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Carbon monoxide prevents TNF-α-induced eNOS downregulation by inhibiting NF-κB-responsive miR-155-5p biogenesis

Choi S, Kim J, Kim JH, Lee DK, Park W, Park M, Kim S, Hwang JY, Won MH, Choi YK, Ryoo S, Ha KS, Kwon YG, Kim YM

Heme oxygenase-1-derived carbon monoxide prevents inflammatory vascular disorders. To date, there is no clear evidence that HO-1/CO prevents endothelial dysfunction associated with the downregulation of endothelial NO synthesis in human...
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Leukotriene B(4) receptor 2 gene polymorphism (rs1950504, Asp196Gly) leads to enhanced cell motility under low-dose ligand stimulation

Jang JH, Wei JD, Kim M, Kim JY, Cho AE, Kim JH

Recently, single-nucleotide polymorphisms (SNPs) in G-protein-coupled receptors (GPCRs) have been suggested to contribute to physiopathology and therapeutic effects. Leukotriene B4 receptor 2 (BLT2), a member of the GPCR family, plays...
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Trib2 regulates the pluripotency of embryonic stem cells and enhances reprogramming efficiency

Do EK, Park JK, Cheon HC, Kwon YW, Heo SC, Choi EJ, Seo JK, Jang IH, Lee SC, Kim JH

Embryonic stem (ES) cells are pluripotent cells characterized by self-renewability and differentiation potential. Induced pluripotent stem (iPS) cells are ES cell-equivalent cells derived from somatic cells by the introduction of...
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Generation of an osteoblast-based artificial niche that supports in vitro B lymphopoiesis

Yu J, Choi S, Kim H, Lee N, Yun H, Kim S, Jeong ST, Rho J

B lymphocytes are produced from hematopoietic stem cells (HSCs) through the highly ordered process of B lymphopoiesis, which is regulated by a complex network of cytokines, chemokines and cell adhesion...
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Therapeutic inhibition of SGK1 suppresses colorectal cancer

Liang X, Lan C, Jiao G, Fu W, Long X, An Y, Wang K, Zhou J, Chen T, Li Y, Xu J, Huang Q, Xu B, Xiao J

Colorectal cancer (CRC) is one of the leading causes of death worldwide. Thus, the development of new therapeutic targets for CRC treatment is urgently needed. SGK1 is involved in various...
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Participation of GATA-3 in regulation of bone healing through transcriptional upregulation of bcl-x(L) expression

Liao MH, Lin PI, Ho WP, Chan WP, Chen TL, Chen RM

We have previously demonstrated the expression of GATA-DNA-binding protein (GATA)-3, a transcription factor, in osteoblasts and have verified its function in transducing cell survival signaling. This translational study was further...
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Are the view of Helicobacter pylori colonized in the oral cavity an illusion?

Yee JK

Urea breath test (UBT), as a leading preferred non-invasive diagnostic technology, but may not be able to detect oral H. pylori. With negative results of UBT, the patient may have...
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Integrin alpha 11 in the regulation of the myofibroblast phenotype: implications for fibrotic diseases

Bansal R, Nakagawa S, Yazdani S, van Baarlen J, Venkatesh , Koh AP, Song WM, Goossens N, Watanabe H, Beasley MB, Powell CA, Storm G, Kaminski N, van Goor H, Friedman S, Hoshida Y, Prakash J

Tissue fibrosis, characterized by excessive accumulation of aberrant extracellular matrix (ECM) produced by myofibroblasts, is a growing cause of mortality worldwide. Understanding the factors that induce myofibroblastic differentiation is paramount...
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Epithelial folliculin is involved in airway inflammation in workers exposed to toluene diisocyanate

Pham DL, Trinh TH, Ban GY, Kim SH, Park HS

Toluene diisocyanate (TDI) exposure can directly activate and damage airway epithelium. Folliculin (FLCN) is a protein expressed by human airway epithelial cells (HAECs) to maintain airway epithelial integrity and survival....
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Lower serum extracellular superoxide dismutase levels are associated with polyneuropathy in recent-onset diabetes

Strom A, Kaul K, Brüggemann J, Ziegler I, Rokitta I, Püttgen S, Szendroedi J, Müssig K, Roden M, Ziegler D, GDS Group

Increased oxidative stress is implicated in the pathogenesis of experimental diabetic neuropathy, but translational evidence in recent-onset diabetes is scarce. We aimed to determine whether markers of systemic oxidative stress...
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The transcription factor Batf3 inhibits the differentiation of regulatory T cells in the periphery

Lee W, Kim HS, Hwang SS, Lee GR

Naive CD4 T cells activated by antigen-presenting cells (APCs) undergo terminal differentiation in the periphery. Multiple mechanisms determine their fates, that is, whether they differentiate into conventional T (Tconv) cells...
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Piperidylmethyloxychalcone improves immune-mediated acute liver failure via inhibiting TAK1 activity

Park SH, Kwak JA, Jung SH, Ahn B, Cho WJ, Yun CY, Na CS, Hwang BY, Hong JT, Han SB, Kim Y

Mice deficient in the toll-like receptor (TLR) or the myeloid differentiation factor 88 (MyD88) are resistant to acute liver failure (ALF) with sudden death of hepatocytes. Chalcone derivatives from medicinal...
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Mitochondrial UQCRB as a new molecular prognostic biomarker of human colorectal cancer

Kim HC, Chang J, Lee HS, Kwon HJ

Ubiquinol cytochrome c reductase binding protein (UQCRB) is important for mitochondrial complex III stability, electron transport, cellular oxygen sensing and angiogenesis. However, its potential as a prognostic marker in colorectal...
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Modulating cellular balance of Rps3 mono-ubiquitination by both Hel2 E3 ligase and Ubp3 deubiquitinase regulates protein quality control

Jung Y, Kim HD, Yang HW, Kim HJ, Jang CY, Kim J

When a ribosome complex is stalled during the translation elongation process in eukaryotes, the mono-ubiquitination of Rps3 has recently been shown to be critical to ribosome quality control. We have...
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Implications of aging and the endoplasmic reticulum unfolded protein response on the molecular modality of breast cancer

Minakshi R, Rahman S, Jan AT, Archana A, Kim J

The endoplasmic reticulum (ER) is an important subcellular organelle that is involved in numerous activities required to achieve and maintain functional proteins in addition to its role in the biosynthesis...
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IL-33 promotes IL-10 production in macrophages: a role for IL-33 in macrophage foam cell formation

Zhang HF, Wu MX, Lin YQ, Xie SL, Huang TC, Liu PM, Nie RQ, Meng QQ, Luo NS, Chen YX, Wang JF

We evaluated the role of IL-10- in IL-33-mediated cholesterol reduction in macrophage-derived foam cells (MFCs) and the mechanism by which IL-33 upregulates IL-10. Serum IL-33 and IL-10 levels in coronary...
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