- Rottlerin enhances IL-1beta-induced COX-2 expression through sustained p38 MAPK activation in MDA-MB-231 human breast cancer cells
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Park EJ, Kwon TK
- KMID: 1058704
- Exp Mol Med.
- 2011 Dec;43(12):669-675.
- doi: 10.3858/emm.2011.43.12.077
Cyclooxygenase-2 (COX-2) is an important enzyme in inflammation. In this study, we investigated the underlying molecular mechanism of the synergistic effect of rottlerin on interleukin1beta (IL-1beta)-induced COX-2 expression in MDA-MB-231... -
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- Effects of ferulic acid on diabetic nephropathy in a rat model of type 2 diabetes
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Choi R, Kim BH, Naowaboot , Lee MY, Hyun MR, Cho EJ, Lee ES, Lee EY, Yang YC, Chung CH
- KMID: 1058705
- Exp Mol Med.
- 2011 Dec;43(12):676-683.
- doi: 10.3858/emm.2011.43.12.078
Diabetic nephropathy is the most serious complication in diabetes mellitus. It is known that oxidative stress and inflammation play a central role in the development of diabetic nephropathy. In this... -
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- Caveolin-1 is involved in reactive oxygen species-induced SHP-2 activation in astrocytes
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Yun JH, Park SJ, Jo A, Kang JL, Jou I, Park JS, Choi YH
- KMID: 1058703
- Exp Mol Med.
- 2011 Dec;43(12):660-668.
- doi: 10.3858/emm.2011.43.12.075
Recent evidence supports a neuroprotective role of Src homology 2-containing protein tyrosine phosphatase 2 (SHP-2) against ischemic brain injury. However, the molecular mechanisms of SHP-2 activation and those governing how... -
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- Hypoxia induces Wee1 expression and attenuates hydrogen peroxide-induced endothelial damage in MS1 cells
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Hong KS, Kim HS, Kim SH, Lim DJ, Park JY, Kim SD
- KMID: 1058702
- Exp Mol Med.
- 2011 Dec;43(12):653-659.
- doi: 10.3858/emm.2011.43.12.074
In an oxygen-depleted environment, endothelial cells initiate an adaptive pattern of synthesis, which may enable them to survive hypoxic crises. Using high-resolution two-dimensional gel electrophoresis in conjunction with mass spectroscopy,... -
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- Inhibition of NF-kappaB prevents high glucose-induced proliferation and plasminogen activator inhibitor-1 expression in vascular smooth muscle cells
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Jeong IK, Oh DH, Park SJ, Kang JH, Kim S, Lee MS, Kim MJ, Hwang YC, Ahn KJ, Chung HY, Chae MK, Yoo HJ
- KMID: 1058706
- Exp Mol Med.
- 2011 Dec;43(12):684-692.
- doi: 10.3858/emm.2011.43.12.079
Recent epidemiologic studies clearly showed that early intensive glucose control has a legacy effect for preventing diabetic macrovascular complications. However, the cellular and molecular processes by which high glucose leads... -
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- Relationship between ganglioside expression and anti-cancer effects of the monoclonal antibody against epithelial cell adhesion molecule in colon cancer
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Kwak DH, Ryu JS, Kim CH, Ko K, Ma JY, Hwang KA, Choo YK
- KMID: 1058707
- Exp Mol Med.
- 2011 Dec;43(12):693-701.
- doi: 10.3858/emm.2011.43.12.080
The human colorectal carcinoma-associated GA733 antigen epithelial cell adhesion molecule (EpCAM) was initially described as a cell surface protein selectively expressed in some myeloid cancers. Gangliosides are sialic acid-containing glycosphingolipids... -
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