- Galectin-3 increases the motility of mouse melanoma cells by regulating matrix metalloproteinase-1 expression
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Wang YG, Kim SJ, Baek JH, Lee HW, Jeong SY, Chun KH
- KMID: 1383801
- Exp Mol Med.
- 2012 Jun;44(6):387-393.
Although mounting evidence indicates the involvement of galectin-3 in cancer progression and metastasis, the underlying molecular mechanisms remain largely unknown. In this study, we investigated the effect and possible mechanism... -
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- A priming role of local estrogen on exogenous estrogen-mediated synaptic plasticity and neuroprotection
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Chamniansawat S, Chongthammakun S
- KMID: 1383803
- Exp Mol Med.
- 2012 Jun;44(6):403-411.
The localization of estrogen (E2) has been clearly shown in hippocampus, called local hippocampal E2. It enhanced neuronal synaptic plasticity and protected neuron form cerebral ischemia, similar to those effects... -
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- A new synthetic chalcone derivative, 2-hydroxy-3',5,5'-trimethoxychalcone (DK-139), suppresses the Toll-like receptor 4-mediated inflammatory response through inhibition of the Akt/NF-kappaB pathway in BV2 microglial cells
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Lee YH, Jeon SH, Kim SH, Kim C, Lee SJ, Koh D, Lim Y, Ha K, Shin SY
- KMID: 1383799
- Exp Mol Med.
- 2012 Jun;44(6):369-377.
Microglial cells are the resident innate immune cells that sense pathogens and tissue injury in the central nervous system (CNS). Microglial activation is critical for neuroinflammatory responses. The synthetic compound... -
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- Dendroaspis natriuretic peptide regulates the cardiac L-type Ca2+ channel activity by the phosphorylation of alpha1c proteins
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Park SA, Kim TG, Han MK, Ha KC, Kim SZ, Kwak YG
- KMID: 1383798
- Exp Mol Med.
- 2012 Jun;44(6):363-368.
Dendroaspis natriuretic peptide (DNP), a new member of the natriuretic peptide family, is structurally similar to atrial, brain, and C-type natriuretic peptides. However, the effects of DNP on the cardiac... -
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- Association of ADIPOR1 polymorphisms with bone mineral density in postmenopausal Korean women
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Kim HY, Hwang JY, Han BG, Lee JY, Park EK, Kim BJ, Lee SH, Kim GS, Kim SY, Koh JM
- KMID: 1383802
- Exp Mol Med.
- 2012 Jun;44(6):394-402.
Adiponectin may affect bone through interactions with two known receptors, adiponectin receptors (ADIPOR) 1 and 2. We examined the association between polymorphisms of ADIPOR1 and ADIPOR2 and bone mineral density... -
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- 12(S)-Hydroxyheptadeca-5Z,8E,10E-trienoic acid suppresses UV-induced IL-6 synthesis in keratinocytes, exerting an anti-inflammatory activity
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Lee JW, Ryu HC, Ng YC, Kim C, Wei JD, Sabaratnam V, Kim JH
- KMID: 1383800
- Exp Mol Med.
- 2012 Jun;44(6):378-386.
12(S)-Hydroxyheptadeca-5Z,8E,10E-trienoic acid (12-HHT) is an enzymatic product of prostaglandin H2 (PGH2) derived from cyclooxygenase (COX)-mediated arachidonic acid metabolism. Despite the high level of 12-HHT present in tissues and bodily fluids,... -
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