- Further understanding of fat biology: Lessons from a fat fly
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Hong JW, Park KW
- KMID: 946665
- Exp Mol Med.
- 2010 Jan;42(1):12-20.
- doi: 10.3858/emm.2010.42.1.007
Obesity is a leading risk factor for insulin resistance, hypertension, hyperlipidemia, and cardiovascular complications, collectively referred to as metabolic diseases. Given the prevalence of obesity and its associated medical problems,... -
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- Parathyroid hormone accelerates decompensation following left ventricular hypertrophy
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Cha H, Jeong HJ, Jang SP, Kim JY, Yang DK, Oh JG, Park WJ
- KMID: 946670
- Exp Mol Med.
- 2010 Jan;42(1):61-68.
- doi: 10.3858/emm.2010.42.1.006
Parathyroid hormone (PTH) treatment was previously shown to improve cardiac function after myocardial infarction by enhancing neovascularization and cell survival. In this study, pressure overload-induced left ventricular hypertrophy (LVH) was... -
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- Mass spectrometry based cellular phosphoinositides profiling and phospholipid analysis: A brief review
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Kim Y, Shanta SR, Zhou LH, Kim KP
- KMID: 946664
- Exp Mol Med.
- 2010 Jan;42(1):1-11.
- doi: 10.3858/emm.2010.42.1.001
Phospholipids are key components of cellular membrane and signaling. Among cellular phospholipids, phosphoinositides, phosphorylated derivatives of phosphatidylinositol are important as a participant in essential metabolic processes in animals. However, due... -
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- Cyclic AMP prolongs graft survival by suppressing apoptosis and inflammatory gene expression in acute cardiac allograft rejection
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Lee JY, Kim JH, Chae G, Lee BK, Ha KS, Kwon YG, Kim YM
- KMID: 946671
- Exp Mol Med.
- 2010 Jan;42(1):69-79.
- doi: 10.3858/emm.2010.42.1.008
This study was designed to investigate the effects of cAMP on immune regulation and apoptosis during acute rat cardiac allograft rejection. We found that the production of immune markers such... -
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- Neuronal RNA granule contains ApCPEB1, a novel cytoplasmic polyadenylation element binding protein, in Aplysia sensory neuron
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Chae YS, Lee SH, Cheang YH, Lee N, Rim YS, Jang DJ, Kaang BK
- KMID: 946667
- Exp Mol Med.
- 2010 Jan;42(1):30-37.
- doi: 10.3858/emm.2010.42.1.003
The cytoplasmic polyadenylation element (CPE)-binding protein (CPEB) binds to CPE containing mRNAs on their 3' untranslated regions (3'UTRs). This RNA binding protein comes out many important tasks, especially in learning... -
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- Aspirin attenuates the anti-inflammatory effects of theophylline via inhibition of cAMP production in mice with non-eosinophilic asthma
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Moon HG, Kim YS, Choi JP, Choi DS, Yoon CM, Jeon SG, Gho YS, Kim YK
- KMID: 946669
- Exp Mol Med.
- 2010 Jan;42(1):47-60.
- doi: 10.3858/emm.2010.42.1.005
Theophylline is commonly used to treat severe asthma and chronic obstructive pulmonary disease (COPD) characterized by non-eosinophilic inflammation. Acetyl salicylic acid (ASA) is one of the most widely used medications... -
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- Induction of tissue inhibitor of matrix metalloproteinase-2 by cholesterol depletion leads to the conversion of proMMP-2 into active MMP-2 in human dermal fibroblasts
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Kim S, Oh JH, Lee Y, Lee J, Cho KH, Chung JH
- KMID: 946668
- Exp Mol Med.
- 2010 Jan;42(1):38-46.
- doi: 10.3858/emm.2010.42.1.004
Cholesterol is one of major components of cell membrane and plays a role in vesicular trafficking and cellular signaling. We investigated the effects of cholesterol on matrix metalloproteinase-2 (MMP-2) activation... -
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- Orphan nuclear receptor small heterodimer partner inhibits angiotensin II-stimulated PAI-1 expression in vascular smooth muscle cells
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Lee KM, Seo HY, Kim MK, Min AK, Ryu SY, Kim YN, Park YJ, Choi HS, Lee KU, Park WJ, Park KG, Lee IK
- KMID: 946666
- Exp Mol Med.
- 2010 Jan;42(1):21-29.
- doi: 10.3858/emm.2010.42.1.002
Angiotensin II is a major effector molecule in the development of cardiovascular disease. In vascular smooth muscle cells (VSMCs), angiotensin II promotes cellular proliferation and extracellular matrix accumulation through the... -
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