 2 acts as a negative regulator of IRES-mediated translation of Hr mRNA

Kim JK, Kim I, Choi K, Choi JH, Kim E, Lee HY, Park J, Kim Yoon S

During the hair follicle (HF) cycle, HR protein expression is not concordant with the presence of the Hr mRNA transcript, suggesting an elaborate regulation of Hr gene expression. Here we...
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Protection of nigral dopaminergic neurons by AAV1 transduction with Rheb(S16H) against neurotoxic inflammation in vivo

Kim S, Moon GJ, Oh YS, Park J, Shin WH, Jeong JY, Choi KS, Jin BK, Kholodilov N, Burke RE, Kim HJ, Ha CM, Lee SG, Kim SR

We recently reported that adeno-associated virus serotype 1 (AAV1) transduction of murine nigral dopaminergic (DA) neurons with constitutively active ras homolog enriched in brain with a mutation of serine to...
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Integrin CD11b negatively regulates Mincle-induced signaling via the Lyn–SIRPα–SHP1 complex

Zhang Q, Lee WB, Kang JS, Kim LK, Kim YJ

During mycobacteria infection, anti-inflammatory responses allow the host to avoid tissue damage caused by overactivation of the immune system; however, little is known about the negative modulators that specifically control...
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Arginase II inhibition prevents interleukin-8 production through regulation of p38 MAPK phosphorylation activated by loss of mitochondrial membrane potential in nLDL-stimulated hAoSMCs

Koo BH, Yi BG, Jeong MS, Kwon SH, Hoe KL, Kwon YG, Won MH, Kim YM, Ryoo S

Arginase inhibition exhibits beneficial effects in vascular endothelial and smooth muscle cells. In human aortic smooth muscle cells (hAoSMCs), native low-density lipoprotein (nLDL) induced the production of interleukin-8 (IL-8) that...
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4-hydroxy-3-methoxycinnamic acid regulates orexigenic peptides and hepatic glucose homeostasis through phosphorylation of FoxO1

Kinyua AW, Ko CM, Doan KV, Yang DJ, Huynh MK, Moh SH, Choi YH, Kim KW

4-hydroxy-3-methoxycinnamic acid (ferulic acid, FA) is known to have numerous beneficial health effects, including anti-obesity and anti-hyperglycemic properties. However, the molecular networks that modulate the beneficial FA-induced metabolic effects have...
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Differential regulation of hepcidin in cancer and non-cancer tissues and its clinical implications

Vela D, Vela-Gaxha Z

Hepcidin is a crucial peptide for regulating cellular iron efflux. Because iron is essential for cell survival, especially for highly active cells, such as tumor cells, it is imperative to...
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