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Chronic stress accelerates ligature-induced periodontitis by suppressing glucocorticoid receptor-α signaling

Lu H, Xu M, Wang F, Liu S, Gu J, Lin S, Zhao L

Periodontitis is a common chronic inflammatory disease. Recent studies have shown that chronic stress (CS) might modulate periodontal disease, but there are few models of CS-induced periodontitis, and the underlying...
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ANT2 shRNA downregulates miR-19a and miR-96 through the PI3K/Akt pathway and suppresses tumor growth in hepatocellular carcinoma cells

Baik SH, Lee J, Lee YS, Jang JY, Kim CW

MicroRNAs (miRNAs) are negative regulators of gene expression, and miRNA deregulation is found in various tumors. We previously reported that suppression of adenine nucleotide translocase 2 (ANT2) by short hairpin...
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Myeloid deletion of SIRT1 suppresses collagen-induced arthritis in mice by modulating dendritic cell maturation

Woo SJ, Lee SM, Lim HS, Hah YS, Jung ID, Park YM, Kim HO, Cheon YH, Jeon MG, Jang KY, Kim KM, Park BH, Lee SI

The type III histone deacetylase silent information regulator 1 (SIRT1) is an enzyme that is critical for the modulation of immune and inflammatory responses. However, the data on its role...
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Recent progress in genetic and epigenetic research on type 2 diabetes

Kwak SH, Park KS

Type 2 diabetes (T2DM) is a common complex metabolic disorder that has a strong genetic predisposition. During the past decade, progress in genetic association studies has enabled the identification of...
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Pancreatic regulation of glucose homeostasis

Röder PV, Wu B, Liu Y, Han W

In order to ensure normal body function, the human body is dependent on a tight control of its blood glucose levels. This is accomplished by a highly sophisticated network of...
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Regulation of glucose metabolism from a liver-centric perspective

Han HS, Kang G, Kim JS, Choi BH, Koo SH

Glucose homeostasis is tightly regulated to meet the energy requirements of the vital organs and maintain an individual's health. The liver has a major role in the control of glucose...
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Crosstalk between the heart and peripheral organs in heart failure

Jahng JW, Song E, Sweeney G

Mediators from peripheral tissues can influence the development and progression of heart failure (HF). For example, in obesity, an altered profile of adipokines secreted from adipose tissue increases the incidence...
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Emerging role of the brain in the homeostatic regulation of energy and glucose metabolism

Roh E, Song DK, Kim MS

Accumulated evidence from genetic animal models suggests that the brain, particularly the hypothalamus, has a key role in the homeostatic regulation of energy and glucose metabolism. The brain integrates multiple...
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Heterogeneity of white adipose tissue: molecular basis and clinical implications

Kwok KH, Lam KS, Xu A

Adipose tissue is a highly heterogeneous endocrine organ. The heterogeneity among different anatomical depots stems from their intrinsic differences in cellular and physiological properties, including developmental origin, adipogenic and proliferative...
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Dynamic cross talk between metabolic organs in obesity and metabolic diseases

Kim JB

No abstract available.
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Estrogen-related receptor γ is upregulated in liver cancer and its inhibition suppresses liver cancer cell proliferation via induction of p21 and p27

Kim JH, Choi YK, Byun JK, Kim MK, Kang YN, Kim SH, Lee S, Jang BK, Park KG

Orphan nuclear receptor estrogen-related receptor γ (ERRγ) regulates cell growth and tumorigenesis in various cancers. However, the clinical relevance of ERRγ to hepatocellular carcinoma (HCC) remains unclear. Here we examined...
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