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CCCTC-binding factor is essential to the maintenance and quiescence of hematopoietic stem cells in mice

Kim TG, Kim S, Jung S, Kim M, Yang B, Lee MG, Kim HP

Hematopoiesis involves a series of lineage differentiation programs initiated in hematopoietic stem cells (HSCs) found in bone marrow (BM). To ensure lifelong hematopoiesis, various molecular mechanisms are needed to maintain...
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Enteric dysbiosis-linked gut barrier disruption triggers early renal injury induced by chronic high salt feeding in mice

Hu J, Luo H, Wang J, Tang W, Lu J, Wu S, Xiong Z, Yang G, Chen Z, Lan T, Zhou H, Nie J, Jiang Y, Chen P

Chronic high-salt diet-associated renal injury is a key risk factor for the development of hypertension. However, the mechanism by which salt triggers kidney damage is poorly understood. Our study investigated...
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Serum amyloid A inhibits dendritic cell differentiation by suppressing GM-CSF receptor expression and signaling

Kim JC, Jung YS, Lee HY, Park JS, Bae YS

In this study, we report that an acute phase reactant, serum amyloid A (SAA), strongly inhibits dendritic cell differentiation induced by GM-CSF plus IL-4. SAA markedly decreased the expression of...
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NAMPT enzyme activity regulates catabolic gene expression in gingival fibroblasts during periodontitis

Park KH, Kim DK, Huh YH, Lee G, Lee SH, Hong Y, Kim SH, Kook MS, Koh JT, Chun JS, Lee SE, Ryu JH

Periodontal disease is one of the most prevalent chronic disorders worldwide. It is accompanied by inflammation of the gingiva and destruction of periodontal tissues, leading to alveolar bone loss. Here,...
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SH3BP4, a novel pigmentation gene, is inversely regulated by miR-125b and MITF

Kim KH, Lee TR, Cho EG

Our previous work has identified miR-125b as a negative regulator of melanogenesis. However, the specific melanogenesis-related genes targeted by this miRNA had not been identified. In this study, we established...
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The tyrosine kinase inhibitor nintedanib activates SHP-1 and induces apoptosis in triple-negative breast cancer cells

Liu CY, Huang TT, Chu PY, Huang CT, Lee CH, Wang WL, Lau KY, Tsai WC, Chao TI, Su JC, Chen MH, Shiau CW, Tseng LM, Chen KF

Triple-negative breast cancer (TNBC) remains difficult to treat and urgently needs new therapeutic options. Nintedanib, a multikinase inhibitor, has exhibited efficacy in early clinical trials for HER2-negative breast cancer. In...
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Nutlin-3 enhances the bortezomib sensitivity of p53-defective cancer cells by inducing paraptosis

Lee DM, Kim IY, Seo MJ, Kwon MR, Choi KS

The proteasome inhibitor, bortezomib, is ineffective against many solid tumors. Nutlin-3 is a potent antagonist of human homolog of murine double minute 2/p53 interaction exhibiting promising therapeutic anti-cancer activity. In...
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Sex-specific regulation of immune responses by PPARs

Park HJ, Choi JM

The prevalence of autoimmune, infectious and metabolic diseases is different for men and women owing to the respective ability of their immune systems to respond to self and foreign antigens....
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MicroRNA-143 and -145 modulate the phenotype of synovial fibroblasts in rheumatoid arthritis

Hong BK, You S, Yoo SA, Park D, Hwang D, Cho CS, Kim WU

Fibroblast-like synoviocytes (FLSs) constitute a major cell subset of rheumatoid arthritis (RA) synovia. Dysregulation of microRNAs (miRNAs) has been implicated in activation and proliferation of RA-FLSs. However, the functional association...
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dNP2-ctCTLA-4 inhibits German cockroach extract-induced allergic airway inflammation and hyper-responsiveness via inhibition of Th2 responses

Lim S, Sohn JH, Koo JH, Park JW, Choi JM

German cockroaches are major household allergens that can trigger allergic airway inflammatory diseases with sensitive T-cell responses. Although the use of immune modulatory biologics, such as antibodies, to mediate allergic...
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