- One target, different effects: a comparison of distinct therapeutic antibodies against the same targets
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Shim H
- KMID: 1123366
- Exp Mol Med.
- 2011 Oct;43(10):539-549.
- doi: 10.3858/emm.2011.43.10.063
To date, more than 30 antibodies have been approved worldwide for therapeutic use. While the monoclonal antibody market is rapidly growing, the clinical use of therapeutic antibodies is mostly limited... -
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- Comparative study of codon substitution patterns in foot-and-mouth disease virus (serotype O)
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Ahn I, Bae SE, Son HS
- KMID: 1123371
- Exp Mol Med.
- 2011 Oct;43(10):587-595.
- doi: 10.3858/emm.2011.43.10.066
We compared genetic variations in the VP1 gene of foot-and-mouth disease viruses (FMDVs) isolated since 2000 from various region of the world. We analyzed relative synonymous codon usage (RSCU) and... -
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- In vitro migration capacity of human adipose tissue-derived mesenchymal stem cells reflects their expression of receptors for chemokines and growth factors
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Baek SJ, Kang SK, Ra JC
- KMID: 1123372
- Exp Mol Med.
- 2011 Oct;43(10):596-603.
- doi: 10.3858/emm.2011.43.10.069
The homing properties of adipose tissue-derived mesenchymal stem cells (AdMSCs) have stimulated intravenous applications for their use in stem cell therapy. However, the soluble factors and corresponding cellular receptors responsible... -
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- Preclinical studies for pharmacokinetics and biodistribution of Ad-stTRAIL, an adenovirus delivering secretable trimeric TRAIL for gene therapy
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Kim CY, Park SH, Jeong M, Kwon OS, Doh H, Kang SH, Robbins PD, Kim BM, Seol DW, Kim BG
- KMID: 1123370
- Exp Mol Med.
- 2011 Oct;43(10):580-586.
- doi: 10.3858/emm.2011.43.10.065
Malignant glioma is the most frequent type in brain tumors. The prognosis of this tumor has not been significantly improved for the past decades and the average survival of patients... -
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- Insulin-dependent suppression of cholesterol 7alpha-hydroxlase is a possible link between glucose and cholesterol metabolisms
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Park WH, Pak YK
- KMID: 1123369
- Exp Mol Med.
- 2011 Oct;43(10):571-579.
- doi: 10.3858/emm.2011.43.10.064
Cholesterol 7alpha-hydroxylase (CYP7A1) regulates the balance between cholesterol supply and metabolism by catalyzing the rate-limiting step of bile acid biosynthesis. The transcriptional activity of CYP7A1 is tightly controlled by various... -
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- Methylation of eukaryotic elongation factor 2 induced by basic fibroblast growth factor via mitogen-activated protein kinase
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Jung GA, Shin BS, Jang YS, Sohn JB, Woo SR, Kim JE, Choi G, Lee KM, Min BH, Lee KH, Park GH
- KMID: 1123367
- Exp Mol Med.
- 2011 Oct;43(10):550-560.
- doi: 10.3858/emm.2011.43.10.061
Protein arginine methylation is important for a variety of cellular processes including transcriptional regulation, mRNA splicing, DNA repair, nuclear/cytoplasmic shuttling and various signal transduction pathways. However, the role of arginine... -
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- Grape seed proanthocyanidin extract ameliorates monosodium iodoacetate-induced osteoarthritis
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Woo YJ, Joo YB, Jung YO, Ju JH, Cho ML, Oh HJ, Jhun JY, Park MK, Park JS, Kang CM, Sung MS, Park SH, Kim HY, Min JK
- KMID: 1123368
- Exp Mol Med.
- 2011 Oct;43(10):561-570.
- doi: 10.3858/emm.2011.43.10.062
Osteoarthritis (OA) is an age-related joint disease that is characterized by degeneration of articular cartilage and chronic pain. Oxidative stress is considered one of the pathophysiological factors in the progression... -
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