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cAMP signaling increases histone deacetylase 8 expression via the Epac2–Rap1A–Akt pathway in H1299 lung cancer cells

Park JY, Juhnn YS

This study was performed to investigate the signaling pathway that mediates cyclic AMP (cAMP)-induced inhibition of histone deacetylase 8 (HDAC8) degradation, and the effect and underlying mechanisms of the resulting...
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Resveratrol suppresses breast cancer cell invasion by inactivating a RhoA/YAP signaling axis

Kim YN, Choe SR, Cho KH, Cho DY, Kang J, Park CG, Lee HY

Hippo/YAP signaling is implicated in tumorigenesis and progression of various cancers. By inhibiting a plethora signaling cascades, resveratrol has strong anti-tumorigenic and anti-metastatic activity. In the present study, we demonstrate...
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NF-κB signaling regulates cell-autonomous regulation of CXCL10 in breast cancer 4T1 cells

Jin WJ, Kim B, Kim D, Park Choo , Kim HH, Ha H, Lee ZH

The chemokine CXCL10 and its receptor CXCR3 play a role in breast cancer metastasis to bone and osteoclast activation. However, the mechanism of CXCL10/CXCR3-induced intracellular signaling has not been fully...
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Ig-like domain 6 of VCAM-1 is a potential therapeutic target in TNFα-induced angiogenesis

Kim TK, Park CS, Na HJ, Lee K, Yoon A, Chung J, Lee S

Tumor necrosis factor alpha (TNFα)-induced angiogenesis plays important roles in the progression of various diseases, including cancer, wet age-related macular degeneration, and rheumatoid arthritis. However, the relevance and role of...
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Hepatitis B virus X protein-mediated non-coding RNA aberrations in the development of human hepatocellular carcinoma

Zhang B, Han S, Feng B, Chu X, Chen L, Wang R

Hepatitis B virus (HBV) has an important role in the development of human hepatocellular carcinoma (HCC). Accumulated evidence has shown that HBV-encoded X protein (HBx) can induce both genetic alterations...
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HOXC10 suppresses browning of white adipose tissues

Ng Y, Tan SX, Chia SY, Tan HY, Gun SY, Sun L, Hong W, Han W

Given that increased thermogenesis in white adipose tissue, also known as browning, promotes energy expenditure, significant efforts have been invested to determine the molecular factors involved in this process. Here...
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Oxidative stress and calcium dysregulation by palmitate in type 2 diabetes

Ly LD, Xu S, Choi SK, Ha CM, Thoudam T, Cha SK, Wiederkehr A, Wollheim C, Lee IK, Park KS

Free fatty acids (FFAs) are important substrates for mitochondrial oxidative metabolism and ATP synthesis but also cause serious stress to various tissues, contributing to the development of metabolic diseases. CD36...
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Therapeutic effect of the immunomodulatory drug lenalidomide, but not pomalidomide, in experimental models of rheumatoid arthritis and inflammatory bowel disease

Lopez-Millan B, Diaz de la Guardia R, Roca-Ho H, García-Herrero CM, Lavoie JR, Rosu-Myles M, Gonzalez-Rey E, O'Valle F, Criado G, Delgado M, Menendez P

Thalidomide is an immunomodulatory drug (IMiD) with proven therapeutic action in several autoimmune/inflammatory diseases; however, its inherent high toxicity has led to the development of more powerful and safer thalidomide...
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