- Somatic mutations in disorders with disrupted brain connectivity
-
Lee JH
- KMID: 2361526
- Exp Mol Med.
- 2016 Jun;48(6):e239.
- doi: 10.1038/emm.2016.53
Mutations occur during cell division in all somatic lineages. Because neurogenesis persists throughout human life, somatic mutations in the brain arise during development and accumulate with the aging process. The... -
- CITED
-
- Close
- SHARE
-
- Close
- RBP2 induces stem-like cancer cells by promoting EMT and is a prognostic marker for renal cell carcinoma
-
Zhou D, Kannappan , Chen X, Li J, Leng X, Zhang J, Xuan S
- KMID: 2361525
- Exp Mol Med.
- 2016 Jun;48(6):e238.
- doi: 10.1038/emm.2016.37
Renal cell carcinoma (RCC), one of the most common kidney cancers, has a poor prognosis. Epithelial to mesenchymal transition (EMT) is a hallmark of carcinoma invasion and metastasis. Several studies... -
- CITED
-
- Close
- SHARE
-
- Close
- SOCS1 suppresses IL-1β-induced C/EBPβ expression via transcriptional regulation in human chondrocytes
-
Ha YJ, Choi YS, Kang EH, Shin K, Kim TK, Song YW, Lee YJ
- KMID: 2361528
- Exp Mol Med.
- 2016 Jun;48(6):e241.
- doi: 10.1038/emm.2016.47
CAAT/enhancer-binding protein-beta (C/EBPβ) is a transcription factor that regulates interleukin-1β (IL-1β)-induced catabolic pathways, including the expression of matrix metalloproteinases (MMPs), in chondrocytes. We previously reported that suppressor of cytokine signaling... -
- CITED
-
- Close
- SHARE
-
- Close
- Regulation of retinal angiogenesis by phospholipase C-β3 signaling pathway
-
Ha JM, Baek SH, Kim YH, Jin SY, Lee HS, Kim SJ, Shin HK, Lee DH, Song SH, Kim CD, Bae SS
- KMID: 2361527
- Exp Mol Med.
- 2016 Jun;48(6):e240.
- doi: 10.1038/emm.2016.39
Angiogenesis has an essential role in many pathophysiologies. Here, we show that phospholipase C-β3 (PLC-β3) isoform regulates endothelial cell function and retinal angiogenesis. Silencing of PLC-β3 in human umbilical vein... -
- CITED
-
- Close
- SHARE
-
- Close
- Concurrent progress of reprogramming and gene correction to overcome therapeutic limitation of mutant ALK2-iPSC
-
Kim BY, Jeong S, Lee SY, Lee SM, Gweon EJ, Ahn H, Kim J, Chung SK
- KMID: 2361524
- Exp Mol Med.
- 2016 Jun;48(6):e237.
- doi: 10.1038/emm.2016.43
Fibrodysplasia ossificans progressiva (FOP) syndrome is caused by mutation of the gene ACVR1, encoding a constitutive active bone morphogenetic protein type I receptor (also called ALK2) to induce heterotopic ossification... -
- CITED
-
- Close
- SHARE
-
- Close
- S-adenosylmethionine reduces airway inflammation and fibrosis in a murine model of chronic severe asthma via suppression of oxidative stress
-
Yoon SY, Hong GH, Kwon HS, Park S, Park SY, Shin B, Kim TB, Moon HB, Cho YS
- KMID: 2361523
- Exp Mol Med.
- 2016 Jun;48(6):e236.
- doi: 10.1038/emm.2016.35
Increased oxidative stress has an important role in asthmatic airway inflammation and remodeling. A potent methyl donor, S-adenosylmethionine (SAMe), is known to protect against tissue injury and fibrosis through modulation... -
- CITED
-
- Close
- SHARE
-
- Close
